Xin Tu
· PhD, ProfessorUniversity of California, San Diego · Climate and Environmental Sciences
Active 1989–2026
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About
Xin Tu is a professor at the Herbert Wertheim School of Public Health & Human Longevity Science at UCSD. His research focuses on various aspects of public health, including longitudinal T-cell phenotypic dynamics during sustained antiretroviral therapy in people with HIV, associations between environmental exposures such as insecticide metabolites and neurocognitive performance, and the role of inflammation biomarkers in neurobehavioral performance among adolescents. His work also explores the relationships between loneliness, cognitive function, and mental health in populations with schizophrenia and other psychiatric conditions. Additionally, Tu investigates the impact of environmental health factors, including PFAS and pesticides, on lung function and metabolic health from adolescence to young adulthood. His contributions extend to understanding the biological mechanisms underlying cardiovascular and neurological diseases, as well as the social and behavioral determinants of health, with a particular emphasis on vulnerable populations.
Research topics
- Medicine
- Internal medicine
- Gastroenterology
- Psychology
- Biology
- Gerontology
- Genetics
- Psychiatry
- Bioinformatics
- Radiology
Selected publications
Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease
Gastroenterology · 2020 · 204 citations
Intestinal Virome in Patients With Alcoholic Hepatitis
Hepatology · 2020 · 141 citations
BACKGROUND AND AIMS: Alcoholic hepatitis (AH) is a severe manifestation of alcohol-associated liver disease (ALD) with high mortality. Although gut bacteria and fungi modulate disease severity, little is known about the effects of the viral microbiome (virome) in patients with ALD. APPROACH AND RESULTS: We extracted virus-like particles from 89 patients with AH who were enrolled in a multicenter observational study, 36 with alcohol use disorder (AUD), and 17 persons without AUD (controls). Virus…
Gastroenterology · 2022 · 125 citations
Alzheimer s & Dementia · 2021 · 81 citations
INTRODUCTION: The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression. METHODS: , cognition, amnestic mild cognitive impairment (aMCI), and daytime dysfunction. RESULTS: was associated with poorer episodic memory, general verbal fluency, semantic fluency, and processing speed, as well as increased odds of aMCI and greater daytime dysfunction. DISCUS…
Associations between depression and cardiometabolic health: A 27-year longitudinal study
Psychological Medicine · 2021 · 42 citations
BACKGROUND: Clarifying the relationship between depression symptoms and cardiometabolic and related health could clarify risk factors and treatment targets. The objective of this study was to assess whether depression symptoms in midlife are associated with the subsequent onset of cardiometabolic health problems. METHODS: The study sample comprised 787 male twin veterans with polygenic risk score data who participated in the Harvard Twin Study of Substance Abuse ('baseline') and the longitudinal…
Recent grants
NIH · $453k · 2000
Frequent coauthors
- 140 shared
Bonnie Bruce
Emory University
- 131 shared
Ellen Lee
Institute on Aging
- 129 shared
Hua He
Tibet Autonomous Region People's Hospital
- 129 shared
Julie Falardeau
- 129 shared
Anil D. Patel
Rajiv Gandhi Cancer Institute and Research Centre
- 129 shared
Byron L. Lam
Miami Dermatology and Laser Institute
- 129 shared
Robert Granadier
Beaumont Health
- 129 shared
Reid Longmuir
Vanderbilt University Medical Center
Education
- 2005
Ph.D., Public Health
University of California, San Diego
- 2001
M.S., Environmental Health Sciences
University of California, San Diego
- 1999
B.S., Environmental Health Sciences
University of California, San Diego
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