About

Mollie K Lagrew is a faculty member associated with the University of Florida Department of Ophthalmology. The page does not provide specific details about her research focus, background, or key contributions. The information available primarily describes the department's glaucoma service, clinical facilities, and opportunities for collaboration and education within the department.

Research topics

• Medicine
• Ophthalmology
• Internal medicine
• Endocrinology
• Optometry
• Neuroscience
• Surgery
• Bioinformatics
• Biology

Selected publications

• Acute Angle Closure in an 18-Year-Old Due to Plateau Iris

  Cureus · 2024-05-19 · 1 citations

  articleOpen access

  In this case report, we describe a rare case of acute angle closure in an 18-year-old African-American female, attributed to plateau iris. The patient had no significant medical or ocular history and presented with high right-eye pressure, headache, and blurred vision. Ocular examination revealed findings consistent with acute angle closure, with gonioscopy confirming superior iris insertion anterior to Schwalbe's line and a "double hump" sign. Ultrasound biomicroscopy confirmed plateau iris. Treatment involved pharmacological management and bilateral peripheral laser iridoplasty. This case underscores the importance of considering plateau iris syndrome in the differential diagnosis of acute angle closure, even in younger patients, and highlights the role of early diagnosis and appropriate intervention in preventing vision loss.

  PublisherOA PDFDOI

• Bilateral Optic Neuropathy Secondary to Intravenous Carboplatin Therapy

  Journal of Ophthalmic and Vision Research · 2024 · 5 citations

  • Medicine
  • Ophthalmology
  • Surgery

  Purpose: To report a case of carboplatin-induced bilateral optic neuropathy in a patient with metastatic squamous cell carcinoma of the tongue. Case Report: A 65-year-old man with a history of squamous cell carcinoma of the tongue with metastasis to the right axillary lymph node treated with carboplatin and paclitaxel was evaluated for decreased visual acuity in both eyes. Visual acuity was 20/70 in the right eye and no light perception in the left eye. On dilated fundus examination, optic disc edema was present in both eyes with more severity in the left eye, flame shape hemorrhages around the optic nerve head in both eyes and cotton wool spots around the left optic nerve head. Brain and orbital MRI demonstrated enhancement of the bilateral optic nerve sheaths. He was diagnosed with bilateral carboplatin-induced optic neuropathy. Conclusion: Our findings in this case justify monitoring of patients during their course of intravenous carboplatin therapy.

  PublisherOA PDFDOI

• Stevens-Johnson Syndrome (SJS) As the Initial Presentation in a Patient With a New Diagnosis of HIV

  Cureus · 2023-12-10 · 3 citations

  articleOpen access1st authorCorresponding

  A woman in her 40s presented to the emergency department with a diffuse rash consistent with Stevens-Johnson syndrome (SJS). There was no identifiable inciting factor. However, she was newly diagnosed with human immunodeficiency virus (HIV) during that same hospital admission. The leading theory for why she developed SJS given her lack of classic precipitating factors is an immune dysregulation as a result of HIV. Most cases of SJS/toxic epidermal necrolysis (TEN) in patients with HIV are related to highly active antiretroviral therapy and prophylaxis with trimethoprim-sulfamethoxazole. There is a lack of literature regarding SJS as the initial presentation of HIV without known underlying etiology or inciting factors.

  PublisherOA PDFDOI

• The Tibiofibular Line: A Reliable Method of Syndesmosis Assessment in Certain Fibula Morphologies

  Cureus · 2023-03-17

  articleOpen access

  Background The tibiofibular line (TFL) technique was initially proposed to assess syndesmosis reduction. Clinical utility was limited by low observer reliability when applied to all fibulas. This study aimed to refine this technique by describing TFL's applicability to various fibula morphologies. Methods Three observers reviewed 52 ankle CT scans. Observer consistencies for TFL measurement, anterolateral fibula contact length, and fibula morphology were assessed using intraclass correlation (ICC) and Fleiss' Kappa. Results TFL measurement and fibula contact length intra-observer and inter-observer consistencies were excellent (minimum ICC, 0.87). Fibula shape categorization intra-observer consistency was substantial to almost perfect (Fleiss' Kappa, 0.73 to 0.97). Six to 10 mm of fibula contact length corresponded to excellent TFL distance consistency (ICC, 0.80 to 0.98). Conclusion The TFL technique appears best for patients with 6 mm to 10 mm of straight anterolateral fibula. Sixty-one percent (61%) of fibulas featured this morphology, indicating most patients may be amenable to this technique.

  PublisherOA PDFDOI

• The Vitreous Ecosystem in Diabetic Retinopathy: Insight into the Patho-Mechanisms of Disease

  International Journal of Molecular Sciences · 2021 · 32 citations

  • Medicine
  • Ophthalmology
  • Bioinformatics

  Diabetic retinopathy is one of the leading causes of blindness in the world with the incidence of disease ever-increasing worldwide. The vitreous humor represents an extensive and complex interactive arena for cytokines in the diabetic eye. In recent decades, there has been significant progress in understanding this environment and its implications in disease pathophysiology. In this review, we investigate the vitreous ecosystem in diabetic retinopathy at the molecular level. Areas of concentration include: the current level of knowledge of growth factors, cytokine and chemokine mediators, and lipid-derived metabolites in the vitreous. We discuss the molecular patho-mechanisms of diabetic retinopathy based upon current vitreous research.

  PublisherOA PDFDOI

Frequent coauthors

• Anthony Pollizzi

  Duke University

  9 shared

• Christopher W. Reb

  Malcom Randall VA Medical Center

  9 shared

• Joseph G. Monir

  Emory University

  9 shared

• Samuel Korntner

  Amherst College

  4 shared

• Stephanie M. Tillit

  Florida College

  4 shared

• Sohum Sheth

  4 shared

• Ramak Roohipourmoallai

  University of South Florida

  4 shared

• Charles Richard Blake

  Florida College

  4 shared

Education

• MD, College of Medicine

  University of Florida College of Medicine

  2021

Awards & honors

• Alumni Scholarship for Academic Excellence