Qi Cao
· Professor, UrologyNorthwestern University · Urology
Active 1990–2025
Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.
Research topics
- Internal medicine
- Medicine
- Cell biology
- Chemistry
- Audiology
- Pediatrics
- Biology
- Pharmacology
- Genetics
Selected publications
Nature Cell Biology · 2021 · 105 citations
Senior authorCorresponding2′-O-methylation at internal sites on mRNA promotes mRNA stability
Molecular Cell · 2024-06-01 · 61 citations
articleOpen accessAntihistamine Drug Ebastine Inhibits Cancer Growth by Targeting Polycomb Group Protein EZH2
Molecular Cancer Therapeutics · 2020 · 25 citations
Senior authorCorresponding-knockdown C4-2 cells, which was distinctively different from cells treated with GSK126, an EZH2 enzyme inhibitor. In addition, ebastine treatment effectively reduced tumor growth and progression, and enhanced progression-free survival in triple-negative breast cancer and drug-resistant castration-resistant prostate cancer patient-derived xenograft mice. Our data demonstrated that ebastine is a novel, safe, and potent anticancer agent for patients with advanced cancer by targeting the oncoprotei…
EZH2 directly methylates PARP1 and regulates its activity in cancer
Science Advances · 2024-11-27 · 14 citations
articleOpen accessSenior authorCorrespondingDNA repair dysregulation is a key driver of cancer development. Understanding the molecular mechanisms underlying DNA repair dysregulation in cancer cells is crucial for cancer development and therapies. Here, we report that enhancer of zeste homolog 2 (EZH2) directly methylates poly(adenosine diphosphate-ribose) polymerase-1 (PARP-1), an essential enzyme involved in DNA repair, and regulates its activity. Functionally, EZH2-catalyzed methylation represses PARP1 catalytic activity, down-regulate…
The detection, function, and therapeutic potential of RNA 2'-O-methylation
The Innovation Life · 2024-12-25 · 7 citations
articleOpen accessRNA modifications play crucial roles in shaping RNA structure, function, and metabolism. Their dysregulation has been associated with many diseases, including cancer, developmental disorders, cardiovascular diseases, as well as neurological and immune-related conditions. A particular type of RNA modification, 2'-O-methylation (Nm) stands out due to its widespread occurrence on all four types of nucleotides (A, U, G, C) and in most RNA categories, e.g., mRNA, rRNA, tRNA, miRNA, snRNA, snoRNA, and…
Recent grants
A non-canonical role for EZH2 in rRNA methtlation
NIH · $2.1M · 2021–2026
The inhibitory network between EZH2 and PARP1 in triple-negative breast cancer
NIH · $1.8M · 2017–2023
Frequent coauthors
- 169 shared
Mark A. Rubin
University of Bern
- 163 shared
Sooryanarayana Varambally
University of Alabama at Birmingham
- 157 shared
Arul M. Chinnaiyan
- 157 shared
Matthew K. Iyer
University of Michigan–Ann Arbor
- 155 shared
Xuhong Cao
University of Michigan–Ann Arbor
- 141 shared
John R. Prensner
University of Michigan–Ann Arbor
- 118 shared
Wei Chen
Jiangnan University
- 118 shared
Rohit Malik
Bristol-Myers Squibb (United States)
Labs
Meet the Cao Lab team members. We welcome requests for information about our work and collaboration opportunities.
Education
- 2008
Ph.D., Pathology
University of Michigan
- 2001
MS, Cell Biology
Peking University
- 1998
BS, Cell Biology & Genetics
Peking University
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