Xiaoping Bao

About

The Bao research group applies chemical and cellular engineering approaches to differentiate and biomanufacturing human stem cell therapeutics targeting various diseases such as cardiovascular diseases and cancer. Our group is part of the Davidson School of Chemical Engineering.

Research topics

• Biology
• Immunology
• Materials science
• Chemistry
• Medicine
• Optoelectronics
• Pathology
• Cancer research
• Computer Science
• Genetics

Selected publications

• CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy

  Nature Communications · 2023 · 192 citations

  Senior authorCorresponding

  Glioblastoma (GBM) is one of the most aggressive and lethal solid tumors in human. While efficacious therapeutics, such as emerging chimeric antigen receptor (CAR)-T cells and chemotherapeutics, have been developed to treat various cancers, their effectiveness in GBM treatment has been hindered largely by the blood-brain barrier and blood-brain-tumor barriers. Human neutrophils effectively cross physiological barriers and display effector immunity against pathogens but the short lifespan and res…

  DOI

• Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy

  Cell Reports · 2022 · 99 citations

  Senior authorCorresponding

  Neutrophils, the most abundant white blood cells in circulation, are closely related to cancer development and progression. Healthy primary neutrophils present potent cytotoxicity against various cancer cell lines through direct contact and via generation of reactive oxygen species. However, due to their short half-life and resistance to genetic modification, neutrophils have not yet been engineered with chimeric antigen receptors (CARs) to enhance their antitumor cytotoxicity for targeted immun…

  DOI

• Ultrasensitive and Selective Detection of SARS-CoV-2 Using Thermotropic Liquid Crystals and Image-Based Machine Learning

  Cell Reports Physical Science · 2020 · 77 citations

  Rapid, robust virus-detection techniques with ultrahigh sensitivity and selectivity are required for the outbreak of the pandemic coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Here, we report that the femtomolar concentrations of single-stranded ribonucleic acid (ssRNA) of SARS-CoV-2 trigger ordering transitions in liquid crystal (LC) films decorated with cationic surfactant and complementary 15-mer single-stranded deoxyribonuclei…

  PublisherDOI

• Stimuli‐Responsive Liquid‐Crystal‐Infused Porous Surfaces for Manipulation of Underwater Gas Bubble Transport and Adhesion

  Advanced Materials · 2022 · 41 citations

  Biomimetic artificial surfaces that enable the manipulation of gas bubble mobility have been explored in a wide range of applications in nanomaterial synthesis, surface defouling, biomedical diagnostics, and therapeutics. Although many superhydrophobic surfaces and isotropic-lubricant-infused porous surfaces have been developed to manipulate gas bubbles, the simultaneous control over the adhesion and transport of gas bubbles underwater remains a challenge. Thermotropic liquid crystals (LCs), a c…

  PublisherOA PDFDOI

• Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment

  Bioactive Materials · 2024-09-10 · 24 citations

  reviewOpen access

  Adoptive immunotherapy, notably involving chimeric antigen receptor (CAR)-T cells, has obtained Food and Drug Administration (FDA) approval as a treatment for various hematological malignancies, demonstrating promising preclinical efficacy against cancers. However, the intricate and resource-intensive autologous cell processing, encompassing collection, expansion, engineering, isolation, and administration, hamper the efficacy of this therapeutic modality. Furthermore, conventional CAR T therapy…

  PublisherDOI

Recent grants

• Engineer Biomimetic Microfluidic Models to Investigate and Reprogram Tumor Associated Neutrophils for Cancer Therapy

  NIH · $1.4M · 2022–2027

• CAREER: Engineering ex vivo Human Cardiogenesis with Optogenetics

  NSF · $547k · 2022–2027

Frequent coauthors

• Yun Chang

  Purdue University West Lafayette

  65 shared

• Xiaojun Lian

  Pennsylvania State University

  46 shared

• Gyuhyung Jin

  Purdue University West Lafayette

  40 shared

• Sean P. Palecek

  University of Wisconsin–Madison

  35 shared

• Qing Deng

  Purdue University West Lafayette

  27 shared

• Vijesh J. Bhute

  Imperial College London

  25 shared

• Bennett D. Elzey

  Purdue University West Lafayette

  20 shared

• Sandra Torregrosa‐Allen

  Purdue University Institute for Cancer Research

  20 shared

Labs

• The Bao LaboratoryPI

Education

• Ph.D., Chemical and Biological Engineering

  University of Wisconsin Madison

  2016

• BS, Chemical and Biological Engineering

  Tsinghua University

  2011

Awards & honors

• Purdue College of Engineering (COE) Faculty Excellence Award…
• Purdue Institute for Cancer Research Early Career Research A…
• BMES-CMBE Rising Star Junior Faculty Award (2023)
• NSF CAREER Award (2022)
• Showalter Research Trust Young Investigator Award (2020)

Similar researchers at Purdue University

• Rakesh Agrawalh-67
• Stephen Beaudoinh-32
• David Bernal Neirah-2