Seth Cohen

About

Professor Seth M. Cohen is the Principal Investigator of the Cohen laboratory at the University of California, San Diego. He is a graduate of Stanford University and the University of California, Berkeley. Following his graduate studies, he conducted postdoctoral research at the Massachusetts Institute of Technology (M.I.T.). Professor Cohen founded the Cohen laboratory in July 2001. The Cohen research group at UCSD is composed of a diverse team including undergraduate and graduate students, postdoctoral researchers, and visiting scholars with expertise spanning chemistry, biochemistry, and materials science. The group values diversity, collaboration, and fosters an inclusive environment that supports both individual and collective success.

Research topics

• Chemistry
• Nanotechnology
• Organic chemistry
• Computer Science
• Materials science
• Family medicine
• Physics
• Combinatorial chemistry
• Computational biology
• Biochemistry

Selected publications

• MOF-Polymer Hybrid Materials: From Simple Composites to Tailored Architectures

  Chemical Reviews · 2020 · 865 citations

  Senior authorCorresponding

  Metal-organic frameworks (MOFs) are inherently crystalline, brittle porous solids. Conversely, polymers are flexible, malleable, and processable solids that are used for a broad range of commonly used technologies. The stark differences between the nature of MOFs and polymers has motivated efforts to hybridize crystalline MOFs and flexible polymers to produce composites that retain the desired properties of these disparate materials. Importantly, studies have shown that MOFs can be used to influ…

  DOI

• Postsynthetic Modification: An Enabling Technology for the Advancement of Metal–Organic Frameworks

  ACS Central Science · 2020 · 523 citations

  Senior authorCorresponding

  Metal-organic frameworks (MOFs) are a class of porous materials with immense chemical tunability derived from their organic and inorganic building blocks. Presynthetic approaches have been used to construct tailor-made MOFs, but with a rather restricted functional group scope limited by the typical MOF solvothermal synthesis conditions. Postsynthetic modification (PSM) of MOFs has matured into an alternative strategy to broaden the functional group scope of MOFs. PSM has many incarnations, but t…

  DOI

• 25 Years of Reticular Chemistry

  Angewandte Chemie International Edition · 2021 · 404 citations

  At its core, reticular chemistry has translated the precision and expertise of organic and inorganic synthesis to the solid state. While initial excitement over metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) was undoubtedly fueled by their unprecedented porosity and surface areas, the most profound scientific innovation of the field has been the elaboration of design strategies for the synthesis of extended crystalline solids through strong directional bonds. In this cont…

  DOI

• Evaluation of a National Quality Improvement Collaborative for Improving Cancer Screening

  JAMA Network Open · 2022 · 27 citations

  Importance: Cancer screening deficits during the first year of the COVID-19 pandemic were found to persist into 2021. Cancer-related deaths over the next decade are projected to increase if these deficits are not addressed. Objective: To assess whether participation in a nationwide quality improvement (QI) collaborative, Return-to-Screening, was associated with restoration of cancer screening. Design, Setting, and Participants: Accredited cancer programs electively enrolled in this QI study. Pro…

  PublisherOA PDFDOI

• Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A

  Journal of Medicinal Chemistry · 2020 · 23 citations

  evaluation against the C165S mutant. Finally, a third-generation inhibitor was shown to have good cellular activity and low toxicity. In addition to our findings, an alternative method of modeling time-dependent inhibition that simplifies assay setup and allows comparison of inhibition models is discussed.

  DOI

Recent grants

• NIH Grant R03AI070651

  NIH · $153k · 2010

• Insight and Optimization of Metalloprotein Inhibitors

  NIH · $2.2M · 2011–2020

• Metal-binding Isosteres for Influenza Endonuclease Inhibitors and Beyond

  NIH · $1.8M · 2020–2026

Frequent coauthors

• Mark Kalaj

  97 shared

• D.T. Puerta

  73 shared

• Johannes Karges

  Ruhr University Bochum

  68 shared

• Benjamin L. Dick

  University of California, San Diego

  58 shared

• Hyeonglim Seo

  53 shared

• J. Andrew McCammon

  University of California, San Diego

  50 shared

• S.R. Halper

  The Aerospace Corporation

  50 shared

• Kenneth N. Raymond

  49 shared

Labs

• Cohen Research GroupPI

  Our team consists of a diverse group of undergraduate students, graduate students, postdoctoral researchers, and often visiting scholars that have a rich expertise in chemistry, biochemistry, and materials science.

Education

• B.S., Chemistry and Political Science

  Stanford University

• Ph.D.

  University of California, Berkeley

• Other

  Massachusetts Institute of Technology

Awards & honors

• NSF CAREER award
• ACS Cope Scholar Award
• 2004 Cottrell Scholar
• 2017 TREE
• 2022 IMPACT awards from RCSA

Similar researchers at University of California, San Diego

• J. Silvio Gutkindh-163
• Eduard Arzth-110
• Vicki Grassianh-102