About

Qing C Chen is a Professor in the Department of Pathology at Northwestern University Feinberg School of Medicine. His primary focus is on Hematopathology, which involves the study and diagnosis of diseases related to blood and lymphatic tissues. As a faculty member, he contributes to both research and education within the department, supporting the training of residents, fellows, and medical students. His work is integral to advancing understanding and diagnosis of hematologic diseases, although specific details of his research contributions are not provided on the page.

Research topics

• Medicine
• Immunology
• Cancer research
• Biology
• Pathology
• Gastroenterology
• Internal medicine
• Genetics

Selected publications

• Differentiating reactive and neoplastic gamma‐delta (γδ) T‐cell expansions in the peripheral blood and bone marrow

  Cytometry Part B Clinical Cytometry · 2024 · 1 citations

  • Medicine
  • Pathology
  • Internal medicine

  The clinical and immunophenotypic attributes of reactive γδ T-cell expansions are less well characterized than their malignant counterparts, which can pose diagnostic challenges. This study aims to investigate the characteristics and long-term clinical outcomes of reactive γδ T-cell expansions. A retrospective review was performed to identify patients with expanded γδ T-cell population (>15% of T-cells) by flow cytometry in peripheral blood and/or bone marrow specimens over a 17-year period. The cases were divided into reactive and malignant categories and their clinical and immunophenotypic findings were compared. Clinical follow-up was performed. 97 patients were identified including 19 malignant and 78 reactive cases with a variety of underlying conditions. The median absolute γδ T-cell count and median percentage of γδ T-cells per total T-cells were significantly lower in reactive vs. malignant cases (p = 0.0001 and p < 0.00001, respectively). Reactive cases showed more frequent brighter surface CD3 expression (87.1% vs. 42.1%; p < 0.0001), no discrete loss of CD7 (0% vs. 36.9%; p < 0.0001), less frequent lack of CD5 (25.7% vs. 42.4%; p < 0.0001), and no homogeneous CD56 expression (0% vs. 31.6%; p > 0.0001) as compared with malignant cases. Upon long-term follow-up, none of the reactive cases showed clinical evidence of malignant evolution. Reactive expansions of γδ T-cells can be seen in a variety of conditions including hematologic neoplasms, autoimmune and post-transplant states, and infections. Such cases have significantly lower γδ T-cell counts and percentages and no discrete loss of CD7. Lack of CD5 on its own is not an indication of immunophenotypic aberrancy in γδ T-cells. Upon long-term clinical follow-up, such reactive expansions show no evidence of evolution to γδ T-cell malignancies.

  DOI

• CSF3R mutated myeloid neoplasms: Beyond chronic neutrophilic leukemia

  Human Pathology · 2024 · 8 citations

  Senior authorCorresponding
  • Cancer research
  • Medicine
  • Immunology
  DOI

• Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection

  JAMA · 2023 · 831 citations

  • Medicine
  • Virology
  • Pathology

  Importance: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals. Objective: To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections. Design, Setting, and Participants: Prospective observational cohort study of adults with and without SARS-CoV-2 infection at 85 enrolling sites (hospitals, health centers, community organizations) located in 33 states plus Washington, DC, and Puerto Rico. Participants who were enrolled in the RECOVER adult cohort before April 10, 2023, completed a symptom survey 6 months or more after acute symptom onset or test date. Selection included population-based, volunteer, and convenience sampling. Exposure: SARS-CoV-2 infection. Main Outcomes and Measures: PASC and 44 participant-reported symptoms (with severity thresholds). Results: A total of 9764 participants (89% SARS-CoV-2 infected; 71% female; 16% Hispanic/Latino; 15% non-Hispanic Black; median age, 47 years [IQR, 35-60]) met selection criteria. Adjusted odds ratios were 1.5 or greater (infected vs uninfected participants) for 37 symptoms. Symptoms contributing to PASC score included postexertional malaise, fatigue, brain fog, dizziness, gastrointestinal symptoms, palpitations, changes in sexual desire or capacity, loss of or change in smell or taste, thirst, chronic cough, chest pain, and abnormal movements. Among 2231 participants first infected on or after December 1, 2021, and enrolled within 30 days of infection, 224 (10% [95% CI, 8.8%-11%]) were PASC positive at 6 months. Conclusions and Relevance: A definition of PASC was developed based on symptoms in a prospective cohort study. As a first step to providing a framework for other investigations, iterative refinement that further incorporates other clinical features is needed to support actionable definitions of PASC.

  PublisherOA PDFDOI

• Distinct immune-response profile of Richter transformation chronic lymphocytic leukemia (CLL), defined by high expression of PD1, LAG3, TIM3 and IL-10

  Leukemia & lymphoma/Leukemia and lymphoma · 2022 · 3 citations

  Senior authorCorresponding
  • Cancer research
  • Medicine
  • Immunology
  DOI

• Quantifying the effect of hydride microstructure on zirconium alloys embrittlement using image analysis

  Journal of Nuclear Materials · 2021 · 43 citations

  • Materials science
  • Composite material
  • Metallurgy
  DOI

• Subterahertz collective dynamics of polar vortices.

  Nature · 2021 · 136 citations

  • Physics
  • Condensed matter physics
  • Optics

  The collective dynamics of topological structures1-6 are of interest from both fundamental and applied perspectives. For example, studies of dynamical properties of magnetic vortices and skyrmions3,4 have not only deepened our understanding of many-body physics but also offered potential applications in data processing and storage7. Topological structures constructed from electrical polarization, rather than electron spin, have recently been realized in ferroelectric superlattices5,6, and these are promising for ultrafast electric-field control of topological orders. However, little is known about the dynamics underlying the functionality of such complex extended nanostructures. Here, using terahertz-field excitation and femtosecond X-ray diffraction measurements, we observe ultrafast collective polarization dynamics that are unique to polar vortices, with orders-of-magnitude higher frequencies and smaller lateral size than those of experimentally realized magnetic vortices3. A previously unseen tunable mode, hereafter referred to as a vortexon, emerges in the form of transient arrays of nanoscale circular patterns of atomic displacements, which reverse their vorticity on picosecond timescales. Its frequency is considerably reduced (softened) at a critical strain, indicating a condensation (freezing) of structural dynamics. We use first-principles-based atomistic calculations and phase-field modelling to reveal the microscopic atomic arrangements and corroborate the frequencies of the vortex modes. The discovery of subterahertz collective dynamics in polar vortices opens opportunities for electric-field-driven data processing in topological structures with ultrahigh speed and density.

  DOI

• DFTTK: Density Functional Theory ToolKit for high-throughput lattice dynamics calculations

  Calphad · 2021 · 30 citations

  • Computer Science
  • Computer Science
  • Computational science
  DOI

• Ultrahigh energy storage in superparaelectric relaxor ferroelectrics

  Science · 2021 · 746 citations

  • Materials science
  • Condensed matter physics
  • Optoelectronics

  Electrostatic energy storage technology based on dielectrics is fundamental to advanced electronics and high-power electrical systems. Recently, relaxor ferroelectrics characterized by nanodomains have shown great promise as dielectrics with high energy density and high efficiency. We demonstrate substantial enhancements of energy storage properties in relaxor ferroelectric films with a superparaelectric design. The nanodomains are scaled down to polar clusters of several unit cells so that polarization switching hysteresis is nearly eliminated while relatively high polarization is maintained. We achieve an ultrahigh energy density of 152 joules per cubic centimeter with markedly improved efficiency (>90% at an electric field of 3.5 megavolts per centimeter) in superparaelectric samarium-doped bismuth ferrite–barium titanate films. This superparaelectric strategy is generally applicable to optimize dielectric and other related functionalities of relaxor ferroelectrics.

  DOI

• 3D printed castle style Fabry-Perot microcavity on optical fiber tip as a highly sensitive humidity sensor

  Sensors and Actuators B Chemical · 2020 · 103 citations

  • Materials science
  • Optoelectronics
  • Optics
  DOI

• Comprehensive molecular genetic studies of Epstein-Barr virus-negative aggressive Natural killer-cell leukemia/lymphoma

  Human Pathology · 2020 · 5 citations

  • Biology
  • Cancer research
  • Immunology
  DOI

Frequent coauthors

• Hamza Tariq

  Northwestern Memorial Hospital

  16 shared

• Madina Sukhanova

  Northwestern Memorial Hospital

  14 shared

• Juehua Gao

  Northwestern Memorial Hospital

  14 shared

• Lucy Fu

  Northwestern University

  13 shared

• Kristy Wolniak

  Northwestern Memorial Hospital

  13 shared

• Taylor Zak

  Northwestern University

  8 shared

• Yihua Chen

  Kunming Medical University

  6 shared

• Yi‐Hua Chen

  Northwestern University

  5 shared

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