Peter L. Abt
· ProfessorVerifiedUniversity of Pennsylvania · Rehabilitation Medicine
Active 1990–2026
About
Peter L. Abt, M.D., is a Professor of Surgery at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia. He serves as an Attending Surgeon at the Hospital of the University of Pennsylvania in Philadelphia, PA, and is the Surgical Director of Liver Transplant at the same institution. Dr. Abt is part of the Department of Surgery, Division of Transplantation, and his contact information includes an office at 3400 Spruce Street, 2 Ravdin Courtyard, Philadelphia, PA 19104, with phone number 215-662-2094 and email peter.l.abt@uphs.upenn.edu. His educational background includes a B.A. in History and Biology from Brandeis University (1990) and an M.D. from Dartmouth Medical School (1994). His professional focus is on surgical procedures related to transplantation, particularly liver transplantation, and he holds a significant role in the surgical management and academic leadership within the University of Pennsylvania's medical community.
Research topics
- Medicine
- Surgery
- Internal medicine
- Intensive care medicine
- Emergency medicine
- Cardiology
- Nursing
- Virology
- Psychiatry
- Family medicine
- Psychology
Selected publications
Standardizing Data Collection in Normothermic Regional Perfusion in the United States
Annals of Surgery · 2026-04-29
articleNature Medicine · 2026-02-09 · 6 citations
articleCardioVascular and Interventional Radiology · 2026-01-23
articleOpen accessPURPOSE: Approximately 1-7% of patients develop persistent lymphatic ascites after liver transplantation. This study describes the diagnosis and treatment of lymphatic ascites in patients post liver transplantation, refractory to conservative therapy. MATERIALS AND METHODS: A review of the prospectively collected database was conducted to identify patients who received interventions for persistent lymphatic ascites following liver transplantation. Patient demographics, baseline characteristics, imaging findings, procedural details, and follow-up information were gathered. RESULTS: Four adult patients after orthotopic liver transplantation with chylous ascites (CA) and 4 pediatric patients after split liver transplantation with hepatic lymphorrhea (HL) were included in this study. CA patients were characterized by elevated triglycerides (1010 mg/dL, 442-1769), and HL patients were characterized by low serum albumin ascites gradient (SAAG < 1.1) and low triglycerides. In 3/4 patients with CA, dynamic contrast MR lymphangiography and intranodal lymphangiography demonstrated obstruction of the central lymphatic system. The mesenteric lymphatics were then embolized with either n-BCA glue or lipiodol. One-fourth patients had stenosis of the portal vein anastomosis, which was balloon dilated using a transjugular approach. All 4 patients reached resolution of ascites at a median of 27 days. In 3/4 patients presenting with HL, liver lymphangiography demonstrated extravasation of the contrast. That was embolized with either glue or lipiodol. One-fourth patient demonstrated no extravasation but significant lymphangiectasia. In all patients, there was a resolution of ascites at a median of 14 days after intervention. CONCLUSION: Three mechanisms of post-transplantation lymphatic ascites were identified: portal venous hypertension due to iatrogenic obstruction; obstruction of central lymphatics resulting in congestion of the mesenteric lymphatic system and mesenteric lymphatic leak; and liver lymphorrhea. Identification of the mechanism of ascites allowed for successful percutaneous treatment in all patients.
Transplantation · 2026-05-11
articleBACKGROUND: Donation after circulatory death (DCD) kidneys are discarded because of long donor warm ischemic times (WIT), despite an unclear association between WIT and outcomes. METHODS: Using Organ Procurement and Transplantation Network data of adult DCD kidney recipients from 2015 to 2022, we examined donor WIT, using total WIT and 6 definitions of functional WIT (agonal, asystolic, and time beyond derangements in blood pressure or oxygen saturation). We fit logistic and Cox regression models for primary nonfunction (PNF) and 1-y death-censored graft failure (DCGF), respectively, treating WIT linearly and with a spline at the 87.5th percentile. RESULTS: Among 13 673 donors and 24 271 recipients, the median total WIT was 26 min and 1474 transplants were performed from donors with >60 min of total WIT. PNF incidence was 2.6%; 1-y DCGF was 3.8 events per 100 patient-years. In both models, asystolic time was associated with increased hazard of 1-y DCGF (adjusted hazard ratio per 5 min with time linear, 1.12; 95% confidence interval [CI], 1.03-1.22; adjusted hazard ratio per 1 min beyond 12 min, 1.07; 95% CI, 1.02-1.13) and increased odds of PNF (adjusted odds ratio per 5 min with time linear, 1.18; 95% CI, 1.07-1.30; adjusted odds ratio per 1 min beyond 12 min, 1.08; 95% CI, 1.02-1.13). Other measures of donor WIT were not associated with DCGF or PNF. Holding other covariates constant, the absolute risk of 1-y DCGF increased by 0.9% when asystolic time increased from 5 to 25 min in the linear model. CONCLUSIONS: Donors with prolonged total and functional WITs, apart from asystolic time, show no association with 1-y DCGF and PNF. We advocate using these kidneys to expand the donor pool.
DCD Liver Transplant Outcomes Over Time
2026-01-01
book-chapterSenior authorTransplantation · 2025-06-23
articleOpen accessBACKGROUND: There is a growing population of hematopoietic cell transplantation (HCT) survivors who later require a solid organ transplant (SOT). However, there are limited data on survival, risk factors (RFs) for SOT graft loss, and death. METHODS: This is a retrospective Center for International Blood and Marrow Transplant Research study that included recipients of HCT followed by SOT between 2001 and 2017. HCT data were merged with data from the Organ Procurement and Transplantation Network. RESULTS: Eighty patients underwent autologous (45%) or allogeneic (55%) HCT followed by single SOT. Common indications for HCT included leukemia/myelodysplastic syndrome (45%) and plasma cell disorders (38.8%). The median time from HCT to SOT was 47.7 mo. There were 49 kidney, 26 thoracic, and 5 liver transplants. Overall survival from SOT was significantly different by organ ( P = 0.01). Three-year overall survival by organ type was 85% among kidney, 70.7% among thoracic, and 30% among liver SOT recipients. Significant RFs for death included lymphoma versus plasma cell disorders and SOT type; thoracic and liver SOT carried a greater risk of death than kidney SOT. There was no significant difference in SOT failure incidence by SOT type; 3-y overall incidence was 27.8%. RFs for SOT graft loss included lymphoma, liver SOT, and positive recipient cytomegalovirus status at SOT. CONCLUSIONS: In this study, liver SOT recipients had inferior outcomes. However, renal and thoracic SOT recipients after HCT have acceptable outcomes compared with those of the general SOT population, and thus, SOT should be considered a viable treatment option in these patients.
American Journal of Transplantation · 2025-01-01 · 1 citations
articleOpen accessAmerican Journal of Transplantation · 2025-08-01
articleOpen access2025-01-21 · 2 citations
article1st authorCorrespondingPlanning efficient motions of robots is often inhibited by the difficulty to spatially imagine and enhance their dexterity and agility in the task space. To accommodate this complexity, meet short changeover times, and support inclusion along with sustainability goals, robot operators with different experiences and facing a robot diversity need responsive and actionable interfaces. These enable the prediction and optimization of hidden (i.e., internal) performance-critical properties of physical robots, such as their velocity manipulability in the task space and thermal loads in the joint space, in real-time on concerned components. We address these fundamental challenges encountered in several high-level robotized applications by developing a virtual spatial augmentation of physical robots that translates their complex, otherwise invisible manipulability and thermal states, into accessible and interactive visual cues easily interpreted and used by even novices to improve the robot dexterity in the null-space and anticipate issues due to overheating joints. An upskilling immersion based upon augmented reality and enriched with overlaid digital twins is leveraged to this end. While following values targeted by our overarching Metarobotics framework, we stress the non-invasive and sustainable characteristic of the approach. Furthermore, our framework transparently embeds in existing robotized industrial settings, systems of systems, and workflows without production standstills. We emphasize on its semantic interoperability, versatility, and openness driven by the OPC UA standard, share results from experiments, and pointed out emerging basic research implications that deserve further attention.
Clinical Transplantation · 2025-11-01
articleOpen accessBACKGROUND: Normothermic regional perfusion (NRP) is rapidly gaining adoption for donation after cardiac death (DCD) organ recovery in the United States. However, little is known about trends in NRP procured grafts for simultaneous pancreas-kidney transplantation (SPK). DESIGN: SPK recipients between January 2021 and June 2025 were identified using the United Network for Organ Sharing (UNOS)/Organ Procurement and Transplantation Network (OPTN) national data. PATIENTS: DCD-SPK donors and recipients were included and grouped by recovery method. MEASUREMENTS: Donor and recipient demographic data were described. Primary outcomes were pancreas and kidney graft survival at 1 year, evaluated with Kaplan-Meier survival curves. Kidney outcomes included delayed graft function and creatinine levels. RESULTS: A total of 137 DCD SPKs were included, with NRP and super-rapid recovery (SRR) performed in 33 (24%) and 104 (76%) of donors, respectively. Donors in the NRP group were older (28 [22-34] vs. 22 [18-29], p < 0.05) and had a longer withdrawal-to-death time (22 [18-24] vs. 18 [15-22], p < 0.05). Recipients in the NRP group were younger (38 [35-46] vs. 48 [39-55], p < 0.05), more frequently transplanted for Type 1 diabetes, and had worse functional status at the time of transplant. NRP was associated with lower rates of delayed kidney graft function (6% vs. 33%, p < 0.05) and a trend toward lower 6-month creatinine (1.1 vs. 1.3 mg/dL, p = 0.054), with similar 1-year values. One-year pancreas and kidney graft survival following NRP were 91% and 100%, respectively. CONCLUSIONS: Since the introduction of NRP, 24% of the DCD-SPK grafts were procured with NRP. Comparable 1-year kidney and pancreas graft survival between SRR and NRP with lower rates of kidney dysfunction following NRP.
Frequent coauthors
- 109 shared
Peter P. Reese
University of Pennsylvania
- 89 shared
Matthew H. Levine
University of Pennsylvania
- 86 shared
David S. Goldberg
Sylvester Comprehensive Cancer Center
- 73 shared
Cristiano Quintini
Cleveland Clinic
- 73 shared
Bijan Eghtesad
Cleveland Clinic
- 72 shared
Iryna Lobach
Novartis (Switzerland)
- 72 shared
Angela Dolganiuc
University of Florida
- 72 shared
Oliver Duncan
Manchester Metropolitan University
Labs
Peter L. Abt LaboratoryPI
Education
- 1990
B.A., History, Biology
Brandeis University
- 1994
M.D.
Dartmouth Medical School
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