Shawn Pan
University of Chicago · Pharmacology
Active 2000–2023
About
Shawn Pan is an Assistant Professor of Anesthesia and Critical Care at the Biological Sciences Division of The University of Chicago. His research focuses on the metabolic regulation of cancer-associated fibroblasts, with significant contributions including the identification of NNMT as a master metabolic regulator through proteomics studies. His work has been published in reputable journals such as Nature, Cancer Discovery, and Oncotarget, highlighting his expertise in cancer metabolism and progression. Dr. Pan's research aims to deepen the understanding of metabolic pathways involved in cancer development and progression, contributing to the development of targeted therapies.
Research topics
- Internal medicine
- Biology
- Genetics
- Cancer research
- Medicine
- Gynecology
- Oncology
Selected publications
2023-04-03
supplementary-materialsOpen access<p>Single nucleotide variants and indels.</p>
2023-04-03
supplementary-materialsOpen access<p>Newick trees and cophenetic correlation coefficients.</p>
2023-04-03
supplementary-materialsOpen access<p>Copy number variation segments.</p>
2023
- Oncology
- Cancer research
- Medicine
<div>Abstract<p>Accumulating evidence has supported the fallopian tube rather than the ovary as the origin for high-grade serous ovarian cancer (HGSOC). To understand the relationship between putative precursor lesions and metastatic tumors, we performed whole-exome sequencing on specimens from eight HGSOC patient progression series consisting of serous tubal intraepithelial carcinomas (STIC), invasive fallopian tube lesions, invasive ovarian lesions, and omental metastases. Integration of copy number and somatic mutations revealed patient-specific patterns with similar mutational signatures and copy-number variation profiles across all anatomic sites, suggesting that genomic instability is an early event in HGSOC. Phylogenetic analyses supported STIC as precursor lesions in half of our patient cohort, but also identified STIC as metastases in 2 patients. <i>Ex vivo</i> assays revealed that HGSOC spheroids can implant in the fallopian tube epithelium and mimic STIC lesions. That STIC may represent metastases calls into question the assumption that STIC are always indicative of primary fallopian tube cancers.</p><p><b>Significance:</b> We find that the putative precursor lesions for HGSOC, STIC, possess most of the genomic aberrations present in advanced cancers. In addition, a proportion of STIC represent intraepithelial metastases to the fallopian tube rather than the origin of HGSOC. <i>Cancer Discov; 6(12); 1342–51. ©2016 AACR.</i></p><p><i>See related commentary by Swisher et al., p. 1309</i>.</p><p><i>This article is highlighted in the In This Issue feature, p. 1293</i></p></div>
2023-04-03
supplementary-materialsOpen access<p>Copy number variation segments.</p>
2023-04-03
supplementary-materialsOpen access<p>Exome sequencing quality metrics.</p>
2023-04-03
supplementary-materialsOpen access<p>Supplementary Figure S1. Sequencing of HGSOC reveals conserved mutational signatures and TP53 mutations. Supplementary Figure S2. Distribution of mutations and mutational signatures in HGSOC. Supplementary Figure S3. Genomic instability is a core feature of ovarian cancer that frequently involves DNA-damage repair genes. Supplementary Figure S4. Annotated dendrograms of HGSOC metastatic trajectories. Supplementary Figure S5. Ex vivo model of metastasis to the fallopian tube. Supplementary Figure S6. In vitro model of HGSOC-fallopian tube adhesion.</p>
2023-04-03
supplementary-materialsOpen access<p>Core amplifications and deletions.</p>
2023-04-03
supplementary-materialsOpen access<p>TP53 mutations in the patient cohort.</p>
2023-04-03
supplementary-materialsOpen access<p>Exome sequencing quality metrics.</p>
Frequent coauthors
- 10 shared
Ernst Lengyel
University of Chicago
- 9 shared
Matthias Mann
Max Planck Institute of Biochemistry
- 8 shared
Mark A. Eckert
University of Chicago
- 8 shared
Fabian Coscia
- 8 shared
Ricardo R. Lastra
- 7 shared
S. Diane Yamada
University of Chicago Medical Center
- 5 shared
Kyle M. Hernandez
Naval Health Research Center
- 5 shared
Samantha M. Tienda
University of Chicago
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