W. Mark Saltzman

About

W. Mark Saltzman is a Sterling Professor of Biomedical Engineering at Yale University, with additional appointments in Chemical & Environmental Engineering, Materials Science, Cellular & Molecular Physiology, and Dermatology. His research is motivated by the desire to create safer and more effective medical and surgical therapies, focusing on tissue engineering and drug delivery methods. His group has developed technology based on biocompatible polymeric materials for the controlled delivery of drugs, proteins, and genes, as well as new polymeric materials that influence tissue growth and assembly. Saltzman aims to develop economical, transportable, and accessible methods for disease prevention, emphasizing the importance of prevention over treatment. He is committed to training a new generation of chemical and biomedical engineers in a stimulating and collaborative environment that promotes the exchange of ideas and the integration of technology with modern biological science.

Research topics

• Biology
• Computational biology
• Biochemistry
• Chemistry
• Computer Science
• Medicine
• Materials science
• Biotechnology
• Pharmacology
• Nanotechnology

Selected publications

• Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses

  Science · 2022 · 332 citations

  The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the need for vaccines that not only prevent disease but also prevent transmission. Parenteral vaccines induce robust systemic immunity but poor immunity at the respiratory mucosa. We developed a vaccine strategy that we call "prime and spike," which leverages existing immunity generated by primary vaccination (prime) to elicit mucosal immune memory within the respiratory tract by using unadjuvanted intranas…

  DOI

• Polymeric vehicles for nucleic acid delivery

  Advanced Drug Delivery Reviews · 2020 · 210 citations

  Senior authorCorresponding
  DOI

• Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance

  Nature Biomedical Engineering · 2021 · 178 citations

  Senior authorCorresponding
  DOI

• The NIH Somatic Cell Genome Editing program

  Nature · 2021 · 130 citations

  The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) Consortium aims to accelerate the development of safer and more-effective methods to edit the genomes of disease-relevant somatic cells in patients, even in tissues that are difficult to reach. Here we discuss the consortium's plans to develop and benchmark approaches to induce and measure genome modifications…

  PublisherOA PDFDOI

• Branching in poly(amine-co-ester) polyplexes impacts mRNA transfection

  Biomaterials · 2024-06-27 · 11 citations

  articleOpen accessSenior authorCorresponding
  PublisherOA PDFDOI

Recent grants

• NIH Grant T32DK101019

  NIH · $1.2M · 2019

• NIH Grant R01DE014097

  NIH · $1.4M · 2007

• Nonenzymatic Gene Editing in Treatment of Heredity Spherocytosis

  NIH · $2.4M · 2019–2023

Frequent coauthors

• Peter M. Glazer

  42 shared

• Ranjit S. Bindra

  41 shared

• Hee‐Won Suh

  Dartmouth College

  36 shared

• Jordan S. Pober

  Yale University

  36 shared

• Christopher J. Cheng

  35 shared

• Elias Quijano

  Yale University

  34 shared

• Alexandra S. Piotrowski-Daspit

  28 shared

• Carmen J. Booth

  Yale University

  24 shared

Education

• Ph.D., Medical Engineering

  Massachusetts Institute of Technology

  1987

• S.M., Chemical Engineering

  Massachusetts Institute of Technology

  1984

• B.S., Chemical Engineering

  Iowa State University

  1981

Awards & honors

• Elected Member, National Academy of Engineering (2018)
• Founders Award, Controlled Release Society (2017)
• Chemical and Biological Engineering Hall of Fame, Iowa State…
• Elected Member, National Academy of Medicine (formerly Insti…
• Mines Medalist, South Dakota School of Mines (2014)

Similar researchers at Yale University

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• Paul Anastash-72
• Julie Zimmermanh-68