Mentorship is associated with greater opportunity access, application confidence, and satisfaction among medical students pursuing dermatology

Journal of the American Academy of Dermatology · 2026-04-01

Racial and ethnic representation across acral lentiginous melanoma clinical trials

Research Square · 2025-11-28

0698 Examining the role of socioeconomic status on severity and outcomes in acral lentiginous melanoma

Journal of Investigative Dermatology · 2025-07-21

Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8+ T cells in disease

Cell Reports · 2025-06-17 · 5 citations

<h2>Summary</h2> Alopecia areata (AA) is an immune-mediated hair loss disorder characterized by the infiltration of immune cells, including clonally expanded CD8⁺ T cells into lesional skin. To explore the link between CD8⁺ T cell clonality and disease pathogenicity, we conducted single-cell RNA and T cell receptor (TCR) sequencing in the C3H/HeJ mouse model of AA. We analyzed T cells derived from skin and skin-draining lymph nodes to capture both the end-organ and the site of antigen priming and found striking hyper-expansion of T cell clones associated with disease onset. Using the hyperexpanded CD8⁺ TCR sequences, we generated TCR retrogenic mice engineered to express a single clonotypic T cell population, applied CRISPR-Cas9 to engineer these TCR sequences within CD8⁺ T cells, and performed depletion experiments to demonstrate that expanded CD8⁺ T cell clones are sufficient to initiate disease, establishing a causal relationship between CD8⁺ T cell clonality and pathogenicity in disease.

0799 Targeting UV-induced senescence in the skin microenvironment to prevent melanomagenesis

Journal of Investigative Dermatology · 2025-07-21

Tissue Procurement SOP - Discarded Human Skin v1

2024-03-05

The purpose of this procedure is to provide instructions to clinicians, researchers and support staff for the collection and handling of human skin tissue. Specifically, this document describes the proper sample storage, delivery, de-identification, processing, and data collection of discarded human skin from human subjects during tissue procurement for the project 5UG3CA275686.

840 Ultraviolet light-induced senescence modifies the skin microenvironment and promotes melanomagenesis in mice

Journal of Investigative Dermatology · 2024-07-19

10 X Visium Spatial Gene Expression - Fixed Frozen Tissue Processing with CytAssist v1

2024-03-18

Here we summarize the reccomendation released by 10X Genomics for processing fixed-frozen tissue sections while performing 10X Visium Spatial Gene Expression assay using the Visium CytAssist device. Please follow the link for the detailed official protocol on 10X Genomics website. https://cdn.10xgenomics.com/image/upload/v1680564483/support-documents/CG000662_Demonstrated_Protocol_VisiumCytAssist_FixedFrozen_H_E_RevA.pdf

525 Targeting CK2 activation as a therapeutic approach in acral melanoma

Journal of Investigative Dermatology · 2024-07-19

620 Elimination of therapy-induced senescent cells improves therapeutic outcomes in melanoma

Journal of Investigative Dermatology · 2024-07-19