New Method for Estimating Additive Blooming on the Surface of Vulcanised Rubbers

International Journal of Manufacturing Research · 2025-01-01

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SUSTAINABLE SOLUTIONS FOR INDUSTRIAL WASTEWATER MANAGEMENT USING PERMEABLE CONCRETE AND WATER REUSE FOR FLEET WASHING WITHIN THE FRAMEWORK OF THE CIRCULAR ECONOMY: CASE OF THE COMPANY CONCRETOS DE SINCELEJO

2025-07-07

One of the main environmental problems in Sincelejo (Sucre) is the inadequate disposal of industrial wastewater, much of which is discharged untreated into the urban drainage system, affecting surface and groundwater bodies. This research proposes a treatment system based on permeable concrete, designed with local materials, allowing for physical filtration of water and its subsequent reuse in activities such as fleet washing (vehicles, machinery, and equipment). Industries with a high environmental impact were identified to implement a low-cost, efficient, and sustainable solution aligned with the principles of the circular economy. The intervention at a concrete plant and a car wash company yielded positive results, demonstrating measurable environmental and economic benefits

Implementación exitosa de lean manufacturing y economía circular: lo que toda empresa debe considerar

Multidisciplinas de la Ingeniería · 2025-11-09

En este estudio se desarrolló en una investigación documental, descriptiva y de campo, aplicando encuestas diseñadas a partir de los factores críticos identificados en la literatura para la implementación de Lean Manufacturing y Economía Circular. La muestra incluyó 40 empresas localizadas en cuatro parques industriales del estado de Querétaro, parte de los 49 existentes en municipios como El Marqués, Querétaro, Colón, Corregidora, San Juan del Río y Pedro Escobedo, pertenecientes a sectores clave como automotriz, plástico, alimentario, agrícola, entre otros. Los hallazgos evidencian un marcado interés empresarial en incorporar estas metodologías y transitar hacia modelos operativos sostenibles. Sin embargo, persisten barreras relevantes asociadas con la cultura organizacional, la resistencia al cambio y las limitaciones en programas de formación. La integración de Lean Manufacturing y Economía Circular se perfila como una estrategia esencial para fortalecer la competitividad, optimizar procesos y reducir los impactos ambientales en la región, aportando un marco de referencia sólido para la gestión industrial con más de dos décadas de experiencia aplicada.

Supplementary Figure S3 from Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies

2024-02-22

<p>Rituximab dose selection based on macrophage phagocytosis in CD20-positive NHL cell lines. Data showed that a rituximab dose of 0.1 nM induced maximal phagocytosis in OCI-Ly3 cells.</p>

Supplementary Table S5 from Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies

2024-02-22

<p>Binding coverage of BMS-986351 across the six major SIRPα haplotypes</p>

Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies

Cancer Research Communications · 2024 · 9 citations

• Cancer research
• Biology
• Immunology

In normal cells, binding of the transmembrane protein CD47 to signal regulatory protein-α (SIRPα) on macrophages induces an antiphagocytic signal. Tumor cells hijack this pathway and overexpress CD47 to evade immune destruction. Macrophage antitumor activity can be restored by simultaneously blocking the CD47-SIRPα signaling axis and inducing a prophagocytic signal via tumor-opsonizing antibodies. We identified a novel, fully human mAb (BMS-986351) that binds SIRPα with high affinity. BMS-986351 demonstrated broad binding coverage across SIRPα polymorphisms and potently blocked CD47-SIRPα binding at the CD47 binding site in a dose-dependent manner. In vitro, BMS-986351 increased phagocytic activity against cell lines from solid tumors and hematologic malignancies, and this effect was markedly enhanced when BMS-986351 was combined with the opsonizing antibodies cetuximab and rituximab. A phase I dose-escalation/-expansion study of BMS-986351 for the treatment of advanced solid and hematologic malignancies is underway (NCT03783403). SIGNIFICANCE: Increasing the phagocytotic capabilities of tumor-associated macrophages by modulating macrophage-tumor cell surface signaling via the CD47-SIRPα axis is a novel strategy. Molecules targeting CD47 have potential but its ubiquitous expression necessitates higher therapeutic doses to overcome potential antigen sink effects. The restricted expression pattern of SIRPα may limit toxicities and lower doses of the SIRPα antibody BMS-986351 may overcome target mediated drug disposition while maintaining the desired pharmacology.

Supplementary Table S6 from Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies

2024-02-22

<p>Pearson correlation coefficient (cc) of SIRPA expression vs each macrophage-related gene in each of the separate TCGA cohorts, sorted high to low based on the mean of the correlation coefficients</p>

Supplementary Methods from Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies

2024-02-22

<p>Preparation of BMS-986351</p>

Supplementary Table S1 from Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies

2024-02-22

<p>Abundance of the most prevalent CD47–SIRPα binding interface haplotypes</p>