Paul Bigliardi

About

Dr. Paul Bigliardi is a Professor and Director of the Dermato-Allergy Division in the Department of Dermatology at the University of Minnesota. His work focuses on building the Dermato-Allergy Division, emphasizing the diagnosis and management of various allergic conditions such as contact dermatitis, food, and drug allergies and intolerances. His research encompasses clinical and translational studies, including novel designs and executions of clinical trials related to skin, allergy, and wound healing, as well as the integration of innovative non-invasive laser devices like Raman spectroscopy and photoacoustics MSOT to study healthy and diseased skin in humans. His scientific interests extend to skin toxicology and transcutaneous absorption, where he combines in-vitro human 3D skin models with in-vivo studies using laser technologies to evaluate skin toxicology, absorption, and metabolism of compounds, utilizing CRISPR technology and 3D printing. Dr. Bigliardi's work in allergology and immunology investigates drug-induced allergies, microbiome interactions, ethnic differences in allergic reactions, and the impact of pollution on skin immune responses. He is also a key opinion leader in peripheral opioid receptor research and neurodermatology, discovering the opioid receptor system in skin and exploring its effects on sensation, nerve regeneration, skin homeostasis, and tumor growth. His research includes the role of the peripheral nervous system and neuropeptides in skin…

Research topics

• Biochemistry
• Immunology
• Dermatology
• Chemistry
• Biology
• Neuroscience
• Medicine
• Genetics
• Organic chemistry
• Cell biology

Selected publications

• Development of novel alternative hair dyes to hazardous para-phenylenediamine

  Journal of Hazardous Materials · 2020 · 39 citations

  DOI

• Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration

  Allergy · 2024-08-04 · 28 citations

  reviewOpen access

  The 4th Davos Declaration was developed during the Global Allergy Forum in Davos which aimed to elevate the care of patients with atopic dermatitis (AD) by uniting experts and stakeholders. The forum addressed the high prevalence of AD, with a strategic focus on advancing research, treatment, and management to meet the evolving challenges in the field. This multidisciplinary forum brought together top leaders from research, clinical practice, policy, and patient advocacy to discuss the critical…

  PublisherOA PDFDOI

• Functionally expressed bitter taste receptor TAS2R14 in human epidermal keratinocytes serves as a chemosensory receptor

  Experimental Dermatology · 2020 · 18 citations

  signals were found to be mediated by wild-type TAS2R14 and heterotrimeric G proteins. We conclude that TAS2R14 serves as a chemosensory receptor in epidermal keratinocytes and hypothesize that it enables the cells to recognize potentially harmful chemical substances.

  DOI

• Synthesis and Assessment of Non-allergenic Aromatic Amine Hair Dyes as Efficient Alternatives to Paraphenylenediamine

  ACS Sustainable Chemistry & Engineering · 2022-01-03 · 12 citations

  article

  Paraphenylenediamine (PPD) is one of the main ingredients used in permanent hair dyes. It is, however, known to cause allergic contact dermatitis and potentially serious systemic toxicity. With the increasing popularity of hair dyeing, there is a growing need to address the lack of suitable nontoxic hair dyes for PPD-allergic individuals. Our study examines the safety and efficacy of novel aromatic amines (N1–N7) as potential substitutes for PPD. These compounds were designed and synthesized (a)…

  PublisherDOI

• Distinct transcriptomic and metabolomic profiles characterize NSAID-induced urticaria/angioedema patients undergoing aspirin desensitization

  Journal of Allergy and Clinical Immunology · 2022-08-12 · 11 citations

  articleOpen accessSenior author

  BACKGROUND: There is limited data on the mechanisms of aspirin desensitization in patients with nonsteroidal anti-inflammatory drug (NSAID)-induced urticaria/angioedema (NIUA). OBJECTIVES: We sought to characterize the transcriptomic and metabolomic profiles of patients with NIUA undergoing aspirin desensitization. METHODS: PBMCs and plasma were separated from the blood of patients with NIUA undergoing aspirin desensitization for coronary artery disease and NSAID-tolerant controls. RNA was isola…

  PublisherOA PDFDOI

Frequent coauthors

• Mei Bigliardi‐Qi

  University of Minnesota

  197 shared

• Yuri Dancik

  Simcyp (United Kingdom)

  88 shared

• Gopu Sriram

  National University of Singapore

  85 shared

• Bhimsen Rout

  Singapore Polytechnic

  63 shared

• Srinivas Ramasamy

  Agency for Science, Technology and Research

  43 shared

• Christine Neumann

  Heidelberg University

  30 shared

• Ying Zou

  Second Affiliated Hospital of Jilin University

  28 shared

• Ruige Wu

  26 shared

Similar researchers at University of Minnesota

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