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Muriel Lambert

Muriel Lambert

· Professor

Rutgers University · Pathology, Immunology and Laboratory Medicine

Active 1955–2025

h-index28
Citations2.4k
Papers20931 last 5y
Funding$6.3M

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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About

Dr. Muriel Lambert received her PhD from Northwestern University in 1970 and completed post-doctoral training at Harvard University, followed by a fellowship in the Department of Dermatology at Yale University School of Medicine. Her research focuses on the role of DNA repair in maintaining genomic stability in genetic diseases with defective DNA repair mechanisms. She has concentrated on disorders such as xeroderma pigmentosum and Fanconi anemia, with particular interest in the underlying mechanisms of Fanconi anemia, a hematological disorder characterized by defective DNA repair, genomic instability, and a predisposition to cancer. Her laboratory has demonstrated that the structural protein non-erythroid alpha-spectrin (aIISp) is present in cell nuclei where it plays a role in DNA repair, telomere maintenance, and chromosomal stability. She has shown that FA cells exhibit a deficiency in aIISp due to increased cleavage by ??-calpain, which contributes to the DNA repair defects, telomere dysfunction, and chromosomal instability observed in these cells. Her work has proposed a model in which aIISp binds to damaged DNA to facilitate repair, and restoring its levels can correct repair defects and genomic instability in FA cells. Dr. Lambert is also involved in teaching, serving as course director for courses such as Cellular Pathology and DNA Repair in Health and Disease.

Research topics

  • Computer Science
  • Sociology
  • Political Science
  • Machine Learning
  • Artificial Intelligence
  • Law
  • Economics
  • Medicine
  • Demography
  • Economic growth

Selected publications

Recent grants

Frequent coauthors

  • W. Clark Lambert

    Rutgers New Jersey Medical School

    81 shared

  • W Clark Lambert

    Rutgers New Jersey Medical School

    66 shared

  • Deepa Sridharan

    45 shared

  • Robert A. Schwartz

    Rutgers New Jersey Medical School

    43 shared

  • W. Clark Lambert

    Rutgers, The State University of New Jersey

    41 shared

  • Claude E. Gagna

    New York Institute of Technology

    30 shared

  • Laura McMahon

    University College Dublin

    28 shared

  • Pan Zhang

    Yangtze University

    27 shared

Education

  • Ph.D.

    Northwestern University

    1970

  • B.A.

    Sweet Briar College

    1966

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