Tonisha White

The genetic architecture of the human cerebral cortex

Science · 2020 · 871 citations

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci a…

Data sharing and privacy issues in neuroimaging research: Opportunities, obstacles, challenges, and monsters under the bed

Human Brain Mapping · 2020-07-04 · 178 citations

Collaborative networks and data sharing initiatives are broadening the opportunities for the advancement of science. These initiatives offer greater transparency in science, with the opportunity for external research groups to reproduce, replicate, and extend research findings. Further, larger datasets offer the opportunity to identify homogeneous patterns within subgroups of individuals, where these patterns may be obscured by the heterogeneity of the neurobiological measure in smaller samples.…

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Nature Communications · 2020 · 107 citations

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic…

Gender Diversity and Mental Health in Young People

Cambridge University Press eBooks · 2025-10-30 · 1 citations

Prenatal folate, homocysteine and vitamin B12 levels and child brain volumes, cognitive development and psychological functioning: the Generation R Study – CORRIGENDUM

British Journal Of Nutrition · 2026-02-02