Sander Kersten

About

Sander Kersten is associated with the Bronfenbrenner Center for Translational Research at Cornell University. The center assists faculty in developing translational research projects, providing support such as proposal preparation, training, technical support, and facilitating collaborative relationships. The center also offers workshops, summer institutes, and talks on current research topics related to translational research. While specific details about Professor Kersten's individual research focus or background are not provided in the page text, his affiliation with the BCTR indicates involvement in research that aims to translate scientific findings into practical applications, supporting faculty in their research endeavors.

Research topics

• Biology
• Chemistry
• Cell biology
• Medicine
• Biochemistry
• Internal medicine
• Bioinformatics
• Endocrinology
• Cardiology

Selected publications

• Mechanisms of hepatic fatty acid oxidation and ketogenesis during fasting

  Trends in Endocrinology and Metabolism · 2023-11-06 · 76 citations

  reviewOpen accessSenior authorCorresponding
  PublisherOA PDFDOI

• Target Populations for Novel Triglyceride-Lowering Therapies

  Journal of the American College of Cardiology · 2025-05-01 · 42 citations

  review
  PublisherDOI

• Drug-target Mendelian randomization analysis supports lowering plasma ANGPTL3, ANGPTL4, and APOC3 levels as strategies for reducing cardiovascular disease risk

  European Heart Journal Open · 2024-04-26 · 35 citations

  articleOpen accessSenior author

  Aims: APOC3, ANGPTL3, and ANGPTL4 are circulating proteins that are actively pursued as pharmacological targets to treat dyslipidaemia and reduce the risk of atherosclerotic cardiovascular disease. Here, we used human genetic data to compare the predicted therapeutic and adverse effects of APOC3, ANGPTL3, and ANGPTL4 inactivation. Methods and results: We conducted drug-target Mendelian randomization analyses using variants in proximity to the genes associated with circulating protein levels to c…

  PublisherOA PDFDOI

• Regulation of Adipose Tissue Metabolism During Fasting

  Annual Review of Nutrition · 2025-05-06 · 6 citations

  reviewOpen accessSenior author

  There is widespread interest in fasting as a therapeutic or preventive regimen for improving health. This review provides an overview of the impact of fasting on adipose tissue metabolism, with special attention to sexually dimorphic regulation. During fasting, the storage of triacylglycerols in adipose tissue is inhibited via suppression of the extracellular lipolytic enzyme lipoprotein lipase. By contrast, the breakdown of stored triacylglycerols and subsequent release of fatty acids and glyce…

  PublisherDOI

• Characterization of sexual dimorphism in ANGPTL4 levels and function

  Journal of Lipid Research · 2024-02-29 · 6 citations

  articleOpen accessSenior authorCorresponding

  ANGPTL4 is an attractive pharmacological target for lowering plasma triglycerides and cardiovascular risk. Since most preclinical studies on ANGPTL4 were performed in male mice, little is known about sexual dimorphism in ANGPTL4 regulation and function. Here, we aimed to study potential sexual dimorphism in ANGPTL4 mRNA and protein levels and ANGPTL4 function. Additionally, we performed exploratory studies on the function of ANGPTL4 in the liver during fasting using Angptl4-transgenic and Angptl…

  PublisherOA PDFDOI

Frequent coauthors

• Michael Müller

  University of East Anglia

  167 shared

• Rinke Stienstra

  Radboud University Nijmegen

  115 shared

• Patrick C.N. Rensen

  67 shared

• Laeticia Lichtenstein

  University of Leeds

  60 shared

• Mark V. Boekschoten

  58 shared

• Nguan Soon Tan

  57 shared

• Guido J. E. J. Hooiveld

  Wageningen University & Research

  54 shared

• Anastasia Georgiadi

  Heinrich Heine University Düsseldorf

  54 shared

Education

• M.S., Human Nutrition

  Wageningen University

  1993

• Ph.D., Nutritional Biochemistry

  Cornell University

  1997

Similar researchers at Cornell University

• Robert Sternbergh-168
• Savita Sastryh-95
• Jenna Lih-85