A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves

Nature Biomedical Engineering · 2022 · 224 citations

• Medicine
• Biomedical engineering
• Surgery

Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerves that are difficult to reach via traditional surgeries. The device can be delivered through a percutaneous catheter and leverages magnetoelectric materials to receive data and power through tissue via a digitally programmable 1 mm × 0.8 mm system-on-a-chip. Implantation of the device directly on top of the sciatic nerve in rats and near a femoral artery in pigs (with a stimulation lead introduced into a blood vessel through a catheter) allowed for wireless stimulation of the animals' sciatic and femoral nerves. Minimally invasive magnetoelectric implants may allow for the stimulation of nerves without the need for open surgery or the implantation of battery-powered pulse generators.

Electric Vehicle Charging Infrastructure: From Grid to Battery

IEEE Industrial Electronics Magazine · 2021 · 273 citations

• Computer Science
• Business
• Environmental economics

Electrification has been a key component of technological progress and economic development since the industrial revolution. It has improved living conditions, spurred innovation, and increased efficiency across all sectors of our economy and all aspects of our lives. During the coming decades, electrification is expected to reach further and deeper into the transportation, building, and industry sectors, mainly motivated by the energy transition to a zero-carbonemission-based economy to mitigate climate change.