About

Tyler J. Anderson, MD, is an Assistant Professor in the Departments of Psychiatry and Pediatrics at the University of Utah. He specializes in Pediatric Behavioral Health and Child & Adolescent Psychiatry. Dr. Anderson is board certified by the American Board of Psychiatry & Neurology in both Psychiatry and Child & Adolescent Psychiatry. His educational background includes undergraduate studies in Music at Snow College and Brigham Young University, a Master of Healthcare Administration from Pacific University, and an M.D. from the University of Colorado School of Medicine. He completed his residency in Psychiatry at the University of Colorado School of Medicine and a fellowship in Child & Adolescent Psychiatry at the University of Utah School of Medicine. His research includes work on the prevalence of substance use among adolescents and its association with academic achievement, as evidenced by his publication in the World Journal of Psychiatry.

Research topics

• Biology
• Medicine
• Computer Science
• Neuroscience
• Pathology
• Molecular biology
• Virology
• Immunology
• Genetics
• Computational biology

Selected publications

• Research on Multi-Task Natural Language Understanding and Generation Methods Based on Large Language Models

  Global Media and Social Sciences Research Journal · 2026-04-05

  articleOpen access

  The rapid evolution of large language models has fundamentally transformed the landscape of computational linguistics, enabling unprecedented capabilities across a diverse array of tasks. While historically natural language understanding and natural language generation were treated as disparate domains requiring specialized architectures, contemporary paradigms leverage unified models to concurrently execute classification, extraction, summarization, and open-ended text creation. This paper presents a comprehensive investigation into multi-task methods based on large language models, aiming to bridge the operational gap between understanding and generation objectives. We propose a novel algorithmic framework that mitigates negative transfer and gradient interference, phenomena frequently observed when optimizing models for competing downstream tasks. By introducing a dynamic task-weighting mechanism and a unified instruction-tuned formatting approach, our methodology aligns generative sequences with discriminative representation learning. We present extensive empirical analyses across established benchmarks, demonstrating that our approach significantly enhances parameter efficiency while achieving superior or competitive performance compared to single-task models. The findings illuminate the underlying mechanisms of shared representation spaces and provide critical insights for the deployment of versatile, multi-capable computational systems in complex real-world environments.

  PublisherOA PDFDOI

• A Multicentre Retrospective Review of Laterally Plated Partial Tarsal Arthrodesis in Dogs and Cats

  Veterinary and Comparative Orthopaedics and Traumatology · 2025-07-01

  article
  PublisherDOI

• A Case of Stress-Induced Cardiomyopathy After Ketamine Infusion

  Cureus · 2024-05-05 · 2 citations

  articleOpen access

  We report the case of a 64-year-old female with a history of hypothyroidism and isolated parotid sarcoidosis who presented with acute-onset chest pain and dyspnea. Echocardiogram demonstrated transiently reduced ejection fraction with apical hypokinesis, without evidence of obstructive coronary lesions on angiography, compatible with stress-induced cardiomyopathy. She received a ketamine infusion as a mental health treatment shortly before the development of symptoms, suggesting that this medication may have precipitated her cardiomyopathy. In recent years, ketamine has become a popular option for treating mental health disorders, including major depressive disorder and substance use disorders. It should be used with caution in patients with known cardiovascular disease, and its cardiac effects warrant further study.

  PublisherOA PDFDOI

• PO-2348 AI-based delineation for CBCT offline adaptive radiotherapy: an interexpert variability evaluation

  Radiotherapy and Oncology · 2023-05-01

  article
  PublisherDOI

• REGIONAL CHANGES IN MYOCARDIAL OXYGENATION IN WOMEN WITH ANGINA AND NON-OBSTRUCTIVE CORONARY ARTERY DISEASE

  Canadian Journal of Cardiology · 2023-10-01

  article
  PublisherDOI

• REGIONAL CHANGES IN MYOCARDIAL OXYGENATION IN WOMEN WITH ANGINA AND NON-OBSTRUCTIVE CORONARY ARTERY DISEASE

  Canadian Journal of Diabetes · 2023-10-25

  article
  PublisherDOI

• Frontmatter

  Edinburgh University Press eBooks · 2023

  • Computer Science
  • Computer Science

  Edinburgh Critical Studies in Shakespeare and Philosophy takes seriously the speculative and worldmaking properties of Shakespeare's art. Maintaining a broad view of 'philosophy' that accommodates first-order questions of metaphysics, ethics, politics and aesthetics, the series also expands our understanding of philosophy to include the unique kinds of theoretical work carried out by performance and poetry itself.

  DOI

• Targeted temperature management and PbtO2 in traumatic brain injury

  Brain and Spine · 2023-01-01 · 3 citations

  articleOpen access

  Targeted Temperature Management (TTM) to normothermia is widely used in traumatic brain injury (TBI). We investigated the effects to of TTM to normothermia patients with TBI (GCS≤12) monitored with multimodality monitoring, to better understand the physiological consequences of this intervention. In TBI patients cooled to normothermia and in which brain oxygenation deteriorates, are there changes in physiological parameters which are pertinent to brain oxygenation? 102 TBI patients with continuous recordings of intracranial pressure (ICP) and brain oxygen tension (PbtO2) were studied retrospectively. Non-continuous arterial carbon dioxide (PaCO2) and oxygen (PaO2) tensions, and core body temperature (Tc) were added. PaO2 and PaCO2 were also corrected for Tc. Transitions from elevated Tc to normothermia were identified in 39 patients. The 8 h pre and post the transition to normothermia were compared. Data is given as median [IQR] or mean (SD). Overall, normothermia reduced ICP (12 [9–18] −11 [8–17] mmHg, p < 0.009) and Tcore (38.3 [0.3]-36.9 [0.4] oC, p < 0.001), but not PbtO2 (23.3 [16.6]-24.4 [17.2–28.7] mmHg, NS). Normothermia was associated with a fall in PbtO2 in 18 patients (24.5 [9.3] −20.8 [7.6] mmHg). Only in those with a fall in PbtO2 with cooling did ICP (15 [10.8–18.5] −12 [7.8–17.3] mmHg, p = 0.002), and temperature corrected PaCO2 (5.3 [0.5]- 4.9 [0.8] kPa, p = 0.001) decrease. A reduction in PbtO2 was only present in the subgroup of patients with a fall in temperature corrected PaCO2 with cooling. This suggests that even modest temperature changes could result in occult hyperventilation in some patients. pH stat correction of ventilation may be an important factor to consider in future TTM protocols.

  PublisherDOI

• Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice

  Neurobiology of Disease · 2022 · 22 citations

  • Biology
  • Neuroscience
  • Medicine

  Huntington disease (HD) is a neurodegenerative disease caused by a trinucleotide repeat expansion in the HTT gene encoding an elongated polyglutamine tract in the huntingtin (HTT) protein. Expanded mutant HTT (mHTT) is toxic and leads to regional atrophy and neuronal cell loss in the brain, which occurs earliest in the striatum. Therapeutic lowering of mHTT in the central nervous system (CNS) has shown promise in preclinical studies, with multiple approaches currently in clinical development for HD. Quantitation of mHTT in the cerebrospinal fluid (CSF) is being used as a clinical pharmacodynamic biomarker of target engagement in the CNS. We have previously shown that the CNS is a major source of mHTT in the CSF. However, little is known about the specific brain regions and cell types that contribute to CSF mHTT. Therefore, a better understanding of the origins of CSF mHTT and whether therapies targeting mHTT in the striatum would be expected to be associated with significant lowering of mHTT in the CSF is needed. Here, we use complementary pharmacological and genetic-based approaches to either restrict expression of mHTT to the striatum or selectively deplete mHTT in the striatum to evaluate the contribution of this brain region to mHTT in the CSF. We show that viral expression of a mHTT fragment restricted to the striatum leads to detectable mHTT in the CSF. We demonstrate that targeted lowering of mHTT selectively in the striatum using an antisense oligonucleotide leads to a significant reduction of mHTT in the CSF of HD mice. Furthermore, using a transgenic mouse model of HD that expresses full length human mHTT and wild type HTT, we show that genetic inactivation of mHTT selectively in the striatum results in a significant reduction of mHTT in the CSF. Taken together, our data supports the conclusion that the striatum contributes sufficiently to the pool of mHTT in the CSF that therapeutic levels of mHTT lowering in the striatum can be detected by this measure in HD mice. This suggests that CSF mHTT may represent a pharmacodynamic biomarker for therapies that lower mHTT in the striatum.

  DOI

• Perioperative blood transfusion in major abdominal cancer surgery: a multi-centre service evaluation and national survey

  BJA Open · 2022-08-23 · 9 citations

  articleOpen access

  Anaemia is associated with complications and death after surgery. Perioperative red-cell transfusion triggers are not well defined in patients having oncological surgery, or with cardiovascular disease. We carried out a prospective multicentre cohort study and a clinician survey of UK transfusion practice in adult patients undergoing surgery for abdominal malignancy. The primary outcome was red cell transfusion. Secondary outcomes were transfusion trigger haemoglobin, incidence of complications, length of hospital stay, and acute hospital mortality. In this prospective cohort study, data were collected on 412 patients undergoing surgery for intrabdominal malignancy in 14 NHS hospitals. Twenty-two (5.2%) patients received preoperative, 42 (10.2%) intraoperative, and 52 (12.2%) postoperative red blood cell transfusion. The mean postoperative transfusion trigger was 75.3 g L−1, and the mean number of units of red blood cells transfused was 1.5 (standard deviation, 1.1). Seventeen (4.0%) patients had a documented postoperative troponin elevation. Five (1.2%) patients died within 30 days of surgery. In the survey, 117 clinicians submitted complete responses, of whom 62 (53%) indicated that a transfusion threshold of 70 g L−1 was appropriate: however, this decreased to six (5.1%) if there was evidence of recent cardiac ischaemia. There were 100 (86%) respondents who indicated equipoise for a trial of restrictive vs liberal transfusion, decreasing to 56% if there was coexisting cardiovascular disease. Many patients having oncological surgery receive red cell transfusion, the majority being given postoperatively. Restrictive transfusion practice is generally followed; however, variability exists especially in cardiovascular disease. Equipoise exists for a study of transfusion thresholds in this group.

  PublisherDOI

Frequent coauthors

• Ewan Fernie

  989 shared

• Simon Palfrey

  University of California, Santa Barbara

  989 shared

• Michael Witmore

  989 shared

• Paul Yachnin

  University of California, Irvine

  989 shared

• Madhavi Menon

  989 shared

• Kevin Curran

  989 shared

• Julia Reinhard Lupton

  Society for Renaissance Studies

  989 shared

• Katherine Gillen

  891 shared

Labs

• University of Utah HealthPI

Education

• M.D.

  University of Utah

• B.S.

  University of Utah