Xin Li
· Professor in the Department of Electrical and Computer EngineeringDuke University · Electrical and Computer Engineering
Active 2003–2025
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About
Xin Li is a Professor in the Department of Electrical and Computer Engineering at Duke University. He received his Ph.D. in Electrical and Computer Engineering from Carnegie Mellon University in 2005, and his M.S. and B.S. degrees in Electronics Engineering from Fudan University in Shanghai, China, in 2001 and 1998, respectively. His research interests include integrated circuits, signal processing, and data analytics. He has held significant roles such as co-founding Xigmix Inc. to commercialize his Ph.D. research, serving as its Chief Technical Officer until its acquisition by Extreme DA, which was further acquired by Synopsis. He has also contributed to national research initiatives, including serving as Assistant Director for the FCRP Focus Research Center for Circuit & System Solutions (C2S2) and the Center for Silicon System Implementation (CSSI) at Carnegie Mellon University. Xin Li has been recognized with numerous awards, including the NSF CAREER Award and multiple Best Paper Awards from prestigious conferences. He has also served as an associate editor for several IEEE and ACM journals and has been involved in various professional committees and leadership roles within the research community.
Research topics
- Medicine
- Chemistry
- Pharmacology
- Biophysics
- Biochemistry
- Internal medicine
- Materials science
- Nanotechnology
- Biology
- Immunology
Selected publications
Nature Biomedical Engineering · 2017-06-05 · 125 citations
articleOpen accessBiomaterials · 2018-11-27 · 92 citations
articleOpen accessAdvanced Science · 2022 · 66 citations
Protein therapeutics, except for antibodies, have a short plasma half-life and poor stability in circulation. Covalent coupling of polyethylene glycol (PEG) to protein drugs addresses this limitation. However, unlike previously thought, PEG is immunogenic. In addition to induced PEG antibodies, ≈70% of the US population has pre-existing anti-PEG antibodies. Both induced and preexisting anti-PEG antibodies result in accelerated drug clearance, reduced clinical efficacy, and severe hypersensitivit…
Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity
Journal of Controlled Release · 2017-11-13 · 63 citations
articleConjugate of Doxorubicin to Albumin‐Binding Peptide Outperforms Aldoxorubicin
Small · 2019-02-13 · 60 citations
articleOpen accessShort circulation time and off-target toxicity are the main challenges faced by small-molecule chemotherapeutics. To overcome these shortcomings, an albumin-binding peptide conjugate of chemotherapeutics is developed that binds specifically to endogenous albumin and harnesses its favorable pharmacokinetics and pharmacodynamics for drug delivery to tumors. A protein-G-derived albumin-binding domain (ABD) is conjugated with doxorubicin (Dox) via a pH-sensitive linker. One to two Dox molecules are…
Frequent coauthors
- 60 shared
Ashutosh Chilkoti
Duke University
- 24 shared
Jeffrey L. Schaal
Pratt Institute
- 20 shared
Ivan Spasojević
- 19 shared
Jayanta Bhattacharyya
- 19 shared
Wenge Liu
Baidu (China)
- 17 shared
Samagya Banskota
Duke University
- 15 shared
Soumen Saha
Duke University
- 15 shared
Nikita Zakharov
Pratt Institute
Awards & honors
- Fellow. Institute of Electrical and Electronics Engineers (2…
- IEEE Donald O. Pederson Best Paper Award (2016)
- IEEE Donald O. Pederson Best Paper Award (2013)
- Best Paper Award from Design Automation Conference (2010)
- IEEE/ACM William J. McCalla ICCAD Best Paper Award (2011)
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