Richard Wang

Precision Oncology: Current Landscape, Emerging Trends, Challenges, and Future Perspectives

Preprints.org · 2025-10-14 · 2 citations

Precision oncology is broadly defined as cancer prevention, diagnosis, and treatment specifically tailored to the patient based on his/her genetics and molecular profile. In simple terms, the goal of precision medicine is to deliver the right cancer treatment to the right patient, at the right dose, at the right time. Precision oncology is the most studied and widely applied subarea of precision medicine. Now, precision oncology has expanded to include modern technology (big data, single-cell sp…

A Rare Case of Osteosarcoma in an Individual with the Recurrent n.64_65insT Variant in the <i>RNU</i><i>4-2</i> Gene

Case Reports in Clinical Medicine · 2025-01-01

Background: Variants in the RNU4-2 gene are one of the most common autosomal causes of Neurodevelopmental Disorders (NDD). Despite the increased recognition of their clinical impact, associated malignancies have not been previously reported. Case Findings: We present a male patient with the most common RNU4-2 gene variant, n.64_65insT. At age 21, he was diagnosed with Osteosarcoma (OS), a condition not previously reported in affected individuals, and died 5 months later. Clinical Implication: Th…