Thomas Bifano

About

Thomas Bifano, PhD, is a Professor in the Department of Mechanical Engineering at Boston University and the Director of the Photonics Center (BUPC). He has a primary appointment in Mechanical Engineering and has served as Chair of the Manufacturing Engineering Department from 1999 to 2006. Dr. Bifano directs the Boston University Photonics Center, a core facility and academic center of excellence that includes faculty from eight academic departments and staff members. His leadership involves overseeing programs for education, scholarly research, and the development of advanced photonic device prototypes for both commercial and military applications. He manages a state-of-the-art facility comprising shared research laboratories and a large business innovation center. His research focuses on modeling, design, production, and use of micro-electro-mechanical systems (MEMS) in optical applications, with specific interests in deformable mirrors, MEMS, adaptive optics, biphotonic microscopy, astronomical telescope instrumentation, and laser wavefront control. Dr. Bifano's affiliations extend across multiple departments and divisions, including Biomedical Engineering, Materials Science & Engineering, Electrical & Computer Engineering, and Neuroscience & Neuroengineering, among others.

Research topics

• Computer Science
• Materials science
• Physics
• Optics
• Acoustics
• Optoelectronics
• Biology
• Artificial Intelligence
• Embedded system
• Neuroscience

Selected publications

• Simultaneous multiplane imaging with reverberation two-photon microscopy

  Nature Methods · 2020 · 116 citations

  DOI

• An adaptive optics module for deep tissue multiphoton imaging in vivo

  Nature Methods · 2021 · 104 citations

  PublisherOA PDFDOI

• Auxetics‐Inspired Tunable Metamaterials for Magnetic Resonance Imaging

  Advanced Materials · 2021 · 47 citations

  Auxetics refers to structures or materials with a negative Poisson's ratio, thereby capable of exhibiting counterintuitive behaviors. Herein, auxetic structures are exploited to design mechanically tunable metamaterials in both planar and hemispherical configurations operating at megahertz (MHz) frequencies, optimized for their application to magnetic resonance imaging (MRI). Specially, the reported tunable metamaterials are composed of arrays of interjointed unit cells featuring metallic helice…

  PublisherOA PDFDOI

• Three-Photon Adaptive Optics for Mouse Brain Imaging

  Frontiers in Neuroscience · 2022 · 41 citations

  mouse brain imaging. We use a femtosecond source at 1300 nm to generate three-photon (3P) fluorescence in yellow fluorescent protein (YFP) labeled mouse brain and a microelectromechanical (MEMS) SLM to apply different Zernike phase patterns. The 3P fluorescence signal is used as feedback to calculate the amount of phase correction without direct phase measurement. We show signal improvement in the cortex and the hippocampus at greater than 1 mm depth and demonstrate close to diffraction-limited…

  PublisherOA PDFDOI

• Induced pluripotent stem cell-derived cardiomyocyte in vitro models: benchmarking progress and ongoing challenges

  Nature Methods · 2024-11-08 · 31 citations

  reviewOpen access
  PublisherOA PDFDOI

Recent grants

• IUCRC Collaborative Research: I/UCRC: Center for Biophotonic Sensors and Systems (CBSS)

  NSF · $480k · 2011–2017

• Phase II I/UCRC Trustees of Boston University: Center on Biophotonic Sensors and Systems

  NSF · $102k · 2017–2018

Frequent coauthors

• Paul Bierden

  Boston Micromachines (United States)

  39 shared

• Steven Cornelissen

  Boston Micromachines (United States)

  35 shared

• Jérôme Mertz

  30 shared

• Yang Lu

  24 shared

• Hari P. Paudel

  National Energy Technology Laboratory

  24 shared

• Jason B. Stewart

  K Lab (United States)

  23 shared

• T. A. Dow

  North Carolina State University

  22 shared

• Bennett B. Goldberg

  Boston University

  20 shared

Education

• Ph.D., Electrical Engineering

  Boston University

  1997

• M.S., Electrical Engineering

  Boston University

  1993

• B.S., Electrical Engineering

  University of Massachusetts Amherst

  1991

Similar researchers at Boston University

• David Boash-156
• Samagya Banskotah-25