William Altemeier

About

William A. Altemeier, M.D., is a board-certified physician specializing in pulmonary and respiratory disease care, with a focus on critical care medicine and smoking-related chronic lung disease. He is a professor of Pulmonary, Critical Care, and Sleep Medicine and Medicine at the University of Washington, and also serves as an adjunct professor of Pathology. Dr. Altemeier is an affiliate investigator at the Fred Hutchinson Cancer Research Center. His research interests include transcriptional regulation during acute lung injury. He earned his M.D. at Vanderbilt University and is board certified in Critical Care Medicine and Pulmonary Disease. Dr. Altemeier is actively involved in clinical care at the General Pulmonary Clinic at UW Medical Center and Fred Hutchinson Cancer Center, and he strives to create active partnerships with his patients to achieve the best possible outcomes. Outside of his professional work, he enjoys reading, bicycling, and hiking.

Research topics

• Internal medicine
• Medicine
• Pathology
• Biology
• Immunology
• Cardiology
• Anesthesia
• Intensive care medicine

Selected publications

• Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report

  American Journal of Respiratory Cell and Molecular Biology · 2022 · 270 citations

  ) physiologic dysfunction. For each domain, we present "relevant measurements," defined as those proposed by at least 30% of respondents. We propose that experimental ALI encompasses a continuum of models ranging from those focusing on gaining specific mechanistic insights to those primarily concerned with preclinical testing of novel therapeutics or interventions. We suggest that mechanistic studies may justifiably focus on a single domain of lung injury, but models must document alterations of…

  PublisherOA PDFDOI

• Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma

  European Respiratory Journal · 2022 · 60 citations

  BACKGROUND: Eosinophils are implicated as effector cells in asthma, but the functional implications of the precise location of eosinophils in the airway wall is poorly understood. We aimed to quantify eosinophils in the different compartments of the airway wall and associate these findings with clinical features of asthma and markers of airway inflammation. METHODS: In this cross-sectional study, we utilised design-based stereology to accurately partition the numerical density of eosinophils in…

  DOI

• Lung pericytes as mediators of inflammation

  American Journal of Physiology-Lung Cellular and Molecular Physiology · 2023-05-03 · 32 citations

  reviewOpen accessSenior author

  Pericytes are microvascular mural cells that directly contact endothelial cells. They have long been recognized for their roles in vascular development and homeostasis, but more recently have been identified as key mediators of the host response to injury. In this context, pericytes possess a surprising degree of cellular plasticity, behaving dynamically when activated and potentially participating in a range of divergent host responses to injury. Although there has been much interest in the rol…

  PublisherOA PDFDOI

• Circulating markers of inflammation and angiogenesis and clinical outcomes across subtypes of pulmonary arterial hypertension

  The Journal of Heart and Lung Transplantation · 2022 · 29 citations

  PublisherOA PDFDOI

• Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity

  Critical Care Explorations · 2022-12-30 · 19 citations

  articleOpen access

  IMPORTANCE: Vascular dysfunction and capillary leak are common in critically ill COVID-19 patients, but identification of endothelial pathways involved in COVID-19 pathogenesis has been limited. Angiopoietin-like 4 (ANGPTL4) is a protein secreted in response to hypoxic and nutrient-poor conditions that has a variety of biological effects including vascular injury and capillary leak. OBJECTIVES: To assess the role of ANGPTL4 in COVID-19–related outcomes. DESIGN, SETTING, AND PARTICIPANTS: Two hun…

  PublisherDOI

Recent grants

• NIH Grant K08HL071020

  NIH · $629k · 2008

• Impact of versican deficiency on the innate immune response to influenza virus

  NIH · $3.1M · 2017–2023

• NIH Grant R01HL086883

  NIH · $2.2M · 2014

Frequent coauthors

• Gustavo Matute‐Bello

  University of Washington

  50 shared

• W. Conrad Liles

  University of Washington

  38 shared

• Peter M. Vietze

  Montclair State University

  34 shared

• Charles W. Frevert

  University of Washington

  31 shared

• Sina A. Gharib

  University of Washington Medical Center

  30 shared

• Teal S. Hallstrand

  University of Washington

  30 shared

• Scott E. Sinclair

  Government of Manitoba

  30 shared

• Kathryn B. Sherrod

  Vanderbilt University

  29 shared

Labs

• UW Medicine Pulmonary and Respiratory Disease CarePI

Education

• M.D.

  Vanderbilt University School of Medicine

  1992

• Bachelor of Engineering, Chemical Engineering/Biomedical Engineering

  Vanderbilt University

  1986

Similar researchers at University of Washington

• Charles E. Alpersh-112
• Cynthia A. Derdeynh-55
• Geoffrey S. Bairdh-35