Patrick John Casey

About

Patrick John Casey is the James B. Duke Distinguished Professor of Pharmacology and Cancer Biology at Duke University. He holds multiple positions including Professor of Pharmacology and Cancer Biology and is a member of the Duke Cancer Institute. His academic and research focus is within the fields of biochemistry, pharmacology, and cancer biology, contributing to the understanding of these areas through his role at Duke University. His work is associated with the Duke Department of Biochemistry, where he is involved in research and teaching activities.

Research topics

• Biology
• Genetics
• Cell biology
• Medicine
• Gastroenterology
• Pathology
• Immunology
• Internal medicine
• Cancer research

Selected publications

• The emerging roles of Gα12/13 proteins on the hallmarks of cancer in solid tumors

  Oncogene · 2021 · 54 citations

  Senior authorCorresponding

  G12 proteins comprise a subfamily of G-alpha subunits of heterotrimeric GTP-binding proteins (G proteins) that link specific cell surface G protein-coupled receptors (GPCRs) to downstream signaling molecules and play important roles in human physiology. The G12 subfamily contains two family members: Gα12 and Gα13 (encoded by the GNA12 and GNA13 genes, respectively) and, as with all G proteins, their activity is regulated by their ability to bind to guanine nucleotides. Increased expression of bo…

  DOI

• Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal

  Oncogene · 2020 · 18 citations

  Cancer stem cells possess the capacity for self-renewal and resistance to chemotherapy. It is therefore crucial to understand the molecular regulators of stemness in the quest to develop effective cancer therapies. TAZ is a transcription activator that promotes stem cell functions in post-development mammalian cells; suppression of TAZ activity reduces or eliminates cancer stemness in select cancers. Isoprenylcysteine carboxylmethyltransferase (ICMT) is the unique enzyme of the last step of post…

  DOI

• GPCR-Gα13 Involvement in Mitochondrial Function, Oxidative Stress, and Prostate Cancer

  International Journal of Molecular Sciences · 2024-06-28 · 13 citations

  reviewOpen accessSenior authorCorresponding

  genes, respectively, are members of the G12 family of Gα proteins that, along with their associated Gβγ subunits, mediate signaling from specific G protein-coupled receptors (GPCRs). Advanced prostate cancers have increased expression of GPCRs such as CXC Motif Chemokine Receptor 4 (CXCR4), lysophosphatidic acid receptor (LPAR), and protease activated receptor 1 (PAR-1). These GPCRs signal through either the G12 family, or through Gα13 exclusively, often in addition to other G proteins. The effe…

  PublisherOA PDFDOI

• RAB4A is a master regulator of cancer cell stemness upstream of NUMB–NOTCH signaling

  Cell Death and Disease · 2024-10-27 · 8 citations

  articleOpen access

  Cancer stem cells (CSCs) are a group of specially programmed tumor cells that possess the characteristics of perpetual cell renewal, increased invasiveness, and often, drug resistance. Hence, eliminating CSCs is a major challenge for cancer treatment. Understanding the cellular programs that maintain CSCs, and identifying the critical regulators for such programs, are major undertakings in both basic and translational cancer research. Recently, we have reported that RAB4A is a major regulator of…

  PublisherOA PDFDOI

• GNA13 suppresses proliferation of ER+ breast cancer cells via ERα dependent upregulation of the MYC oncogene

  Breast Cancer Research · 2024-07-04 · 4 citations

  articleOpen accessSenior authorCorresponding

  GNA13 (Gα13) is one of two alpha subunit members of the G12/13 family of heterotrimeric G-proteins which mediate signaling downstream of GPCRs. It is known to be essential for embryonic development and vasculogenesis and has been increasingly shown to be involved in mediating several steps of cancer progression. Recent studies found that Gα13 can function as an oncogene and contributes to progression and metastasis of multiple tumor types, including ovarian, head and neck and prostate cancers. I…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R01CA100869

  NIH · $1.4M · 2009

• NIH Grant F32GM011982

  NIH · $45k

• NIH Grant R55GM055717

  NIH · $100k · 1999

Frequent coauthors

• Stephen G. Young

  University of California, Los Angeles

  74 shared

• Mei Wang

  56 shared

• Martin O. Bergö

  Karolinska Institutet

  55 shared

• Patrick Kelly

  Novo Nordisk (United States)

  52 shared

• L.S. Beese

  Duke University Hospital

  50 shared

• Thomas E. Meigs

  49 shared

• Carolyn Weinbaum

  Weill Cornell Medicine

  45 shared

• Christopher B. Newgard

  Duke Medical Center

  43 shared

Education

• Ph.D., Biochemistry

  Brandeis University

  1986

Similar researchers at Duke University

• Robert J. Lefkowitzh-328
• Paul Modrichh-148
• David N. Beratanh-82