Stuart Lindsay

About

Stuart Lindsay is a University Professor, Regents Professor, and Nadine and Edward Carson Presidential Chair of Physics and Chemistry at Arizona State University. He is the director of the Center for Single Molecule Biophysics in the Biodesign Institute and holds affiliations with the ASU-SFI Center for Biosocial Complex Systems, the Biodesign Center for Bioelectronics and Biosensors, and the Biosocial Complexity Initiative. Lindsay's research focuses on nano-scale biophysics, pioneering aspects of atomic force microscopy related to imaging and chemical analysis in water. His current research interests include nanoscale chemical mapping, applications of nanoscience for sustainable energy, new techniques for DNA and protein sequencing based on electron tunneling, and nanoscale probes of epigenetic markings and cell biochemistry. He holds 46 U.S. patents, has published over 200 research papers, and authored the standard text 'Introduction to Nanoscience'.

Research topics

• Biochemistry
• Chemistry
• Computer Science
• Chemical physics
• Crystallography
• Materials science
• Physical chemistry
• Biophysics
• Atomic physics
• Bioinformatics

Selected publications

• The emerging landscape of single-molecule protein sequencing technologies

  Nature Methods · 2021 · 357 citations

  PublisherOA PDFDOI

• Electronic Conductance Resonance in Non-Redox-Active Proteins

  Journal of the American Chemical Society · 2020 · 55 citations

  Senior authorCorresponding

  Bioelectronics research has mainly focused on redox-active proteins because of their role in biological charge transport. In these proteins, electronic conductance is a maximum when electrons are injected at the known redox potential of the protein. It has been shown recently that many non-redox-active proteins are good electronic conductors, though the mechanism of conduction is not yet understood. Here, we report single-molecule measurements of the conductance of three non-redox-active protein…

  DOI

• Measuring conductance switching in single proteins using quantum tunneling

  Science Advances · 2022-05-18 · 42 citations

  articleOpen access

  Interpreting the electrical signatures of single proteins in electronic junctions has facilitated a better understanding of the intrinsic properties of proteins that are fundamental to chemical and biological processes. Often, this information is not accessible using ensemble and even single-molecule approaches. In addition, the fabrication of nanoscale single-protein junctions remains challenging as they often require sophisticated methods. We report on the fabrication of tunneling probes, dire…

  PublisherOA PDFDOI

• Ubiquitous Electron Transport in Non-Electron Transfer Proteins

  Life · 2020 · 42 citations

  1st authorCorresponding

  Many proteins that have no known role in electron transfer processes are excellent electronic conductors. This surprising characteristic is not generally evident in bulk aggregates or crystals, or in isolated, solvated peptides, because the outer hydrophilic shell of the protein presents a barrier to charge injection. Ligands that penetrate this barrier make excellent electrical contacts, yielding conductivities on the order of a S/m. The Fermi Energy of metal electrodes is aligned with the ener…

  PublisherOA PDFDOI

• Electronic Transport in Molecular Wires of Precisely Controlled Length Built from Modular Proteins

  ACS Nano · 2022-01-14 · 38 citations

  articleOpen accessSenior authorCorresponding

  DNA molecular wires have been studied extensively because of the ease with which molecules of controlled length and composition can be synthesized. The same has not been true for proteins. Here, we have synthesized and studied a series of consensus tetratricopeptide repeat (CTPR) proteins, spanning 4 to 20 nm in length, in increments of 4 nm. For lengths in excess of 6 nm, their conductance exceeds that of the canonical molecular wire, oligo(phenylene-ethylenene), because of the more gradual dec…

  PublisherOA PDFDOI

Recent grants

• Recognition Tunneling for Single Molecule RNA Sequencing

  NIH · $1.8M · 2016–2020

• NIH Grant R21HG005851

  NIH · $868k · 2014

• NIH Grant RC2HG005625

  NIH · $1.7M · 2012

Frequent coauthors

• Larry A. Nagahara

  45 shared

• Jin He

  Florida International University

  40 shared

• Otto F. Sankey

  37 shared

• Peiming Zhang

  33 shared

• G. Ramachandran

  Bharathiar University

  33 shared

• Alex Primak

  Arizona State University

  30 shared

• Devens Gust

  Arizona State University

  22 shared

• Adam M. Rawlett

  21 shared

Labs

• Single Molecule BiophysicsPI

  The Biodesign Center for Single Molecule Biophysics has an extensive team of faculty and staff dedicated to discovery and innovation.

Education

• Ph.D., Physics

  University of Manchester, U.K.

  1976

• B.S., Physics

  University of Manchester, UK.

Awards & honors

• Fellow of the National Academy of Inventors
• Fellow of the American Physical Society
• Fellow of the American Association for the Advancement of Sc…
• Fellow of the Institute of Physics
• Global Futures Scientists and Scholars

Similar researchers at Arizona State University

• Jingyue Liuh-74
• Richard Kirianh-54
• Andrei Belitskyh-52