Robert Damoiseaux
· ProfessorUniversity of California, Los Angeles · Nuclear Medicine & Theranostics
Active 2001–2026
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About
Robert Damoiseaux, Ph.D., is a High Throughput Screening (HTS) expert and a professor in the Department of Molecular and Medical Pharmacology at the University of California, Los Angeles (UCLA). He also holds a position as Professor of Bioengineering in the Samueli School of Engineering at UCLA. His research interests focus on the development of novel technologies for high throughput screening and drug discovery and development. Dr. Damoiseaux directs the Molecular Screening Shared Resource (MSSR), a cutting-edge facility involved in research projects with UCLA, Caltech, and the biotech and pharmaceutical industries. He received his Ph.D. in Bio-organic Chemistry from the University of Lausanne, Switzerland, where he studied under Dr. Kai Johnsson. Prior to his current roles, he was in charge of developing next-generation assay platforms for proteases at the Institute for Functional Genomics (GNF, Novartis). Dr. Damoiseaux has authored over 100 manuscripts and patents related to high throughput screening and synthesis. He is recognized as an expert author in Wiley's Development of Therapeutic Agents Handbook and serves as an editor for Springer's Current Protocols in Molecular Biology. His expertise in high-throughput screening and novel technologies has made him a sought-after collaborator and consultant in both academia and industry.
Research topics
- Biology
- Cell biology
- Biochemistry
- Virology
- Immunology
- Genetics
- Computational biology
- Molecular biology
- Cancer research
- Chemistry
Selected publications
Nature Communications · 2021 · 151 citations
Viruses hijack host cell metabolism to acquire the building blocks required for replication. Understanding how SARS-CoV-2 alters host cell metabolism may lead to potential treatments for COVID-19. Here we profile metabolic changes conferred by SARS-CoV-2 infection in kidney epithelial cells and lung air-liquid interface (ALI) cultures, and show that SARS-CoV-2 infection increases glucose carbon entry into the TCA cycle via increased pyruvate carboxylase expression. SARS-CoV-2 also reduces oxidat…
Science Translational Medicine · 2020 · 129 citations
tumors. BO-112 activated double-stranded RNA (dsRNA) sensing (via protein kinase R and Toll-like receptor 3) and induced MHC I expression via nuclear factor κB, independent of both IFN signaling and NLRC5. In summary, we demonstrated that in the absence of tumor IFN signaling, MHC I expression is essential and sufficient for the efficacy of ACT. For tumors lacking MHC I expression due to deficient IFN signaling, activation of dsRNA sensors by BO-112 affords an alternative approach to restore the…
Cell Reports · 2021 · 119 citations
SARS-CoV-2 has currently precipitated the COVID-19 global health crisis. We developed a medium-throughput drug-screening system and identified a small-molecule library of 34 of 430 protein kinase inhibitors that were capable of inhibiting the SARS-CoV-2 cytopathic effect in human epithelial cells. These drug inhibitors are in various stages of clinical trials. We detected key proteins involved in cellular signaling pathways mTOR-PI3K-AKT, ABL-BCR/MAPK, and DNA-damage response that are critical f…
Suspendable Hydrogel Nanovials for Massively Parallel Single-Cell Functional Analysis and Sorting
ACS Nano · 2022 · 94 citations
Techniques to analyze and sort single cells based on functional outputs, such as secreted products, have the potential to transform our understanding of cellular biology as well as accelerate the development of next-generation cell and antibody therapies. However, secreted molecules rapidly diffuse away from cells, and analysis of these products requires specialized equipment and expertise to compartmentalize individual cells and capture their secretions. Herein, we describe methods to fabricate…
Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair
Journal of Clinical Investigation · 2021 · 40 citations
Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair. Using a murine model of ischemic cardiac injury, we demonstrate that cardiomyocytes play a pivotal role in heart repair by regulating nucleotide metabolism and fates of nonmyocytes. Cardiac injury induced the expression of the ectonucleotidase ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which hydrolyzes extracellular ATP to…
Recent grants
Cancer Molecular Imaging, Nanotechnology, and Theranostics (CMINT)
NIH · $65.6M · 1996–2030
NIH · $1.1M · 2015–2019
Frequent coauthors
- 110 shared
Begoña Díaz
- 108 shared
Delphine J. Lee
- 106 shared
Sofia Geroyska
UCLA Medical Center
- 106 shared
Isabel Mejia
- 104 shared
Elizabeta Nemeth
- 103 shared
David B. Shackelford
- 102 shared
Alfred A. Chan
- 102 shared
Marian Navarrete
UCLA Medical Center
Education
- 2001
PhD, Chemistry
Universite de Lausanne
- 1995
MS, Chemistry
Ruhr-Universität Bochum
Awards & honors
- Founder, EnspireBio, Inc. (2018)
- Founder, Forcyte Biotechnologies, Inc. (2017)
- Director, Molecular Screening Shared Resource, UCLA (2015 -…
- Drug and Device Development UCLA Campus Lead For the UC Biom…
- Fellow, Novartis Institute for Functional Genomics (2003 - 2…
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