Tao Pan
· ProfessorUniversity of Chicago · Biochemistry and Molecular Biology
Active 1990–2025
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About
Tao Pan is a Professor of Biochemistry and Molecular Biology at the University of Chicago, with affiliations in the Committee on Genetics, Genomics and Systems Biology, and the Committee on Microbiology. His research focuses on the functional genomics and biology of tRNA, including its roles in microbiomes and translational regulation, as well as epitranscriptomics, which involves post-transcriptional RNA modifications. He has developed high throughput sequencing technologies to measure tRNA abundance, charging, and modifications, and investigates their roles in gene expression regulation and extra-translational functions in mammalian cells. His work on microbiome characterization includes the development of tRNA-seq to study microbiome activity and gene expression, revealing extensive variations in tRNA modification patterns that correlate with microbial protein expression. Additionally, he explores the dynamic regulation of mRNA modifications such as N6-methyladenosine (m6A), uncovering mechanisms by which these modifications influence mRNA structure, stability, and splicing, and their responses to the microbiome. His research extends to elucidating how mammalian host mRNA and tRNA modifications respond to the gut microbiome, demonstrating tissue-dependent reprogramming of epitranscriptomic marks. Tao Pan's background includes a PhD in Biophysics/Biochemistry from Yale University, postdoctoral work at the University of Colorado at Boulder, and a BS/MS in Chemistry from the…
Research topics
- Cancer research
- Internal medicine
- Biochemistry
- Medicine
- Chemistry
- Emergency medicine
- Biology
- Cell biology
- Virology
- Pediatrics
Selected publications
Elsevier eBooks · 2025-01-01
book-chapter
Recent grants
Mis-translation as a new mechanism of stress response in biology
NIH · $3.1M · 2011–2017
NIH · $1.2M · 2014
NIH · $3.0M · 2013
Frequent coauthors
- 88 shared
Venigalla B. Rao
- 44 shared
Junhua Dong
Huazhong Agricultural University
- 42 shared
Marthandan Mahalingam
Walter Reed Army Institute of Research
- 39 shared
Tobin R. Sosnick
University of Chicago
- 38 shared
Mengling Li
Fujian Medical University
- 37 shared
Jingen Zhu
Catholic University of America
- 36 shared
Jinyue Yang
Affiliated Hospital of Taishan Medical University
- 36 shared
Zhuangxia Miao
Huazhong Agricultural University
Education
- 1990
Ph.D., Biophysics/Biochemistry
Yale University
- 1986
Other, Chemistry
University des Saarlands
- 1993
Other, Biochemistry
University of Colorado at Boulder
Awards & honors
- American Association for the Advancement of Science (AAAS) F…
- NIH Director’s Pioneer award (2011 - 2016)
- NIH EUREKA award (2009 - 2013)
- American Cancer Society, Junior Faculty Research Award (1995…
- Cancer Research Foundation, Raymond F. Zelko Young Investiga…
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