
Raymond Dougherty, M.D.
· Clinical Professor, Department of Radiology, Chair, Emeritus Department of RadiologyVerifiedUniversity of California, Davis · Radiology
Active 1977–2024
Research topics
- Pathology
- Internal medicine
- Psychology
- Psychiatry
- Cardiology
- Medicine
Selected publications
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 2021 · 47 citations
1st authorCorresponding- Medicine
- Internal medicine
- Cardiology
INTRODUCTION: Cardiorespiratory fitness (CRF) may mitigate Alzheimer's disease (AD) progression. This study examined the longitudinal associations of CRF with brain atrophy and cognitive decline in a late-middle-aged cohort of adults at risk for AD. METHODS: One hundred ten cognitively unimpaired adults (66% female, mean age at baseline 64.2 ± 5.7 years) completed a baseline graded treadmill exercise test, two brain magnetic resonance imaging scans (over 4.67 ± 1.17 years), and two to three cognitive assessments (over 3.26 ± 1.02 years). Linear mixed effects models examined the longitudinal associations adjusted for covariates. RESULTS: = .426). Exploratory analyses suggested these effects may be stronger among apolipoprotein E ε4 carriers. DISCUSSION: CRF is a modifiable physiological attribute that may be targeted during the preclinical phase of AD in effort to delay disease progression, perhaps most effectively among those with genetic risk.
Frequent coauthors
- 50 shared
Ozioma C. Okonkwo
Geriatric Research Education and Clinical Center
- 34 shared
Sterling C. Johnson
Temple University
- 30 shared
Dane B. Cook
University of Wisconsin–Madison
- 26 shared
Jennifer A. Schrack
Johns Hopkins University
- 22 shared
Sanjay Asthana
Geriatric Research Education and Clinical Center
- 20 shared
Eleanor M. Simonsick
National Institutes of Health
- 20 shared
Catherine L. Gallagher
- 19 shared
Amal A. Wanigatunga
Johns Hopkins University
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