Patrick Campbell

About

Patrick Campbell is the College Marketing Coordinator for Undergraduate Education at Penn State. He holds a Bachelor of Arts in Communication Arts and Sciences from Penn State and a Master of Science in Communication Studies from Shippensburg University. In his role, he collaborates across disciplines and departments to enhance the college's communication and marketing efforts, focusing on elevating the college's offerings and supporting student success. His work involves conceptualizing strategies, refining messaging, and leveraging various mediums to engage and inform audiences, with a commitment to continuous evaluation and improvement. Beyond his marketing responsibilities, Patrick Campbell has been actively involved in university service, including being elected to the University Staff Advisory Council (USAC) and serving on committees such as the Office of Ethics and Compliance’s Center for Excellence and the University Equity Leadership Council (UELC). He has also supported community organizations like the Centre County Penn State Alumni Association, American Red Cross, State College Young Professionals, Advocate Penn State, and the Levi Lamb Fund. His contributions reflect a dedication to fostering a positive campus culture and promoting service to others.

Research topics

• Biology
• Biophysics
• Microbiology
• Chemistry
• Materials science
• Biochemistry
• Nanotechnology
• Organic chemistry
• Immunology

Selected publications

• Skin-targeted delivery of extracellular vesicle-encapsulated curcumin using dissolvable microneedle arrays

  Acta Biomaterialia · 2022-07-06 · 117 citations

  articleOpen accessCorresponding

  Therapeutic benefits of curcumin for inflammatory diseases have been demonstrated. However, curcumin's potential as a clinical therapeutic has been hindered due to its low solubility and stability in vivo. We hypothesized that a hybrid curcumin carrier that incorporates albumin-binding and extracellular vesicle (EV) encapsulation could effectively address the current challenges of curcumin delivery. We further postulated that using dissolvable microneedle arrays (dMNAs) for local delivery of cur…

  PublisherDOI

• Engineering exosome polymer hybrids by atom transfer radical polymerization

  Proceedings of the National Academy of Sciences · 2020 · 105 citations

  Exosomes are emerging as ideal drug delivery vehicles due to their biological origin and ability to transfer cargo between cells. However, rapid clearance of exogenous exosomes from the circulation as well as aggregation of exosomes and shedding of surface proteins during storage limit their clinical translation. Here, we demonstrate highly controlled and reversible functionalization of exosome surfaces with well-defined polymers that modulate the exosome's physiochemical and pharmacokinetic pro…

  DOI

• Pneumococcal Extracellular Vesicles Modulate Host Immunity

  mBio · 2021-07-13 · 53 citations

  articleOpen access

  Our studies reveal that Streptococcus pneumoniae (pneumococcus) (pEVs) are internalized by macrophages, T cells, and epithelial cells. In vitro , pEVs induce NF-κB activation in a dosage-dependent manner and polarize human macrophages to an alternative (M2) phenotype. In addition, pEV pretreatment conditions macrophages to increase bacteria uptake and such macrophages may act as a reservoir for pneumococcal cells by increasing survival of the phagocytosed bacteria.

  PublisherDOI

• Pneumococcal extracellular vesicles mediate horizontal gene transfer via the transformation machinery

  mSphere · 2024-11-06 · 9 citations

  articleOpen access

  ABSTRACT Bacterial cells secrete extracellular vesicles (EVs), the function of which is a matter of intense investigation. Here, we show that the EVs secreted by the human pathogen Streptococcus pneumoniae (pneumococcus) are associated with bacterial DNA on their surface and can deliver this DNA to the transformation machinery of competent cells. These findings suggest that EVs contribute to gene transfer in Gram-positive bacteria and, in doing so, may promote the spread of drug resistance genes…

  PublisherDOI

• Engineering 3D Skeletal Muscle Tissue with Complex Multipennate Myofiber Architectures

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-01-08 · 3 citations

  preprintOpen access

  Abstract The hierarchical architecture of skeletal muscle spans from microscale sarcomeres to macroscale myofibers and is integral to its contractile functionality. Pathologies such as volumetric muscle loss (VML) compromise this structure and destroy the native extracellular matrix (ECM), exceeding the regenerative capacity of endogenous repair mechanisms. Here, we present a novel method for tissue engineering biomimetic three-dimensional (3D) skeletal muscle with complex architectures by lever…

  PublisherDOI

Recent grants

• NIH Grant R01EB007369

  NIH · $1.3M · 2011

• NIH Grant R56EB004343

  NIH · $500k · 2010

• Engineering Differentiation of Multi-tissue Units

  NIH · $3.4M · 2005–2014

Frequent coauthors

• Lee E. Weiss

  Carnegie Mellon University

  70 shared

• Saigopalakrishna S. Yerneni

  Carnegie Mellon University

  53 shared

• Mark P. Mooney

  Johns Hopkins University

  28 shared

• Steffi Oesterreich

  26 shared

• Adrian V. Lee

  UPMC Hillman Cancer Center

  26 shared

• Nolan Priedigkeit

  Broad Institute

  26 shared

• James Cray

  The Ohio State University

  24 shared

• Joseph E. Losee

  University of Pittsburgh

  24 shared

Similar researchers at Carnegie Mellon University

• Qin Wangh-123
• Kenneth Davish-83
• Vivek Kapurh-73