Thomas Gilmore

About

Professor Thomas D. Gilmore is a faculty member at Boston University, serving as a Professor of Biology. He is the Principal Investigator of The Gilmore Lab, which focuses on NF-kB transcription factors. His research involves studying the roles of NF-κB pathway components in various biological processes, including immune responses, symbiosis, and disease mechanisms. The lab investigates NF-kB target genes, protein-protein interactions, and physiological mediators related to NF-kB signaling. Professor Gilmore's work contributes to understanding the molecular functions of NF-kB in health and disease, and he collaborates with graduate and undergraduate students as well as recent graduates engaged in related research projects.

Research topics

• Biology
• Computer Science
• Genetics
• Evolutionary biology
• Immunology
• Biochemistry
• Cell biology
• Cancer research
• Ecology
• Biophysics

Selected publications

• Looking Down on NF-<i>κ</i>B

  Molecular and Cellular Biology · 2020 · 130 citations

  Senior authorCorresponding

  and some choanoflagellates. Herein, we review what is known about basal NF-κBs and how that knowledge informs on the evolution and conservation of key sequences and domains in NF-κB, as well as the regulation of NF-κB activity. The structures and DNA-binding activities of basal NF-κB proteins resemble those of mammalian NF-κB p100 proteins, and their posttranslational activation appears to have aspects of both canonical and noncanonical pathways in mammals. Several studies suggest that the singl…

  DOI

• Scaffold proteins as dynamic integrators of biological processes

  Journal of Biological Chemistry · 2022 · 51 citations

  Senior authorCorresponding

  Scaffold proteins act as molecular hubs for the docking of multiple proteins to organize efficient functional units for signaling cascades. Over 300 human proteins have been characterized as scaffolds, acting in a variety of signaling pathways. While the term scaffold implies a static, supportive platform, it is now clear that scaffolds are not simply inert docking stations but can undergo conformational changes that affect their dependent signaling pathways. In this review, we catalog scaffold…

  PublisherOA PDFDOI

• NF-κB and Human Cancer: What Have We Learned over the Past 35 Years?

  Biomedicines · 2021 · 41 citations

  1st authorCorresponding

  Transcription factor NF-κB has been extensively studied for its varied roles in cancer development since its initial characterization as a potent retroviral oncogene. It is now clear that NF-κB also plays a major role in a large variety of human cancers, including especially ones of immune cell origin. NF-κB is generally constitutively or aberrantly activated in human cancers where it is involved. These activations can occur due to mutations in the NF-κB transcription factors themselves, in upst…

  DOI

• Starvation differentially affects gene expression, immunity and pathogen susceptibility across symbiotic states in a model cnidarian

  Proceedings of the Royal Society B Biological Sciences · 2024-02-27 · 16 citations

  articleOpen accessCorresponding

  Mutualistic symbioses between cnidarians and photosynthetic algae are modulated by complex interactions between host immunity and environmental conditions. Here, we investigate how symbiosis interacts with food limitation to influence gene expression and stress response programming in the sea anemone Exaiptasia pallida (Aiptasia). Transcriptomic responses to starvation were similar between symbiotic and aposymbiotic Aiptasia; however, aposymbiotic anemone responses were stronger. Starved Aiptasi…

  PublisherOA PDFDOI

• A conserved core region of the scaffold NEMO is essential for signal-induced conformational change and liquid-liquid phase separation

  Journal of Biological Chemistry · 2023-10-27 · 12 citations

  articleOpen accessSenior authorCorresponding

  Scaffold proteins help mediate interactions between protein partners, often to optimize intracellular signaling. Herein, we use comparative, biochemical, biophysical, molecular, and cellular approaches to investigate how the scaffold protein NEMO contributes to signaling in the NF-κB pathway. Comparison of NEMO and the related protein optineurin from a variety of evolutionarily distant organisms revealed that a central region of NEMO, called the Intervening Domain (IVD), is conserved between NEM…

  PublisherOA PDFDOI

Recent grants

• NF-kappaB in Cnidarian Development

  NSF · $895k · 2014–2021

• NIH Grant R29CA047763

  NIH · $546k · 1993

• REU Site: Interplay between Genes and the Environment

  NSF · $476k · 2013–2018

Frequent coauthors

• George Mosialos

  Aristotle University of Thessaloniki

  23 shared

• David M. Davidson

  16 shared

• Bakary S. Sylla

  Centre International de Recherche sur le Cancer

  16 shared

• Nikolay Malinin

  16 shared

• Eudoxia Hatzivassiliou

  Aristotle University of Thessaloniki

  16 shared

• John R. Finnerty

  16 shared

• David Wallach

  16 shared

• Siu Chun Hung

  University of Hong Kong

  16 shared

Labs

• The Gilmore LabPI

Education

• Post-doc, McArdle Laboratory for Cancer Research

  University of Wisconsin Madison

  1987

• PhD, Zoology

  University of California Berkeley

  1984

• AB, English

  Princeton University

  1974

Similar researchers at Boston University

• David J. Waxmanh-97
• Jerry Chenh-96
• Richard B. Primackh-83