Steven Graham Adie
Cornell University · Aerospace Engineering
Active 2005–2026
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About
Dr. Steven Graham Adie is an Associate Professor at the Meinig School of Biomedical Engineering at Cornell University, where he is based in Weill Hall, Room 113. He joined Cornell in 2013 after completing a postdoctoral fellowship at the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign. His postdoctoral research focused on optical coherence tomography (OCT), including computational image formation, dynamic optical coherence elastography (OCE), and translational OCT research for image-guided surgery in breast cancer. Dr. Adie earned his Ph.D. in Electrical and Electronic Engineering from The University of Western Australia. Prior to his academic career, he worked in the R&D division of a startup developing solid-state laser systems for LASIK eye surgery. His research program centers on the development and application of OCT-based imaging for both basic science investigations and clinical applications. OCT is an imaging modality capable of 3D label-free imaging of tissue structure and function in vivo, functioning as the optical analogue of ultrasound with higher resolution. In his lab, Dr. Adie develops OCT instrumentation and imaging techniques to optimize resolution and contrast, including methods for optical coherence elastography to image tissue mechanical properties. His work explores new image formation paradigms for cellular-resolution volumetric OCT, leveraging computational approaches that combine the advantages…
Research topics
- Optics
- Computer science
- Medicine
- Materials science
- Physics
Selected publications
Advanced Functional Materials · 2020-05-04 · 55 citations
articleOpen accessObesity increases the risk and worsens the prognosis for breast cancer due, in part, to altered adipose stromal cell (ASC) behavior. Whether ASCs from obese individuals increase migration of breast cancer cells relative to their lean counterparts, however, remains unclear. To test this connection, multicellular spheroids composed of MCF10A-derived tumor cell lines of varying malignant potential and lean or obese ASCs were embedded into collagen scaffolds mimicking the elastic moduli of interstit…
Biomedical Optics Express · 2022-12-01 · 29 citations
reviewOpen accessSenior authorOptical elastography offers a rich body of imaging capabilities that can serve as a bridge between organ-level medical elastography and single-molecule biophysics. We review the methodologies and recent developments in optical coherence elastography, Brillouin microscopy, optical microrheology, and photoacoustic elastography. With an outlook toward maximizing the basic science and translational clinical impact of optical elastography technologies, we discuss potential ways that these techniques…
Nature Communications · 2022-06-16 · 19 citations
articleOpen accessSenior authorQuantitative characterisation of micro-scale mechanical properties of the extracellular matrix (ECM) and dynamic cell-ECM interactions can significantly enhance fundamental discoveries and their translational potential in the rapidly growing field of mechanobiology. However, quantitative 3D imaging of ECM mechanics with cellular-scale resolution and dynamic monitoring of cell-mediated changes to pericellular viscoelasticity remain a challenge for existing mechanical characterisation methods. Her…
Scientific Reports · 2021-02-02 · 18 citations
articleOpen accessSenior authorTraction force microscopy (TFM) is an important family of techniques used to measure and study the role of cellular traction forces (CTFs) associated with many biological processes. However, current standard TFM methods rely on imaging techniques that do not provide the experimental capabilities necessary to study CTFs within 3D collective and dynamic systems embedded within optically scattering media. Traction force optical coherence microscopy (TF-OCM) was developed to address these needs, but…
Scientific Reports · 2021-10-15 · 6 citations
articleOpen accessSenior authorSpatial resolution in conventional optical microscopy has traditionally been treated as a fixed parameter of the optical system. Here, we present an approach to enhance transverse resolution in beam-scanned optical coherence tomography (OCT) beyond its aberration-free resolution limit, without any modification to the optical system. Based on the theorem of invariance of information capacity, resolution-enhanced (RE)-OCT navigates the exchange of information between resolution and signal-to-noise…
Recent grants
Volumetric Traction Force Tomography of Collective Cell Migration Dynamics
NIH · $434k · 2016–2019
NIH · $1.7M · 2019–2024
THREE-DIMENSIONAL MECHANO-MICROSCOPY OF THE STEM CELL NICHE
NIH · $611k · 2018–2021
Frequent coauthors
- 74 shared
SA Boppart
Diagnostic Photonics (United States)
- 74 shared
KA Cradock
Carle Foundation Hospital
- 68 shared
Stephen A. Boppart
University of Illinois System
- 65 shared
PS Carney
Carle Foundation Hospital
- 65 shared
DT McCormick
University of Illinois Urbana-Champaign
- 49 shared
LK Jacobs
Diagnostic Photonics (United States)
- 49 shared
DA Darga
University of Illinois System
- 49 shared
Partha Ray
Education
- 2007
PhD, School of Electrical, Electronic and Computer Engineering
University of Western Australia
- 1997
Bachelor of Science (Hons), Chemical Physics
University of Western Australia
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