Seema K. Shah
· Associate Professor of Law (Courtesy)Northwestern University · Pritzker School of Law
Active 1967–2026
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About
Seema K. Shah is an Associate Professor of Law (Courtesy) at Northwestern Pritzker School of Law. Her academic focus includes health law, as indicated by her course offerings in this area. She is part of the faculty involved in the Law, Business, and Economics Center and contributes to the academic community through her research and teaching. Her role involves engaging with students and the broader legal community at Northwestern Law, supporting the school's mission to provide comprehensive legal education and research.
Research topics
- Medicine
- Internal medicine
- Cardiology
- Computer Science
- Demography
- Endocrinology
- Pathology
- Machine Learning
- Artificial Intelligence
- Intensive care medicine
Selected publications
Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction
New England Journal of Medicine · 2022 · 2546 citations
BACKGROUND: Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure and cardiovascular death among patients with chronic heart failure and a left ventricular ejection fraction of 40% or less. Whether SGLT2 inhibitors are effective in patients with a higher left ventricular ejection fraction remains less certain. METHODS: We randomly assigned 6263 patients with heart failure and a left ventricular ejection fraction of more than 40% to receive dapagli…
The Lancet · 2022 · 875 citations
BACKGROUND: SGLT2 inhibitors are strongly recommended in guidelines to treat patients with heart failure with reduced ejection fraction, but their clinical benefits at higher ejection fractions are less well established. Two large-scale trials, DELIVER and EMPEROR-Preserved, in heart failure with mildly reduced or preserved ejection fraction have been done, providing power to examine therapeutic effects on cardiovascular mortality and in patient subgroups when combined with the earlier trials in…
Research Priorities for Heart Failure With Preserved Ejection Fraction
Circulation · 2020 · 401 citations
1st authorCorrespondingHeart failure with preserved ejection fraction (HFpEF), a major public health problem that is rising in prevalence, is associated with high morbidity and mortality and is considered to be the greatest unmet need in cardiovascular medicine today because of a general lack of effective treatments. To address this challenging syndrome, the National Heart, Lung, and Blood Institute convened a working group made up of experts in HFpEF and novel research methodologies to discuss research gaps and to pr…
JAMA · 2020 · 270 citations
Importance: Patients with heart failure and preserved ejection fraction (HFpEF) are at high risk of mortality, hospitalizations, and reduced functional capacity and quality of life. Objective: To assess the efficacy of the oral soluble guanylate cyclase stimulator vericiguat on the physical limitation score (PLS) of the Kansas City Cardiomyopathy Questionnaire (KCCQ). Design, Setting, and Participants: Phase 2b randomized, double-blind, placebo-controlled, multicenter trial of 789 patients with…
Circulation · 2020 · 259 citations
Senior authorCorrespondingBACKGROUND: A systemic proinflammatory state has been hypothesized to mediate the association between comorbidities and abnormal cardiac structure/function in heart failure with preserved ejection fraction (HFpEF). We conducted a proteomic analysis to investigate this paradigm. METHODS: In 228 patients with HFpEF from the multicenter PROMIS-HFpEF study (Prevalence of Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction), 248 unique circulating proteins were quantified by a…
Recent grants
Machine learning for the automated identification and tracking of rare myocardial diseases
NIH · $2.8M · 2018–2024
NIH · $6.5M · 2021
NIH · $33.7M · 2021–2026
Frequent coauthors
- 567 shared
Scott D. Solomon
Harvard University
- 421 shared
Brian Claggett
Brigham and Women's Hospital
- 401 shared
Bertram Pitt
Northwestern University
- 373 shared
Carolyn S.P. Lam
Duke-NUS Medical School
- 370 shared
Inder S. Anand
University of Minnesota
- 348 shared
Nancy K. Sweitzer
- 324 shared
Marc A. Pfeffer
Harvard University
- 319 shared
Amil M. Shah
Labs
Northwestern Pritzker School of Law Faculty & ResearchPI
Awards & honors
- Teaching Awards
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