Yasuko Isoe

A Visual Interface for Exploring Hypotheses About Neural Circuits

IEEE Transactions on Visualization and Computer Graphics · 2023-02-09 · 8 citations

One of the fundamental problems in neurobiological research is to understand how neural circuits generate behaviors in response to sensory stimuli. Elucidating such neural circuits requires anatomical and functional information about the neurons that are active during the processing of the sensory information and generation of the respective response, as well as an identification of the connections between these neurons. With modern imaging techniques, both morphological properties of individual…

Epigenetically distinct synaptic architecture in clonal compartments in the teleostean dorsal pallium

eLife · 2023-06-29 · 4 citations

The dorsal telencephalon (i.e. the pallium) exhibits high anatomical diversity across vertebrate classes. The non-mammalian dorsal pallium accommodates various compartmentalized structures among species. The developmental, functional, and evolutional diversity of the dorsal pallium remain unillustrated. Here, we analyzed the structure and epigenetic landscapes of cell lineages in the telencephalon of medaka fish ( Oryzias latipes ) that possesses a clearly delineated dorsal pallium (Dd2). We fou…

Multi-species community platform for comparative neuroscience in teleost fish

bioRxiv (Cold Spring Harbor Laboratory) · 2024-02-15 · 3 citations

Abstract Studying neural mechanisms in complementary model organisms from different ecological niches in the same animal class can leverage the comparative brain analysis at the cellular level. To advance such a direction, we developed a unified brain atlas platform and specialized tools that allowed us to quantitatively compare neural structures in two teleost larvae, medaka ( Oryzias latipes ) and zebrafish ( Danio rerio ). Leveraging this quantitative approach we found that most brain regions…

Quantifying Social Interactions in Medaka Fish

Neuromethods · 2022-01-01 · 3 citations

Fishexplorer: A multimodal cellular atlas platform for neuronal circuit dissection in larval zebrafish

bioRxiv (Cold Spring Harbor Laboratory) · 2025-07-15 · 1 citations

Understanding how neural circuits give rise to behavior requires comprehensive knowledge of neuronal morphology, connectivity, and function. Atlas platforms play a critical role in enabling the visualization, exploration, and dissemination of such information. Here, we present FishExplorer, an interactive and expandable community platform designed to integrate and analyze multimodal brain data from larval zebrafish. FishExplorer supports datasets acquired through light microscopy (LM), electron…