About

Tatiana V Brown, M.D., earned her medical degree from the Moscow Medical Academy and completed her diagnostic radiology residency at the Moscow Oncology Medical Center. After immigrating to the United States, she completed her family practice residency program at the University of Oklahoma Health Sciences Center, where she was attracted to geriatric care. Dr. Brown has been involved in primary care medicine for several years and developed a love for Eastern medicine, completing an acupuncture course and actively using that knowledge in her practice. She currently serves as the Medical Director at UF Health Family Medicine – Normandy and is an Assistant Professor of Family Medicine at the University of Florida College of Medicine – Jacksonville. Her teaching profile includes courses such as Family Medicine and Ambulatory Care Clerkship. Dr. Brown speaks Russian, Spanish, and some German, and her interests include flamenco dancing, traveling, world history, and yoga as a prevention measure for musculoskeletal problems.

Research topics

• Political Science
• Intensive care medicine
• Internal medicine
• Medicine

Selected publications

• BASELINE CHARACTERISTICS FROM BONAPH1DE: A GLOBAL, OBSERVATIONAL, LONGITUDINAL STUDY OF PATIENTS WITH PRIMARY HYPEROXALURIA TYPE 1

  2024-09-25

  article

  Introduction: Primary hyperoxaluria type 1 (PH1) is a rare disease that causes oxalate overproduction, leading to kidney stones, nephrocalcinosis, kidney failure, and systemic oxalosis. Lumasiran is an approved RNAi PH1 treatment. We present baseline data from BONAPH1DE (N CT04982393), an ongoing observational study of the real-world safety and effectiveness of lumasiran. Methods: Patients with confirmed PH1 are eligible regardless of treatment status or liver transplant history and are man aged per routine clinical practice; no specific treatments, visits, or procedures are required. Data are collected retrospectively for up to 5 years pre-enrollment, at enrollment, and at least every 12 months for up to 7 years. Results: From December 13, 2021 to September 7, 2023, 77 patients from 6 countries were enrolled; lumasiran treatment history is currently unavailable for 6 patients (Table). At enrollment, 31% of the 62 lumasiran-treated patients reported pyridoxine use and 31% had a pyridoxine-responsive PH1 variant. Compared with patients never treated with lumasiran (N=9), lumasiran-treated patients were younger (mean [range] age, 15.5 [0.3–64.0] vs 44.0 [16.0–72.0] years), diagnosed earlier (8.2 [0.0–57.0] vs 26.9 [0.3–63.0] years), less likely to report history of kidney stones (44% vs 78%) or combined liver /kidney transplant (2% vs 44%), and more likely to be undergoing dialysis (13% vs 0%) or have nephrocalcinosis (44% vs 22%). Most (60%) lumasiran-treated patients had normal kidney function or stage 2 chronic kidney disease (CKD). Among all enrolled patients, 16% had stage 4 or 5 CKD; all were treated with lumasiran. Conclusion: Baseline BONAPH1DE data shows lumasiran use across all ages and the full range of CKD progression, ranging from normal kidney function to those undergoing dialysis. Ongoing enrollment and data collection will provide insights into lumasiran’s real-world safety and effectiveness.

  PublisherDOI

• Disease Manifestations, Treatment, and Healthcare Resource Use (HRU) in Primary Hyperoxaluria Type 1 (PH1): An International Online Chart Review Study

  Journal of the American Society of Nephrology · 2020

  • Political Science
  • Medicine
  • Intensive care medicine
  PublisherDOI

• Embedded contact knot homology and a surgery formula

  arXiv (Cornell University) · 2019-02-11

  preprintOpen access1st authorCorresponding

  Embedded contact knot homology (ECK) is a variation on Embedded contact homology (ECH), defined with respect to an open book decomposition compatible with a contact structure on some 3-manifold, M. The knot in question is given by the (null-homologous) binding of the open book and the chain complex is defined in terms of closed orbits of the Reeb vector field and certain pseudoholomorphic curves in the symplectization of the knot complement. In this thesis we first generalize this construction to the case of rational open book decompositions, allowing us to define ECK for rationally null-homologous knots. In its most general form this is a bi-filtered chain complex whose homology yields ECH of the closed manifold. There is also a hat version of ECK in this situation which is equipped with an Alexander grading equivalent to that in the Heegaard Floer setting, categorifies the Alexander polynomial, and is conjecturally isomorphic to the hat version of knot Floer homology, HFK. The main result of this thesis is a large negative n-surgery formula for ECK. Namely, we start with an (integral) open book decomposition of a manifold with binding K and compute, for large n, ECK of the knot K(-n) obtained by performing (-n)-surgery on K. This formula agrees with Hedden's large n-surgery formula for HFK, providing supporting evidence towards the conjectured equivalence between the two theories. Along the way, we also prove that ECK is, in many cases, independent of the choices made to define it, namely the almost complex structure on the symplectization and the homotopy type of the contact form. We also prove that, in the case of integral open book decompositions, the hat version of ECK is supported in Alexander gradings less than or equal to twice the genus of the knot.

  PublisherOA PDFDOI

• Embedded contact knot homology and a surgery formula

  Apollo (University of Cambridge) · 2018-05-11

  preprintOpen access1st authorCorresponding

  Embedded contact homology is an invariant of closed oriented contact 3-manifolds first defined by Hutchings, and is isomorphic to both Heegard Floer homology (by the work of Colin, Ghiggini and Honda) and Seiberg-Witten Floer cohomology (by the work of Taubes). The embedded contact chain complex is defined by counting closed orbits of the Reeb vector field and certain pseudoholomorphic curves in the symplectization of the manifold. As part of their proof that ECH=HF, Colin, Ghiggini and Honda showed that if the contact form is suitably adapted to an open book decomposition of the manifold, then embedded contact homology can be computed by considering only orbits and differentials in the complement of the binding of the open book; this fact was then in turn used to define a knot version of embedded contact homology, denoted ECK, where the (null-homologous) knot in question is given by the binding. In this thesis we start by generalizing these results to the case of rational open book decompositions, allowing us to define ECK for rationally null-homologous knots. In its most general form this is a bi-filtered chain complex whose homology yields ECH of the closed manifold. There is also a hat version of ECK in this situation which is equipped with an Alexander grading equivalent to that in the Heegaard Floer setting, categorifies the Alexander polynomial, and is conjecturally isomorphic to the hat version of knot Floer homology. The main result of this thesis is a large negative $n$-surgery formula for ECK. Namely, we start with an (integral) open book decomposition of a manifold with binding $K$ and compute, for all $n$ greater than or equal to twice the genus of $K$, ECK of the knot $K(-n)$ obtained by performing ($-n$)-surgery on $K$. This formula agrees with Hedden's large $n$-surgery formula for HFK, providing supporting evidence towards the conjectured equivalence between the two theories. Along we the way, we also prove that ECK is, in many cases, independent of the choices made to define it, namely the almost complex structure on the symplectization and the homotopy type of the contact form. We also prove that, in the case of integral open book decompositions, the hat version of ECK is supported in Alexander gradings less than or equal to twice the genus of the knot.

  PublisherOA PDFDOI

• Rare Case of Hematemesis: Calciphylaxis of the Esophagus

  Clinical Gastroenterology and Hepatology · 2017-05-03 · 7 citations

  articleOpen access
  PublisherOA PDFDOI

• The weekend effect: does time of admission impact management and outcomes of small bowel obstruction?

  Gastroenterology report · 2014-07-09 · 6 citations

  articleOpen accessSenior author

  AIMS: To determine whether day and time of admission influences the practice patterns of the admitting general surgeon and subsequent outcomes for patients diagnosed with small bowel obstruction. METHODS: A retrospective database review was carried out, covering patients admitted with the presumed diagnosis of partial small bowel obstruction from 2004-2011. RESULTS: A total of 404 patients met the inclusion criteria. One hundred and thirty-nine were admitted during the day, 93 at night and 172 on the weekend. Overall 30.2% of the patients were managed operatively with no significant difference between the groups (P = 0.89); however, of patients taken to the operating room, patients admitted during the day received operative intervention over 24 hours earlier than those admitted at a weekend, 0.79 days vs 1.90 days, respectively (P = 0.05). Overall mortality was low at 1.7%, with no difference noted between the groups (P = 0.35). Likewise there was no difference in morbidity rates between the three groups (P = 0.90). CONCLUSIONS: Despite a faster time to operative intervention in those patients admitted during the day, our study revealed that time of admission does not appear to correlate to patient outcome or mortality.

  PublisherOA PDFDOI

• Evidence-Based Clinical Reasoning in Medicine

  2013-02-01

  book1st authorCorresponding

  Medicine is still largely taught as an apprenticeship. Not until recently have medical students and physicians been taught to critically examine the evidence base behind medical management decisions. This book is perfect for students, not only because it will help them care for patients during their medicine subinternship rotation, but also because it will provide a valuable resource as they prepare for their end-of-rotation NBME shelf examination. The standard of care is constantly evolving, and the pace of its progress is increasing. A busy clinician has difficulty keeping up with the literature as it reports on the results of clinical trials and current expert consensus. Evidence-Based Clinical Reasoning in Medicine dissects many of the most controversial medical issues and landmark clinical trials that have and will continue to influence the practice of medicine.

  Publisher

• Hepatic Encephalopathy

  2012-04-16 · 6 citations

  other1st authorCorresponding

  Hepatic encephalopathy (HE) encompasses reversible neuropsychiatric symptoms caused by a buildup of gut derived toxins such as ammonia seen in patients with severe liver disease. Its symptoms range from clinically undetectable cognitive changes to overt coma. Patients with HE often have preserved intellectual and verbal abilities but have problems with sleepiness and attention. Precipitating factors like GI bleeding, dehydration, or infection significantly contribute to the development of overt episodes of HE. Early detection and treatment of these factors is an important part of therapy. Lactulose remains the mainstay of treatment of HE. Rifaximin, metronidazole, and other drugs are considered to be second line therapy, especially for patients with recurrent hospitalizations despite taking lactulose properly. One-year mortality is 60% after the first episode of overt HE. Appropriate candidates should be considered for liver transplantation.

  PublisherDOI

• Interaction of oral bacteria with gingival epithelial cell multilayers

  Molecular Oral Microbiology · 2011-03-28 · 108 citations

  articleOpen access

  Primary gingival epithelial cells were cultured in multilayers as a model for the study of interactions with oral bacteria associated with health and periodontal disease. Multilayers maintained at an air-liquid interface in low-calcium medium displayed differentiation and cytokeratin properties characteristic of junctional epithelium. Multilayers were infected with fluorescently labeled Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum or Streptococcus gordonii, and bacterial association was determined by confocal microscopy and quantitative image analysis. Porphyromonas gingivalis invaded intracellularly and spread from cell to cell; A. actinomycetemcomitans and F. nucleatum remained extracellular and showed intercellular movement through the multilayer; whereas S. gordonii remained extracellular and predominantly associated with the superficial cell layer. None of the bacterial species disrupted barrier function as measured by transepithelial electrical resistance. P. gingivalis did not elicit secretion of proinflammatory cytokines. However, A. actinomycetemcomitans and S. gordonii induced interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-6 and IL-8 secretion; and F. nucleatum stimulated production of IL-1β and TNF-α. Aggregatibacter actinomycetemcomitans, F. nucleatum and S. gordonii, but not P. gingivalis, increased levels of apoptosis after 24 h infection. The results indicate that the organisms with pathogenic potential were able to traverse the epithelium, whereas the commensal bacteria did not. In addition, distinct host responses characterized the interaction between the junctional epithelium and oral bacteria.

  PublisherOA PDFDOI

• Minimal Hepatic Encephalopathy and Driving: Is the Genie Out of the Bottle?

  The American Journal of Gastroenterology · 2011-08-01 · 19 citations

  article

  Prakash, Ravi K MD, MRCP; Brown, Thomas A MD; Mullen, Kevin D MD, FRCP Author Information

  PublisherDOI

Recent grants

• NIH Grant R01DE010963

  NIH · $1.8M · 2007

• NIH Grant R55DE010963

  NIH · $100k · 1996

• NIH Grant R01DE007322

  NIH · $239k · 1992

• NIH Grant K04DE000236

  NIH · $299k · 1993

Frequent coauthors

• Jiří Městecký

  20 shared

• Michael W. Russell

  University at Buffalo, State University of New York

  18 shared

• Steven L. McKnight

  15 shared

• David D. Thompson

  Alexion Pharmaceuticals (United States)

  13 shared

• Hua Zhu Ke

  Rutgers, The State University of New Jersey

  11 shared

• Catherine C. Thompson

  Pfizer (United States)

  9 shared

• Robert A. Burne

  University of Florida

  9 shared

• José A. Lemos

  University of Florida

  9 shared

Education

• M.D.

  Moscow Medical Academy

• Other, Diagnostic Radiology

  Moscow Oncology Medical Center

• Other, Family Practice

  University of Oklahoma Health Sciences Center