Tilak Ratnanather
· Associate Research ProfessorJohns Hopkins University · Radiology and Radiological Science
Active 1990–2026
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About
Tilak Ratnanather is an Associate Research Professor of Biomedical Engineering at Johns Hopkins University. His research focuses on the analysis of brain structures such as the hippocampus, cingulate gyrus, planum temporale, superior temporal gyrus, and the auditory and prefrontal cortexes. These structures are implicated in neuropsychiatric and neurodevelopmental disorders including schizophrenia, Alzheimer's disease, epilepsy, major depression, and speech and language processing. His interests also extend to the physiological fluid mechanics of the cochlear outer hair cell, the study of nonlinear partial differential equations in computational anatomy and bioacoustics, and continuing education through online courses in applied mathematics.
Selected publications
NeuroImage · 2021-02-05 · 67 citations
reviewOpen accessHearing loss is a heterogeneous disorder thought to affect brain reorganization across the lifespan. Here, structural alterations of the brain due to hearing loss are assessed by using unique effect size metrics based on Cohen's d and Hedges' g. These metrics are used to map coordinates of gray matter (GM) and white matter (WM) alterations from bilateral congenital and acquired hearing loss populations. A systematic review and meta-analysis revealed m = 72 studies with structural alterations mea…
NeuroImage · 2021-01-14 · 57 citations
reviewOpen accessScientific research aims to bring forward innovative ideas and constantly challenges existing knowledge structures and stereotypes. However, women, ethnic and cultural minorities, as well as individuals with disabilities, are systematically discriminated against or even excluded from promotions, publications, and general visibility. A more diverse workforce is more productive, and thus discrimination has a negative impact on science and the wider society, as well as on the education, careers, an…
Longitudinal imaging highlights preferential basal ganglia circuit atrophy in Huntington’s disease
Brain Communications · 2023-01-01 · 22 citations
articleOpen access), coding for polyglutamine in the Huntingtin protein, with longer CAG repeats causing earlier age of onset. The variable 'Age' × ('CAG'-L), where 'Age' is the current age of the individual, 'CAG' is the repeat length and L is a constant (reflecting an approximation of the threshold), termed the 'CAG Age Product' (CAP) enables the consideration of many individuals with different CAG repeat expansions at the same time for analysis of any variable and graphing using the CAG Age Product score as th…
Radiology · 2025-09-01 · 7 citations
articleOpen accessTissue magnetic susceptibility elevations measured at MRI in the entorhinal cortex and putamen were significant predictors of onset of mild cognitive impairment and cognitive decline in cognitively unimpaired older adults, especially those with amyloid neuropathologic abnormalities.
Aperture Neuro · 2024-05-23 · 6 citations
articleOpen accessBackground: The vestibular system is associated with alterations in the structure and function of the central nervous system. Yet, whether age-related vestibular loss is related to volume loss in the cerebral cortical areas that have been reported to receive vestibular input remains unknown. In this cross-sectional study of 117 healthy, older adults from the Baltimore Longitudinal Study of Aging, we examine the relationships between age-related vestibular functions and the gray matter volumes of…
Awards & honors
- 2023 Diversity Recognition Award from the Johns Hopkins Dive…
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