Robert Landick
· Professor of BiochemistryUniversity of Wisconsin-Madison · Bacteriology
Active 1975–2027
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About
Robert Landick is a Professor of Biochemistry at the University of Wisconsin-Madison, within the Department of Bacteriology. He is based in the Microbial Sciences Building located at 1550 Linden Dr., Madison, WI 53706. As a faculty member, he is involved in research and teaching activities related to biochemistry and microbiology. His contact information includes a phone number (608) 265-8475 and an email address landick@bact.wisc.edu. Further details about his research focus, background, and key contributions are not provided on the page.
Research topics
- Biology
- Genetics
- Cell biology
- Computer Science
- Molecular biology
- Biochemistry
- Computational biology
- Chemistry
- Virology
Selected publications
Structural basis for backtracking by the SARS-CoV-2 replication–transcription complex
Proceedings of the National Academy of Sciences · 2021 · 121 citations
Backtracking, the reverse motion of the transcriptase enzyme on the nucleic acid template, is a universal regulatory feature of transcription in cellular organisms but its role in viruses is not established. Here we present evidence that backtracking extends into the viral realm, where backtracking by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) may aid viral transcription and replication. Structures of SARS-CoV-2 RdRp bound to the essentia…
Transcriptional Pausing as a Mediator of Bacterial Gene Regulation
Annual Review of Microbiology · 2021 · 66 citations
1st authorCorrespondingCellular life depends on transcription of DNA by RNA polymerase to express genetic information. RNA polymerase has evolved not just to read information from DNA and write it to RNA but also to sense and process information from the cellular and extracellular environments. Much of this information processing occurs during transcript elongation, when transcriptional pausing enables regulatory decisions. Transcriptional pauses halt RNA polymerase in response to DNA and RNA sequences and structures…
Crabtree/Warburg-like aerobic xylose fermentation by engineered Saccharomyces cerevisiae
Metabolic Engineering · 2021 · 65 citations
Bottlenecks in the efficient conversion of xylose into cost-effective biofuels have limited the widespread use of plant lignocellulose as a renewable feedstock. The yeast Saccharomyces cerevisiae ferments glucose into ethanol with such high metabolic flux that it ferments high concentrations of glucose aerobically, a trait called the Crabtree/Warburg Effect. In contrast to glucose, most engineered S. cerevisiae strains do not ferment xylose at economically viable rates and yields, and they requi…
Alternative transcription cycle for bacterial RNA polymerase
Nature Communications · 2020 · 44 citations
RNA polymerases (RNAPs) transcribe genes through a cycle of recruitment to promoter DNA, initiation, elongation, and termination. After termination, RNAP is thought to initiate the next round of transcription by detaching from DNA and rebinding a new promoter. Here we use single-molecule fluorescence microscopy to observe individual RNAP molecules after transcript release at a terminator. Following termination, RNAP almost always remains bound to DNA and sometimes exhibits one-dimensional slidin…
Proceedings of the National Academy of Sciences · 2020 · 25 citations
CarD levels when cells enter stationary phase, suggesting that reduced activation by CarD may contribute to inhibition of rRNA transcription when cells enter stationary phase, the stage of growth when bacterial ribosome synthesis declines.
Recent grants
NIH · $25k
NIH · $5.5M · 2011
NIH · $775k · 2011
Frequent coauthors
- 77 shared
Rachel A. Mooney
- 76 shared
Yaoping Zhang
Southeast University
- 72 shared
Joshua J. Coon
Morgridge Institute for Research
- 69 shared
Trey K. Sato
Great Lakes Bioenergy Research Center
- 50 shared
Seth A. Darst
- 39 shared
Jessica M. Vera
University of Wisconsin–Madison
- 38 shared
Alexander S. Hebert
University of Wisconsin–Madison
- 34 shared
Patricia J. Kiley
Labs
Education
- 1990
Ph.D., Microbiology
University of Wisconsin-Madison
- 1986
M.S., Microbiology
University of Wisconsin-Madison
- 1984
B.S., Microbiology
University of Wisconsin-Madison
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