About

Xin Wang is an Associate Professor in the Department of Microbiology and Cell Science at the University of Florida. His research focuses on the designing principles of cells and their applications in synthetic biology. He employs experimental evolution, genetics, and biochemistry approaches to identify and characterize genetic traits that are associated with increased photosynthetic efficiency in cyanobacteria. This work aims to enhance understanding of cellular design and improve photosynthetic processes through synthetic biology techniques.

Research topics

• Data Mining
• Artificial Intelligence
• Computer Science
• Psychology

Selected publications

• Engineering of isoleucine dioxygenase for efficient multi-enzymatic cascade synthesis of (2S, 3R, 4S)-4-hydroxyisoleucine

  Bioorganic Chemistry · 2025-11-05

  article
  PublisherDOI

• Minimum adjustment consensus model for multi-person multi-criteria large scale decision-making with trust consistency propagation and opinion dynamics

  Information Fusion · 2024 · 4 citations

  1st authorCorresponding
  • Computer Science
  • Computer Science
  • Artificial Intelligence
  PublisherDOI

• Nitroalkanes as Thioacyl Equivalents to Access Thioamides and Thiopeptides

  Figshare · 2023-01-01

  datasetOpen access1st authorCorresponding

  The direct coupling of readily available nitroalkane and amines with just S8 and Na2S, provides an efficient way to make thioamides and thiopeptides. Mechanistic insights indicated acyl nitrite was the key intermediates. With this in-situ generated thioacylating reagents, a wide of thioamide-containing bioactive compounds were easily prepared.

  PublisherDOI

• Immune responses to human factor IX in haemophilia B mice of different genetic backgrounds are distinct and modified by TLR4

  Haemophilia · 2014-11-23 · 10 citations

  articleOpen access

  Our laboratory develops protocols to prevent or reverse ongoing anti-hFIX IgG inhibitors in haemophilia B mice with a F9 gene deletion on BALB/c and C3H/HeJ backgrounds. C3H/HeJ F9(-/Y) mice develop high titre anti-hFIX IgG1 inhibitors and anaphylaxis, whereas most BALB/c F9(-/Y) mice have mild anti-hFIX IgG1 inhibitors and no anaphylaxis. Our aim was to determine if hFIX-specific B- and T-cell responses in BALB/c and C3H/HeJ F9(-/Y) mice trigger the difference in anti-hFIX immune responses. BALB/c and C3H/HeJ F9(-/Y) mice were challenged weekly with recombinant hFIX protein. Humoral immune responses were determined by IgG1 and IgG2a anti-hFIX ELISA, Bethesda assay for inhibitors and B-cell ELISpot on bone marrow and spleen cells. T-cell studies measured the TH 1 (IFN-γ) and TH 2 (IL-4) cytokine responses in splenocytes at the mRNA and protein level in response to hFIX protein. Antibody responses were also measured in C3H/HeJ/OuJ F9(-/Y) mice with restored toll-like receptor 4 (TLR4) function. BALB/c F9(-/Y) mice have a TH 2 skewed response and a reduction in anti-hFIX secreting plasma cells in the bone marrow. Independent antigen challenge revealed both strains generated equivalent IgG1 antibody titres to an intravenously delivered antigen. C3H/HeJ F9(-/Y) mice have a mixed TH 1 and TH 2 response (mainly TH 2). Importantly, TLR4 signalling has a modulatory role in the C3H background on the levels of anti-hFIX IgG1 and incidence of anaphylaxis. The background strain strongly impacts the immune response to hFIX, which can be significantly impacted by mutations in innate immune sensors.

  PublisherOA PDFDOI

• Gut microbiota correlates with energy gain from dietary fibre and appears to be associated with acute and chronic intestinal diseases

  Clinical Microbiology and Infection · 2012-05-31 · 20 citations

  reviewOpen access
  PublisherOA PDFDOI

• A large-scale benchmark study of existing algorithms for taxonomy-independent microbial community analysis

  Briefings in Bioinformatics · 2011-04-27 · 167 citations

  articleOpen access

  Recent advances in massively parallel sequencing technology have created new opportunities to probe the hidden world of microbes. Taxonomy-independent clustering of the 16S rRNA gene is usually the first step in analyzing microbial communities. Dozens of algorithms have been developed in the last decade, but a comprehensive benchmark study is lacking. Here, we survey algorithms currently used by microbiologists, and compare seven representative methods in a large-scale benchmark study that addresses several issues of concern. A new experimental protocol was developed that allows different algorithms to be compared using the same platform, and several criteria were introduced to facilitate a quantitative evaluation of the clustering performance of each algorithm. We found that existing methods vary widely in their outputs, and that inappropriate use of distance levels for taxonomic assignments likely resulted in substantial overestimates of biodiversity in many studies. The benchmark study identified our recently developed ESPRIT-Tree, a fast implementation of the average linkage-based hierarchical clustering algorithm, as one of the best algorithms available in terms of computational efficiency and clustering accuracy.

  PublisherOA PDFDOI

• Cooperative recombination of electron-hole pairs in semiconductor quantum wells under quantizing magnetic fields

  Physical Review B · 2010-04-19 · 29 citations

  articleOpen access

  We present results of detailed investigations of light emission from semiconductor multiple quantum wells at low temperatures and high magnetic fields excited by intense femtosecond laser pulses. The intensity and linewidth as well as the directional and statistical properties of photoemission strongly depended on the magnetic field strength and pump laser fluence. We also investigated the effects of spot size, temperature, excitation geometry, and excitation pulse width on the emission properties. The results suggest that the initially incoherent photoexcited electron-hole pairs spontaneously form a macroscopic coherent state upon relaxation into the low-lying magnetoexcitonic states, followed by the emission of a superfluorescent burst of radiation. We have developed a theoretical model for superfluorescent emission from semiconductor quantum wells, which successfully explained the observed characteristics.

  PublisherOA PDFDOI

• Superfluorescence from high-density magneto-plasmas: Mixing, temperature, and excitation pulsewidth dependence

  2007-05-01

  article

  Ultrafast cooperative recombination from dense electron-hole plasmas in quantum wells is reported as a function of energy level mixing, temperature, and excitation pulse width under strong magnetic fields (up to 31 T).

  PublisherDOI

• Evidence for Superfluorescent Recombination from Dense Magneto-plasmas

  Springer series in chemical physics · 2007-01-01

  book-chapter1st authorCorresponding
  PublisherDOI

• Superfluorescence from magnetically formed quantum dots: mixing, temperature, and excitation pulsewidth dependence

  2007-08-01

  article

  Ultrafast cooperative recombination from dense electron-hole plasmas in magnetically formed quantum dots (with magnetic field up to 31 T) was investigated as a function of energy level mixing, temperature, and excitation pulse width.

  PublisherDOI

Frequent coauthors

• Junichiro Kono

  Rice University

  11 shared

• Young-Dahl Jho

  Gwangju Institute of Science and Technology

  11 shared

• Volker Mai

  University of Florida

  10 shared

• Yunpeng Cai

  9 shared

• X. Wei

  9 shared

• D. H. Reitze

  California Institute of Technology

  9 shared

• William G. Farmerie

  University of Florida

  9 shared

• Rob Knight

  University of California, San Diego

  9 shared

Labs

• Wang LabPI

Education

• Ph.D., Microbiology and Cell Science

  University of Florida

• M.S., Microbiology and Cell Science

  University of Florida

• B.S., Microbiology and Cell Science

  University of Florida