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Sean Brady

Sean Brady

· Tri-Institutional Associate Profressor

Cornell University · Microbiology and Immunology

Active 1987–2026

h-index72
Citations16.3k
Papers20741 last 5y
Funding$141.6M1 active

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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Research topics

  • Biology
  • Computational biology
  • Chemistry
  • Genetics
  • Biochemistry

Selected publications

  • A naturally inspired antibiotic to target multidrug-resistant pathogens

    Nature · 2022-01-05 · 228 citations

    articleOpen accessSenior author
    PublisherOA PDFDOI

  • Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistance

    Science · 2022-05-26 · 120 citations

    articleOpen accessSenior authorCorresponding

    Emerging resistance to currently used antibiotics is a global public health crisis. Because most of the biosynthetic capacity within the bacterial kingdom has remained silent in previous antibiotic discovery efforts, uncharacterized biosynthetic gene clusters found in bacterial genome–sequencing studies remain an appealing source of antibiotics with distinctive modes of action. Here, we report the discovery of a naturally inspired lipopeptide antibiotic called cilagicin, which we chemically synt…

    PublisherOA PDFDOI

  • Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action

    Journal of the American Chemical Society · 2020-07-22 · 59 citations

    articleOpen accessSenior authorCorresponding

    Bacterial natural products have inspired the development of numerous antibiotics in use today. As resistance to existing antibiotics has become more prevalent, new antibiotic lead structures and activities are desperately needed. An increasing number of natural product biosynthetic gene clusters, to which no known molecules can be assigned, are found in genome and metagenome sequencing data. Here we access structural information encoded in this underexploited resource using a synthetic-bioinform…

    PublisherOA PDFDOI

Recent grants

Frequent coauthors

  • Melinda A. Ternei

    Rockefeller University

    51 shared

  • Jon Clardy

    Harvard University

    47 shared

  • Hahk‐Soo Kang

    Konkuk University

    29 shared

  • Boojala Vijay B. Reddy

    Acharya N. G. Ranga Agricultural University

    24 shared

  • Zachary Charlop–Powers

    Ginkgo BioWorks (United States)

    24 shared

  • Zhiyang Feng

    23 shared

  • Fang‐Yuan Chang

    National Central University

    22 shared

  • Nicolas Biais

    City University of New York

    19 shared

Labs

  • Microbiology and ImmunologyPI

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