Xianghua Luo

About

Professor Xianghua Luo is a member of the Division of Biostatistics and Health Data Science, School of Public Health, and the Biostatistics Core at the Masonic Cancer Center, University of Minnesota. His research interests include development and application of statistical methods in various fields.

Research topics

• Medicine
• Computer Science
• Chemistry
• Internal medicine
• Biology
• Environmental health
• Surgery
• Metallurgy
• Nursing
• Cell biology

Selected publications

• Randomized Double-Blind Phase II Trial of Fecal Microbiota Transplantation Versus Placebo in Allogeneic Hematopoietic Cell Transplantation and AML

  Journal of Clinical Oncology · 2023 · 62 citations

  PURPOSE: Gut microbiota injury in allogeneic hematopoietic cell transplantation (HCT) recipients and patients with AML has been associated with adverse clinical outcomes. Previous studies in these patients have shown improvements in various microbiome indices after fecal microbiota transplantation (FMT). However, whether microbiome improvements translate into improved clinical outcomes remains unclear. We examined this question in a randomized, double-blind, placebo-controlled phase II trial. ME…

  DOI

• Metabolic programs drive function of therapeutic NK cells in hypoxic tumor environments

  Science Advances · 2024-10-30 · 40 citations

  articleOpen access

  Limited oxygen (hypoxia) in solid tumors poses a challenge to successful immunotherapy with natural killer (NK) cells. NK cells have impaired cytotoxicity when cultured in hypoxia (1% oxygen) but not physiologic (>5%) or atmospheric oxygen (20%). We found that changes to cytotoxicity were regulated at the transcriptional level and accompanied by metabolic dysregulation. Dosing with interleukin-15 (IL-15) enhanced NK cell cytotoxicity in hypoxia, but preactivation with feeder cells bearing IL-21…

  PublisherDOI

• Urinary Cyanoethyl Mercapturic Acid, a Biomarker of the Smoke Toxicant Acrylonitrile, Clearly Distinguishes Smokers From Nonsmokers

  Nicotine & Tobacco Research · 2020 · 22 citations

  1st authorCorresponding

  INTRODUCTION: Cyanoethyl mercapturic acid (CEMA) is a urinary metabolite of acrylonitrile, a toxicant found in substantial quantities in cigarette smoke, but not in non-combusted products such as e-cigarettes or smokeless tobacco and rarely in the diet or in the general human environment. Thus, we hypothesized that CEMA is an excellent biomarker of combusted tobacco product use. AIMS AND METHODS: We tested this hypothesis by analyzing CEMA in the urine of 1259 cigarette smokers (urinary cotinine…

  DOI

• A PSMA-Targeted Tri-Specific Killer Engager Enhances NK Cell Cytotoxicity against Prostate Cancer

  Cancer Immunology Research · 2024-11-15 · 8 citations

  articleOpen access

  NK cell tumor infiltration is associated with good prognosis in patients with metastatic castration-resistant prostate cancer (mCRPC). NK cells recognize and kill targets by a process called natural cytotoxicity. We hypothesized that promoting an antigen-specific synapse with coactivation may enhance NK cell function in mCRPC. We describe a tri-specific killer engager (TriKE) construct that engages with the activating receptor CD16 on NK cells and prostate-specific membrane antigen (PSMA) on mCR…

  PublisherOA PDFDOI

• UVR-sensor wearable device intervention to improve sun behaviors and reduce sunburns in melanoma survivors: study protocol of a parallel-group randomized controlled trial

  Trials · 2020 · 5 citations

  BACKGROUND: Individuals who have been diagnosed with melanoma have more than a 9-fold increased risk of developing another melanoma. Ultraviolet radiation (UVR) exposure following a melanoma diagnosis can be modified to reduce risk of a new melanoma diagnosis. Yet research shows that many melanoma survivors do not report optimal sun protection practices. The objective of this study is to evaluate the effectiveness of a UVR-sensor wearable device to improve sun protection behaviors and reduce sun…

  DOI

Recent grants

• Statistical methods for bivariate alternating recurrent event data

  NIH · $143k · 2017–2019

• Evaluating New Nicotine Standards for Cigarettes

  NIH · $126.0M · 2011–2025

• Statistical Methods for Analyzing Data of Recurrent Infections after Hematopoieti

  NIH · $143k · 2014–2016

Frequent coauthors

• Daniel J. Weisdorf

  University of Minnesota

  61 shared

• Dorothy K. Hatsukami

  55 shared

• Ranjana Mitra

  46 shared

• David A. Potter

  46 shared

• Monica Milani

  46 shared

• Ian A. Blair

  University of Pennsylvania

  43 shared

• Dafydd G. Thomas

  University of Michigan–Ann Arbor

  42 shared

• Clementina Mesaros

  41 shared

Labs

• Xianghua Luo LabPI

Education

• PhD, Department of Biostatistics, Bloomberg School of Public Health

  Johns Hopkins University

  2006

Awards & honors

• Member, Delta Omega Honorary Society in Public Health

Similar researchers at University of Minnesota

• Weihua Guanh-52
• Joseph Koopmeinersh-46
• Anne Eatonh-36