Vimal Selvaraj

About

Vimal Selvaraj is a Principal Investigator at the Selvaraj Laboratory of Integrative Physiology. His research focuses on molecular medicine, systems biology, reproductive technologies, and related fields. The laboratory is affiliated with Cornell University, where Vimal Selvaraj leads efforts in understanding complex biological systems and advancing reproductive health technologies.

Research topics

• Biology
• Genetics
• Cell biology
• Immunology
• Biochemistry

Selected publications

• Efficient induction and sustenance of pluripotent stem cells from bovine somatic cells

  Biology Open · 2021 · 33 citations

  Senior authorCorresponding

  Although derivation of naïve bovine embryonic stem cells is unachieved, the possibility for generation of bovine induced pluripotent stem cells (biPSCs) has been generally reported. However, attempts to sustain biPSCs by promoting self-renewal have not been successful. Methods established for maintaining murine and human induced pluripotent stem cells (iPSCs) do not support self-renewal of iPSCs for any bovid species. In this study, we examined methods to enhance complete reprogramming and concu…

  PublisherDOI

• RhoA/ROCK signaling antagonizes bovine trophoblast stem cell self-renewal and regulates preimplantation embryo size and differentiation

  Development · 2022 · 15 citations

  Senior authorCorresponding

  Exponential proliferation of trophoblast stem cells (TSC) is crucial in Ruminantia to maximize numerical access to caruncles, the restricted uterine sites that permit implantation. When translating systems biology of the undifferentiated bovine trophectoderm, we uncovered that inhibition of RhoA/Rock promoted self-renewing proliferation and substantially increased blastocyst size. Analysis of transcripts suppressed by Rock inhibition revealed transforming growth factor β1 (TGFβ1) as a primary up…

  PublisherOA PDFDOI

• Functional metabolite reserves and lipid homeostasis revealed by the MA-10 Leydig cell metabolome

  PNAS Nexus · 2022-09-01 · 13 citations

  articleOpen accessSenior author

  In Leydig cells, intrinsic factors that determine cellular steroidogenic efficiency is of functional interest to decipher and monitor pathophysiology in many contexts. Nevertheless, beyond basic regulation of cholesterol storage and mobilization, systems biology interpretation of the metabolite networks in steroidogenic function is deficient. To reconstruct and describe the different molecular systems regulating steroidogenesis, we profiled the metabolites in resting MA-10 Leydig cells. Our resu…

  PublisherOA PDFDOI

• Exogenous cholesterol acquisition signaling in LH-responsive MA-10 Leydig cells and in adult mice

  Journal of Endocrinology · 2022-07-27 · 12 citations

  articleOpen accessSenior author

  MA-10 cells, established 4 decades ago from a murine Leydig cell tumor, has served as a key model system for studying steroidogenesis. Despite a precipitous loss in their innate ability to respond to luteinizing hormone (LH), the use of a cell-permeable cAMP analog for induction ensured their continued use. In parallel, a paradigm that serum-free conditions are essential for trophic steroidogenic stimulation was rationalized. Through the selection of LH-responsive single-cell MA-10Slip clones, w…

  PublisherOA PDFDOI

• Arresting calcium-regulated sperm metabolic dynamics enables prolonged fertility in poultry liquid semen storage

  Scientific Reports · 2023-12-08 · 11 citations

  articleOpen access

  Abstract The preservation of liquid semen is pivotal for both industrial livestock production and genetic management/conservation of species with sperm that are not highly cryo-tolerant. Nevertheless, with regard to poultry semen, even brief in vitro storage periods can lead to a notable decline in fertility, despite the in vivo capacity to maintain fertility for several weeks when within the hen’s sperm storage tubules. For fertility in sperm, intracellular calcium ions ([Ca 2+ ]i) play a key r…

  PublisherOA PDFDOI

Recent grants

• Mechanism of cholesterol regulation by the mitochondrial translocator protein (TSPO)

  NIH · $1.6M · 2017–2024

Frequent coauthors

• Prasanthi P. Koganti

  Cornell University

  37 shared

• Viju Vijayan Pillai

  Purdue University West Lafayette

  34 shared

• Lan N. Tu

  33 shared

• Wenbin Deng

  Sun Yat-sen University

  25 shared

• Kasey M. Schalich

  Vanderbilt University Medical Center

  25 shared

• Atsushi Asano

  Kagoshima University

  24 shared

• Douglas M. Stocco

  Texas Tech University

  22 shared

• Kanako Morohaku

  Shinshu University

  21 shared

Labs

• Selvaraj Laboratory of Integrative PhysiologyPI

Education

• Other, Veterinary Medicine

  Not specified

• M.S., Immunology

  Not specified

• Ph.D., Reproductive Biology

  Not specified

• Other, Neuroscience/Regenerative Medicine

  Not specified

Similar researchers at Cornell University

• Xingen Leih-75
• Thomas Overtonh-58
• Julianna Kyungjune Leeh-47