X. Sherry Liu

About

Xiaowei Sherry Liu, PhD, is an Associate Professor of Orthopaedic Surgery at the University of Pennsylvania's Perelman School of Medicine. She is affiliated with the Department of Orthopaedic Surgery and is part of the McKay Orthopaedic Research Laboratory. Her research focuses on bone biology, biomechanics, and the effects of various conditions and treatments on bone microarchitecture and strength. Dr. Liu's work includes studying bone resorption, the impact of inflammatory cytokines on bone, and the effects of pharmacological interventions on bone loss. She has contributed to understanding the cellular and molecular mechanisms underlying bone health and disease, with a particular emphasis on osteoporosis and related conditions.

Research topics

• Medicine
• Materials science
• Internal medicine
• Biomedical engineering
• Anatomy

Selected publications

• Mediation of Cartilage Matrix Degeneration and Fibrillation by Decorin in Post‐traumatic Osteoarthritis

  Arthritis & Rheumatology · 2020-03-12 · 66 citations

  articleOpen access

  Objective To elucidate the role of decorin, a small leucine‐rich proteoglycan, in the degradation of cartilage matrix during the progression of post‐traumatic osteoarthritis ( OA ). Methods Three‐month–old decorin‐null (Dcn −/− ) and inducible decorin‐knockout (Dcn i KO ) mice were subjected to surgical destabilization of the medial meniscus ( DMM ) to induce post‐traumatic OA . The OA phenotype that resulted was evaluated by assessing joint morphology and sulfated glycosaminoglycan ( sGAG ) sta…

  PublisherOA PDFDOI

• Lactation alters fluid flow and solute transport in maternal skeleton: A multiscale modeling study on the effects of microstructural changes and loading frequency

  Bone · 2021-06-05 · 26 citations

  articleOpen access
  PublisherOA PDFDOI

• The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

  eLife · 2021-06-03 · 22 citations

  articleOpen access

  Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using a Gli1 reporter line, we found that Gli1 + cells contribute to the development of meniscus horns from 2 weeks of age. In adult mice, Gli1 + cells resided at the superficial layer of meniscus and expressed known mesenchymal progenitor markers. In culture, meniscal Gli1 + cells possessed high progenitor activities under the control of Hh signal. Meniscus injury at the anterior…

  PublisherDOI

• Activating EGFR Signaling Attenuates Osteoarthritis Development Following Loading Injury in Mice

  Journal of Bone and Mineral Research · 2020-12-01 · 22 citations

  articleOpen access

  Posttraumatic osteoarthritis (PTOA) results in joint pain, loss of joint function, and impaired quality of daily life in patients with limited treatment options. We previously demonstrated that epidermal growth factor receptor (EGFR) signaling is essential for maintaining chondroprogenitors during articular cartilage development and homeostasis. Here, we used a nonsurgical, loading-induced PTOA mouse model to investigate the protective action of EGFR signaling. A single bout of cyclic tibial loa…

  PublisherOA PDFDOI

• Maternal bone adaptation to mechanical loading during pregnancy, lactation, and post-weaning recovery

  Bone · 2021-06-05 · 17 citations

  articleOpen accessSenior authorCorresponding
  PublisherOA PDFDOI

Recent grants

• Histology Core

  NIH · $17.0M · 2016–2026

• Roles of Modeling- and Remodeling-based Bone Formation in Determining Trabecular Bone Mechanics at Multiple Length Scales

  NSF · $375k · 2017–2021

• Effects of reproduction and lactation on postmenopausal bone health.

  NIH · $1.8M · 2017–2023

Frequent coauthors

• X. Edward Guo

  Hebei University of Technology

  49 shared

• Elizabeth Shane

  Columbia University Irving Medical Center

  24 shared

• Donald J. McMahon

  Hospital for Special Surgery

  24 shared

• Chantal M. J. de Bakker

  23 shared

• Ling Qin

  22 shared

• Bin Zhou

  Columbia University

  19 shared

• Xia Guo

  Chengdu Third People's Hospital

  15 shared

• Emily M. Stein

  Hospital for Special Surgery

  15 shared

Labs

• McKay Orthopaedic Research LaboratoryPI

Similar researchers at University of Pennsylvania

• Lachlan J. Smithh-42
• Andrew F. Kuntzh-22