Steven T DeKosky

About

Steven T DeKosky is a prominent researcher in Alzheimer’s disease and traumatic brain injury, serving as the Deputy Director of the McKnight Brain Institute and a Professor of Neurology and Neuroscience at the University of Florida. He joined UF in July 2015 and has a distinguished background that includes roles such as vice president and dean of the University of Virginia School of Medicine, as well as chair of the department of neurology and director of the Alzheimer’s Disease Research Center at the University of Pittsburgh. His research focuses on understanding the neurochemistry, neuroimaging, treatment, and prevention of Alzheimer’s disease, with extensive contributions to the study of traumatic brain injury, including co-authoring the first report of dementia associated with TBI among professional football players. Dr. DeKosky completed his medical degree at the University of Florida, followed by a residency in neurology and a fellowship in neurochemistry, and has held academic and leadership positions at several prestigious institutions.

Research topics

• Medicine
• Psychology
• Neuroscience
• Computer Science
• Pathology
• Biology
• Pediatrics
• Intensive care medicine
• Clinical psychology
• Psychiatry

Selected publications

• The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

  Alzheimer s Research & Therapy · 2020 · 352 citations

  BACKGROUND: Synapse damage and loss are fundamental to the pathophysiology of Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to address the challenges of forging new clinical development approaches for AD therapeutics that can demonstrate reduction of synapse damage or loss. The key points of this review include the following: Synapse loss is a downstream effect of amyloidosis, tauopathy, inflammation, and other mechanisms occurring in AD.Synapse loss…

  DOI

• Diagnostic criteria for apathy in neurocognitive disorders

  Alzheimer s & Dementia · 2021 · 167 citations

  INTRODUCTION: Apathy is common in neurocognitive disorders (NCD) but NCD-specific diagnostic criteria are needed. METHODS: The International Society for CNS Clinical Trials Methodology Apathy Work Group convened an expert group and sought input from academia, health-care, industry, and regulatory bodies. A modified Delphi methodology was followed, and included an extensive literature review, two surveys, and two meetings at international conferences, culminating in a consensus meeting in 2019. R…

  DOI

• Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients

  Journal of Neurotrauma · 2020 · 83 citations

  1st authorCorresponding

  The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus attacks multiple organs of coronavirus disease 2019 (COVID-19) patients, including the brain. There are worldwide descriptions of neurological deficits in COVID-19 patients. Central nervous system (CNS) symptoms can be present early in the course of the disease. As many as 55% of hospitalized COVID-19 patients have been reported to have neurological disturbances three months after infection by SARS-CoV-2. The mutability of th…

  DOI

• Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults

  GeroScience · 2021 · 68 citations

  PublisherOA PDFDOI

• GLP-1RA and SGLT2i Medications for Type 2 Diabetes and Alzheimer Disease and Related Dementias

  JAMA Neurology · 2025-04-07 · 62 citations

  letterOpen access

  Importance: The association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) and risk of Alzheimer disease and related dementias (ADRD) remains to be confirmed. Objective: To assess the risk of ADRD associated with GLP-1RAs and SGLT2is in people with type 2 diabetes (T2D). Design, Setting, and Participants: This target trial emulation study used electronic health record data from OneFlorida+ Clinical Research Consortium from Jan…

  PublisherOA PDFDOI

Recent grants

• NIH Grant U01AT000162

  NIH · $37.7M · 2011

• Project 4 (Pitts)-Cholinergic and amyloid alteration in mild cognitive impairment

  NIH · $67.4M · 1997–2027

• NIH Grant P01NS030318

  NIH · $7.3M · 2012

Frequent coauthors

• Oscar L. López

  University of Pittsburgh

  339 shared

• William E. Klunk

  268 shared

• Chester A. Mathis

  University of Pittsburgh

  217 shared

• James T. Becker

  First Solar (United States)

  176 shared

• Ranjan Duara

  Florida College

  166 shared

• M. Ilyas Kamboh

  University of Pittsburgh

  159 shared

• Lewis H. Kuller

  University of Pittsburgh

  156 shared

• Julie C. Price

  Massachusetts General Hospital

  146 shared

Labs

• iBRAIN LabPI

Education

• M.D.

  University of Florida

  1974

• Other, Neurology

  University of Florida

• Other, Neurochemistry

  University of Virginia Center for Neurosciences

• Other, Psychology and Neuroscience

  University of Florida

Awards & honors

• Best Doctors in America 2003-2013

Similar researchers at University of Florida

• Matthew Farrerh-133
• Melissa Armstrongh-91
• David J Clarkh-64