Tianyi Li

About

Tianyi Li is an Assistant Professor in the Department of Computer and Information Technology at Purdue University. Her research focuses on human-computer interaction (HCI) systems, where she creates AI-infused, community-centered interfaces that empower human–AI teams to address domain-specific decisions. Her work integrates design, experimental, and computational methods to understand users, build collective intelligence through crowdsourcing, and facilitate and evaluate human-AI interactions. She holds a Ph.D. in Computer Science from Virginia Tech, earned in 2020, and a B.Eng. in Computer Science from The University of Hong Kong, earned in 2015. Tianyi Li is actively seeking students interested in the intersection of HCI, computing education, and intelligent user interfaces, encouraging those from diverse backgrounds such as computer science, psychology, engineering, and related disciplines to join her research group.

Research topics

• Cell biology
• Materials science
• Biology
• Chemistry
• Immunology
• Nanotechnology
• Genetics
• Internal medicine
• Organic chemistry
• Biochemistry

Selected publications

• Biodistribution and Non-linear Gene Expression of mRNA LNPs Affected by Delivery Route and Particle Size

  Pharmaceutical Research · 2022 · 200 citations

  DOI

• Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives

  Pharmaceutical Research · 2021 · 97 citations

  Senior authorCorresponding
  DOI

• Paclitaxel Drug Delivery Systems: Focus on Nanocrystals’ Surface Modifications

  Polymers · 2022 · 65 citations

  Senior authorCorresponding

  Paclitaxel (PTX) is a chemotherapeutic agent that belongs to the taxane family and which was approved to treat various kinds of cancers including breast cancer, ovarian cancer, advanced non-small-cell lung cancer, and acquired immunodeficiency syndrome (AIDS)-related Kaposi's sarcoma. Several delivery systems for PTX have been developed to enhance its solubility and pharmacological properties involving liposomes, nanoparticles, microparticles, micelles, cosolvent methods, and the complexation wi…

  DOI

• Multiphysics-Informed Pharmacokinetic Modeling of Systemic Exposure of Intramuscularly Injected LNPs

  Molecular Pharmaceutics · 2023-11-02 · 13 citations

  articleSenior authorCorresponding

  Lipid nanoparticle (LNP) constructs have been widely developed for gene therapy delivery. Understanding local absorption and presystemic clearance kinetics of LNPs, however, remains limited. This subsequently restrains the prediction and assessment of the systemic exposure of locally injected LNPs. As such, a multiscale computational approach was developed by integrating multiphysics simulation of intramuscular absorption kinetics of LNPs with whole-body pharmacokinetics modeling, bridged by a p…

  PublisherDOI

• Multiphysics modeling and simulation of local transport and absorption kinetics of intramuscularly injected lipid nanoparticles

  Journal of Controlled Release · 2023-06-11 · 13 citations

  articleSenior authorCorresponding
  PublisherDOI

Recent grants

• Toward Building a Crystal Structure Prediction Framework

  NSF · $126k · 2012–2014

• Toward Building a Crystal Structure Prediction Framework

  NSF · $390k · 2010–2013

• CAREER: Towards Fundamental Understanding and Rational Control of Crystal Growth

  NSF · $496k · 2005–2010

Frequent coauthors

• Sihui Long

  Wuhan Institute of Technology

  187 shared

• Sean Parkin

  University of Kentucky

  115 shared

• Mingtao Zhang

  79 shared

• Faquan Yu

  76 shared

• Yunping Zhoujin

  Wuhan Institute of Technology

  56 shared

• Panpan Zhou

  Lanzhou University

  53 shared

• Peng‐Yu Liang

  State Key Laboratory of Applied Organic Chemistry

  32 shared

• S. Parkin

  Max Planck Institute of Microstructure Physics

  29 shared

Education

• Ph.D., Industrial and Physical Pharmacy

  Purdue University System

Awards & honors

• Polytechnic faculty members recognized for $1M+ awards in 20…
• Polytechnic research awards - July 2024
• Polytechnic research awards - June 2024

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