Steven M. Dubinett
University of California, Los Angeles · Pharmacology and Pharmaceutical Sciences
Active 1987–2025
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About
Steven M. Dubinett is a distinguished professor and a key figure in the Department of Pharmacology at the University of California, Los Angeles. His research interests focus on the immune suppression in lung cancer, particularly the role of inflammation and immunity in the pathogenesis of pulmonary premalignancy. His work aims to improve early detection and cancer interception, and he conducts mechanism-based translational and clinical studies to evaluate combination immunotherapies for advanced non-small cell lung cancer. Dubinett's research program has been funded by notable organizations including Stand Up to Cancer, the NCI Moonshot Human Tumor Atlas Network, NCI Early Detection Research Network, NCI Molecular Characterization Laboratory Program, and CIRM. His background includes initial research at Massachusetts General Hospital, where he participated in the first clinical trial using tumor-infiltrating lymphocytes to treat cancer patients, observing significant responses in renal cancer and melanoma but not in lung cancer. Since joining UCLA in 1988, he has dedicated his career to understanding why lung cancer patients do not respond to immunotherapy, leading to significant contributions in the field of lung cancer immunology.
Research topics
- Medicine
- Internal medicine
- Pathology
- Gastroenterology
- Virology
- Oncology
- Immunology
Selected publications
JAMA Network Open · 2021-09-30 · 186 citations
articleOpen accessImportance: The COVID-19 pandemic has had disproportionate effects on racial and ethnic minority communities, where preexisting clinical and social conditions amplify health and social disparities. Many of these communities report lower vaccine confidence and lower receipt of the COVID-19 vaccine. Understanding factors that influence the multifaceted decision-making process for vaccine uptake is critical for narrowing COVID-19-related disparities. Objective: To examine factors that members of mu…
Nature Cancer · 2020 · 47 citations
Open Forum Infectious Diseases · 2020 · 13 citations
BACKGROUND: Interleukin-6 blockade (IL-6) has become a focus of therapeutic investigation for the coronavirus disease 2019 (COVID-19). METHODS: We report a case of a 34-year-old with COVID-19 pneumonia receiving an IL-6 receptor antagonist (IL-6Ra) who developed spontaneous colonic perforation. This perforation occurred despite a benign abdominal exam and in the absence of other known risk factors associated with colonic perforation. RESULTS: Examination of the colon by electron microscopy revea…
Cancer Cell · 2025-11-06 · 12 citations
articleCancer Research · 2025-04-21 · 1 citations
articleAbstract Background: Lung adenocarcinoma (LUAD) is one of the most prevalent and lethal cancer types worldwide. However, our understanding of the transition from normal-appearing tissue (NAT) to adenomatous lung premalignant lesions (aPMLs) and LUADs, particularly within a spatial context, remains limited. This study aims to address this gap by systemically analyzing the pathologic continuum of NAT > aPML > LUAD using spatial transcriptomics (ST). Methods: High-resolution spatial p…
Recent grants
Clinically Actionable Neoantigens in Non-Small Cell Lung Cancer
NIH · 2012–2021
The UCLA Pulmonary and Critical Care Medicine Scientist Training Program (PCCM-STP)
NIH · $8.0M · 2003–2030
NIH · $671k · 2010
Frequent coauthors
- 500 shared
Sherven Sharma
- 300 shared
Kostyantyn Krysan
- 221 shared
Tonya C. Walser
- 207 shared
Avrum Spira
Boston University
- 166 shared
David Elashoff
University of California, Los Angeles
- 149 shared
Marc E. Lenburg
Boston University
- 143 shared
Edward B. Garon
- 137 shared
Linh M. Tran
University of California, Los Angeles
Labs
Steven M. Dubinett LaboratoryPI
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