Rashid Bashir

About

Rashid Bashir is a member of the American Academy of Arts and Sciences, recognized in 2024. He is affiliated with the Grainger College of Engineering and is involved in multiple research units including Bioengineering, Mechanical Science and Engineering, Electrical and Computer Engineering, Materials Science and Engineering, and Materials Research Lab. His work is associated with the Coordinated Science Lab, Biomedical and Translational Sciences, the Beckman Institute for Advanced Science and Technology, the Carl R. Woese Institute for Genomic Biology, and the National Center for Supercomputing Applications (NCSA).

Research topics

• Computer Science
• Biology
• Materials science
• Nanotechnology
• Medicine
• Chemistry
• Virology
• Chromatography
• Optoelectronics
• Genetics

Selected publications

• Ultrasensitive detection of nucleic acids using deformed graphene channel field effect biosensors

  Nature Communications · 2020 · 416 citations

  Senior authorCorresponding

  Field-effect transistor (FET)-based biosensors allow label-free detection of biomolecules by measuring their intrinsic charges. The detection limit of these sensors is determined by the Debye screening of the charges from counter ions in solutions. Here, we use FETs with a deformed monolayer graphene channel for the detection of nucleic acids. These devices with even millimeter scale channels show an ultra-high sensitivity detection in buffer and human serum sample down to 600 zM and 20 aM, resp…

  DOI

• Rapid isothermal amplification and portable detection system for SARS-CoV-2

  Proceedings of the National Academy of Sciences · 2020 · 415 citations

  Senior authorCorresponding

  The COVID-19 pandemic provides an urgent example where a gap exists between availability of state-of-the-art diagnostics and current needs. As assay protocols and primer sequences become widely known, many laboratories perform diagnostic tests using methods such as RT-PCR or reverse transcription loop mediated isothermal amplification (RT-LAMP). Here, we report an RT-LAMP isothermal assay for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and demonstrate the…

  DOI

• COVID-19 Point-of-Care Diagnostics: Present and Future

  ACS Nano · 2021 · 181 citations

  Senior authorCorresponding

  Point-of-care (POC) detection technologies that enable decentralized, rapid, sensitive, low-cost diagnostics of COVID-19 infection are urgently needed around the world. With many technologies approved for commercialization in the past 10 months, the field of COVID-19 POC diagnostics is rapidly evolving. In this Perspective, we analyze the current state of POC technologies for the diagnosis and monitoring of COVID-19 infection and discuss future challenges in COVID-19 diagnostics. As the COVID-19…

  DOI

• Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

  Lab on a Chip · 2020 · 133 citations

  Rapid, sensitive and specific detection and reporting of infectious pathogens is important for patient management and epidemic surveillance. We demonstrated a point-of-care system integrated with a smartphone for detecting live virus from nasal swab media, using a panel of equine respiratory infectious diseases as a model system for corresponding human diseases such as COVID-19. Specific nucleic acid sequences of five pathogens were amplified by loop-mediated isothermal amplification on a microf…

  DOI

• Ultrasensitive Detection of Dopamine, IL‐6 and SARS‐CoV‐2 Proteins on Crumpled Graphene FET Biosensor

  Advanced Materials Technologies · 2021 · 98 citations

  Senior authorCorresponding

  Universal platforms for biomolecular analysis using label-free sensing modalities can address important diagnostic challenges. Electrical field effect-sensors are an important class of devices that can enable point-of-care sensing by probing the charge in the biological entities. Use of crumpled graphene for this application is especially promising. It is previously reported that the limit of detection (LoD) on electrical field effect-based sensors using DNA molecules on the crumpled graphene FE…

  DOI

Recent grants

• DNA Methylation Analysis Using Solid-State Nanopore Sensors - A Pathway to Early

  NIH · $355k · 2011–2012

• An Integrated Lab-on-a-Transistor for Biological Detection

  NSF · $300k · 2010–2014

• Integrated Nanowire Array Sensors for Biomolecular Detection

  NSF · $240k · 2006–2009

Frequent coauthors

• Enrique Valera

  University of Illinois Urbana-Champaign

  96 shared

• Ali Khademhosseini

  Terasaki Foundation

  91 shared

• Deirdre Meldrum

  Institute of Nanotechnology

  73 shared

• Kenji Sunagawa

  73 shared

• Claudio Cobelli

  University of Padua

  73 shared

• A. M. Russell

  Computational Intelligence and Information Systems Lab

  73 shared

• Henry Hess

  Columbia University

  73 shared

• B Wheeler

  IEEE Computer Society

  72 shared

Labs

• Neuroscience ProgramPI

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