Randee Lawrence
· Adjunct Associate ProfessorVerifiedColumbia University · Organization & Leadership
Active 1957–2025
About
Randee Lawrence is an Adjunct Associate Professor at Teachers College, Columbia University. She is affiliated with the Organization & Leadership and Adult Learning and Leadership departments. Her office is located at 201 Zankel on the Teachers College campus in New York City. Contact information includes a phone number at 212-678-3760. The biography does not provide additional details about her research focus, background, or key contributions.
Research topics
- Biochemistry
- Biology
- Demography
- Molecular biology
- Medicine
- Nursing
- Emergency medicine
- Medical emergency
- Psychiatry
Selected publications
Cambridge University Press eBooks · 2025-01-02
book-chapter1st authorCorrespondingEffectiveness Trials in Schizophrenia: Necessary. Sufficient?
Annals of Clinical Psychiatry · 2025-05-01
article1st authorCorrespondingBackground Clinical trials are criticized for excluding important clinical populations. Effectiveness trials propose to mitigate this, but whether they succeed has not been studied. We compared exclusion criteria in efficacy and effectiveness clinical trials and assessed their impact on eligibility in a clinical sample. Methods We used Qualitative Content Analysis to extract common exclusion criteria from recent trials, then assessed their frequencies among a one-month sample of adults in an emergency department with psychosis. Results Among 107 unique clinical trials, efficacy trials utilized 12.3 exclusion criteria categories on average, while effectiveness trials utilized 9.1. Efficacy trials were more likely to have exclusions for substance use, suicide risk, violence risk, and medical problems. In the clinical sample (N = 297), substance use, suicide risk, and violence risk had the greatest impact on eligibility, excluding 85.5% of patients. Other exclusion criteria also impact eligibility; trials that allow substance use, suicide risk, and violence risk would still likely exclude 81.8%. Conclusions Effectiveness trials do utilize fewer exclusion criteria than efficacy trials, but the difference is incremental and does not resolve generalizability problems. Even a few exclusion criteria can have a large impact on eligibility. Development of an evidence base for under-studied populations is needed.
2025-01-01
book-chapter1st authorCorrespondingAbstract In the course of its history, psychiatry has faced many challenges and controversies, including an ongoing search for biomarkers, a need for more effective treatments, difficulties in enabling access to care, questions surrounding the appropriateness of involuntary treatment, and ongoing stigma. These challenges are not unique to the present age. Each has historical precedent and exists in a historical context that has profoundly shaped how psychiatry has evolved over decades and sometimes over centuries. Understanding this historical context provides perspective on how these challenges developed into their current shape and offers hints of the future. This chapter provides a historical review of the field of psychiatry.
Ethics in placebo-controlled, acute treatment trials in schizophrenia: Two rival ethical frameworks
Schizophrenia Research · 2024-01-17
article1st authorCorrespondingSchizophrenia and Other Primary Psychotic Disorders
2024-01-01 · 1 citations
book-chapter1st authorCorrespondingJournal of Dual Diagnosis · 2024-07-16 · 1 citations
article1st authorCorrespondingClinical trials using typical exclusion criteria exclude nearly all emergency psychiatry patients with substance use problems.
Clinical Trials Studying Suicide Risk Reduction: Who is Excluded From Participation
Archives of Suicide Research · 2024-02-28 · 6 citations
article1st authorCorrespondingOBJECTIVE: The use of exclusion criteria in clinical trials can cause research participants to differ markedly from clinical populations, which negatively impacts generalizability of results. This study identifies and quantifies common and recurring exclusion criteria in clinical trials studying suicide risk reduction, and estimates their impact on eligibility among a clinical sample of adults in an emergency department with high suicide risk. METHOD: Recent trials were identified by searching PubMed (terms suicide, efficacy, effectiveness, limited to clinical trials in prior 5 years). Common exclusion criteria were identified using Qualitative Content Analysis. A retrospective chart review examined a one-month sample of all adults receiving psychiatric evaluation in a large urban academic emergency department. RESULTS: = 232), psychosis exclusions would exclude 53.0% of patients and substance use exclusions would exclude 67.2% of patients. Overall, 5.6% of emergency psychiatry patients would be eligible for clinical trials that use common exclusion criteria. CONCLUSIONS: Recent clinical trials studying suicide risk reduction have low generalizability to emergency psychiatry patients with high suicide risk. Trials enrolling persons with psychosis and substance use in particular are needed to improve generalizability to this clinical population.
Physical Assault in the Psychiatry Emergency Room
FOCUS The Journal of Lifelong Learning in Psychiatry · 2023-01-01 · 14 citations
articleOpen access1st authorCorrespondingPrevious studies of physical assaults in hospitals focused primarily on inpatient psychiatric units, leaving unanswered questions about the extent to which findings generalize to psychiatric emergency rooms. Assault incident reports and electronic medical records from one psychiatric emergency room and two inpatient psychiatric units were reviewed. Qualitative methods were used to identify precipitants. Quantitative methods were used to describe characteristics of each event, as well as demographic and symptom profiles associated with incidents. During the five-year study period, there were 60 incidents in the psychiatric emergency room and 124 incidents on the inpatient units. Precipitating factors, incident severity, means of assault, and interventions were similar in both settings. Among patients in the psychiatric emergency room, a diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder with manic symptoms (Adjusted Odds Ratio (AOR) 27.86) and presenting with thoughts to harm others (AOR 10.94) were associated with an increased likelihood of having an assault incident report. Similarities between assaults in the psychiatric emergency room and inpatient psychiatric units suggest that the broader literature from inpatient psychiatry can be generalized to the psychiatric emergency room setting, although some differences exist. Reprinted from J Am Acad Psychiatry Law 2020; 48:484–495, with permission from The American Academy of Psychiatry and the Law. Copyright © 2020
Patient Ineligibility as a Barrier to Participation in Clinical Trials
The American Journal of Bioethics · 2023-07-14 · 3 citations
letter1st authorCorrespondingClick to increase image sizeClick to decrease image sizeThis article refers to:Do Clinicians Have a Duty to Participate in Pragmatic Clinical Trials? Additional informationFundingThis work was funded by a gift from the Elizabeth Dollard Charitable Trust, to Columbia University.
Academic Psychiatry · 2023-04-04 · 2 citations
letter
Frequent coauthors
- 95 shared
Lisa B. Dixon
Columbia University
- 80 shared
Farr A. Curlin
Duke University
- 56 shared
John D. Yoon
University of Chicago
- 52 shared
Phoebe Friesen
McGill University
- 52 shared
Ragy R. Girgis
Columbia University
- 52 shared
Gary Brucato
- 51 shared
Paul S. Appelbaum
Columbia University
- 40 shared
Kenneth A. Rasinski
University of Illinois Chicago
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