Philip Andrew Fisher

About

Dr. Philip Fisher is the Diana Chen Professor of Early Childhood Learning in the Graduate School of Education at Stanford University and serves as the Director of the Stanford Center on Early Childhood. His research focuses on developing and evaluating scalable early childhood interventions in communities, translating scientific knowledge regarding healthy development under conditions of adversity for use in social policy and programs. He is particularly interested in the effects of early stressful experiences on children's development and in prevention and treatment programs aimed at improving children's functioning in areas such as relationships with caregivers and peers, social-emotional development, and academic achievement. Dr. Fisher is the lead investigator of the ongoing RAPID-EC project, a national survey on the well-being of households with young children during the COVID-19 pandemic. He has developed several evidence-based interventions supporting healthy child development in the context of social and economic adversity, including Treatment Foster Care Oregon for Preschoolers (TFCO-P), Kids in Transition to School (KITS), and the Filming Interactions to Nurture Development (FIND) video coaching program for supporting parenting and early childhood care professionals. He has published over 250 scientific papers in peer-reviewed journals and has received notable awards such as the 2012 Society for Prevention Research Translational Science Award and being named a…

Research topics

• Medicine
• Internal medicine
• Biology
• Genetics
• Cancer research
• Radiology
• Pathology
• Computer Science
• Artificial Intelligence
• Machine Learning

Selected publications

• GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

  Nature · 2022 · 763 citations

  . Toxicity was largely related to the location of the tumour and was reversible with intensive supportive care. On-target, off-tumour toxicity was not observed. Three of four patients exhibited clinical and radiographic improvement. Pro-inflammatory cytokine levels were increased in the plasma and cerebrospinal fluid. Transcriptomic analyses of 65,598 single cells from CAR T cell products and cerebrospinal fluid elucidate heterogeneity in response between participants and administration routes.…

  DOI

• Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas

  Nature · 2024-11-13 · 160 citations

  articleOpen access

  Abstract H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the disialoganglioside GD2 (ref. 1 ). Chimeric antigen receptor-modified T cells targeting GD2 (GD2-CART) eradicated DMGs in preclinical models 1 . Arm A of Phase I trial no. NCT04196413 (ref. 2 ) administered one intravenous (IV) dose of autologous GD2-CART to patients with H3K27M-mutant pontine (DIPG) or spinal DMG (sDMG) at two dose levels (DL1, 1 × 10 6 kg − 1 ; DL2, 3 × 10 6 kg −1 ) following lymphodepleting chemot…

  PublisherDOI

• MR imaging features of diffuse intrinsic pontine glioma and relationship to overall survival: report from the International DIPG Registry

  Neuro-Oncology · 2020 · 82 citations

  BACKGROUND: This study describes imaging features of diffuse intrinsic pontine glioma (DIPG) and correlates with overall survival (OS) and histone mutation status in the International DIPG Registry (IDIPGR). METHODS: Four hundred cases submitted to the IDIPGR with a local diagnosis of DIPG and baseline MRI were evaluated by consensus review of 2 neuroradiologists; 43 cases were excluded (inadequate imaging or alternative diagnoses). Agreement between reviewers, association with histone status, a…

  DOI

• Deep Learning for Pediatric Posterior Fossa Tumor Detection and Classification: A Multi-Institutional Study

  American Journal of Neuroradiology · 2020 · 75 citations

  BACKGROUND AND PURPOSE: Posterior fossa tumors are the most common pediatric brain tumors. MR imaging is key to tumor detection, diagnosis, and therapy guidance. We sought to develop an MR imaging-based deep learning model for posterior fossa tumor detection and tumor pathology classification. MATERIALS AND METHODS: = 88). There were 199 controls. Tumor histology served as ground truth except for diffuse midline glioma of the pons, which was primarily diagnosed by MR imaging. A modified ResNeXt-…

  DOI

• MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study

  Radiology · 2022 · 73 citations

  See also the editorial by Chaudhary and Bapuraj in this issue.

  PublisherOA PDFDOI

Recent grants

• NIH Grant RC2CA148491

  NIH · $1.5M · 2013

• NIH Grant R01CA098712

  NIH · $1.8M · 2008

• NIH Grant K12NS049648

  NIH · $1.4M · 2011

Frequent coauthors

• Stewart Goldman

  Lurie Children's Hospital

  380 shared

• Maryam Fouladi

  The Ohio State University

  372 shared

• Ian F. Pollack

  University of Pittsburgh

  369 shared

• Roger J. Packer

  Children's National

  361 shared

• Girish Dhall

  University of Alabama at Birmingham

  355 shared

• Ira J. Dunkel

  Memorial Sloan Kettering Cancer Center

  336 shared

• Shengjie Wu

  Central South University

  335 shared

• Rishi Lulla

  Hasbro Children's Hospital

  329 shared

Education

• MD, Medicine

  UCSF Medical Center

• BA, Human Biology

  Stanford University

• MHS, School of Public Health and Hygiene

  Johns Hopkins University

Awards & honors

• 2012 Society for Prevention Research Translational Science A…
• 2019 Fellow of the American Psychological Society

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