About

Dr. Moellering is a Professor of Chemistry at the University of Chicago. He obtained Bachelor's degrees in Chemistry and Biochemistry & Molecular Biophysics from the University of Arizona. He then earned a Ph.D. in Chemistry at Harvard University as an American Association for Cancer Research Centennial Fellow, followed by postdoctoral training as a Damon Runyon Postdoctoral Fellow at The Scripps Research Institute. Dr. Moellering started his independent program at UChicago in 2015, where his laboratory is focused on developing novel chemical probes, proteomic technology platforms and therapeutic modalities to expose and exploit signaling pathways in cancer, inflammatory disorders and degenerative diseases like aging. Dr. Moellering’s independent program has garnered recognition with awards that include the Damon Runyon Dale F. Frey Award for Breakthrough Scientists, V Foundation V Scholar Award, American Cancer Society Research Scholar Award, NSF CAREER Award, Sloan Fellowship, and NIH Pathway to Independence and Director’s New Innovator Awards. He has served as scientific founder and advisor to several biotechnology companies and serves as a scientific advisor to several philanthropic disease foundations.

Research topics

• Biology
• Genetics
• Computational biology
• Internal medicine
• Cell biology
• Medicine
• Pathology
• Virology
• Cancer research
• Immunology

Selected publications

• siPROX interactome derived from AC1 proximity probe using HEK293T cells stably expressing SNAP-MYC and treated with JQ-1 (500 nM) or Vehicle for 0.5 and 2 h.

  Open MIND · 2026-01-01

  other1st authorCorresponding

• MassIVE MSV000100910 - siPROX Manuscript: HEK293T siPROX profiles using AC1_JQ1_acute-treatment

  2026-01-01

  datasetOpen access1st authorCorresponding
  OA PDFDOI

• MassIVE MSV000100907 - siPROX Manuscript: HEK293T siPROX profile using AC1 probe_no drug

  2026-01-01

  datasetOpen access1st authorCorresponding
  OA PDFDOI

• siPROX interactomes derived from AC1 and AC3 proximity probes using HEK293T cells stably expressing SNAP-MYC.

  Open MIND · 2026-01-01

  other1st authorCorresponding

• siPROX interactome derived from AC1 proximity probe using HEK293T cells stably expressing SNAP-MYC and treated with JQ1 (24 h, 500 nM).

  Open MIND · 2026-01-01

  other1st authorCorresponding

• MassIVE MSV000100911 - siPROX Manuscript: HEK293T siPROX profiles_MYC_VCL_LFQ

  2026-01-01

  datasetOpen access1st authorCorresponding
  OA PDFDOI

• MassIVE MSV000100901 - siPROX Manuscript: NCI-H1048 siPROX profiles using AC1 and AC3 with triple SILAC

  2026-01-01

  datasetOpen access1st authorCorresponding
  OA PDFDOI

• siPROX interactome derived from AC1 proximity probe using HEK293T cells stably expressing SNAP-MYC under basal conditions.

  Open MIND · 2026-01-01

  other1st authorCorresponding

• Whole proteome profiles of NCI-H1048 cells over-expressing SNAP-MYC treated with Vehicle, BRM1 (500 nM), and JQ1 (500 nM) for 24 h.

  Open MIND · 2026-01-01

  other1st authorCorresponding

• Quantitative chemoproteomics to study sites of methylglyoxal modification

  Open MIND · 2026-01-01

  other1st authorCorresponding

Recent grants

• CAREER: Reactivity-Driven Metabolic Signaling: A Feature not a Flaw in Metabolic Regulation

  NSF · $730k · 2019–2025

• Targeting Transcription with Synthetic Biologics

  NIH · $2.3M · 2017–2022

• NIH Grant R00CA175399

  NIH · $712k · 2018

• Direct Targeting of MYC in Cancer with Hyperstable Synthetic Transcriptional Repressors

  NIH · $756k · 2024–2029

• NIH Grant K99CA175399

  NIH · $89k · 2015

Frequent coauthors

• Jae Won Chang

  Chungnam National University

  54 shared

• John S. Coukos

  University of Chicago

  45 shared

• Lewis C. Cantley

  Dana-Farber Cancer Institute

  45 shared

• Benjamin D. Stein

  Cornell University

  42 shared

• Bryan Ngo

  Weill Cornell Medicine

  42 shared

• Miriam Sindelar

  Washington University in St. Louis

  42 shared

• David Wu

  University of Washington

  42 shared

• Harold Varmus

  Weill Cornell Medicine

  41 shared

Labs

• Moellering LabPI

Education

• B.S. in Chemistry; B.S. in Biochemistry and Molecular Biophysics

  University of Arizona

• A.M. in Chemistry and Chemical Biology

  Harvard University

• Ph.D. in Chemistry and Chemical Biology

  Harvard University

Awards & honors

• Susan G. Komen Career Catalyst Fellow 2021
• Sloan Research Fellow 2020
• National Science Foundation CAREER Award 2019
• American Cancer Society Research Scholar 2017
• NIH Director’s New Innovator Award 2017