Mohammad Abbas Yaseen

About

Mohammad Abbas Yaseen is an Assistant Professor in the Bioengineering department at Northeastern University College of Engineering, having joined in January 2020. His research focuses on advanced microscopy for minimally invasive, in vivo characterization of brain function. He leads the Optical Microscopy & Neuro-Imaging Lab (OMNI Lab), which develops and applies high-resolution optical technologies to investigate brain function in rodent models of human disease. His work specifically aims to investigate metabolic and immune features during healthy brain function and their alterations in disease states, with the overarching goal of understanding the etiologies of brain pathologies such as stroke and neurodegenerative diseases. His research endeavors to characterize these conditions at the cellular level within living brains to identify precise biomarkers for diagnosis and therapy.

Research topics

• Neuroscience
• Medicine
• Chemistry
• Materials science
• Biomedical engineering

Selected publications

• Cortical microvascular blood flow velocity mapping by combining dynamic light scattering optical coherence tomography and two-photon microscopy

  Journal of Biomedical Optics · 2023-07-21 · 16 citations

  articleOpen access

  Significance: The accurate large-scale mapping of cerebral microvascular blood flow velocity is crucial for a better understanding of cerebral blood flow (CBF) regulation. Although optical imaging techniques enable both high-resolution microvascular angiography and fast absolute CBF velocity measurements in the mouse cortex, they usually require different imaging techniques with independent system configurations to maximize their performances. Consequently, it is still a challenge to accurately…

  PublisherOA PDFDOI

• Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer’s disease

  Alzheimer s Research & Therapy · 2024-04-10 · 12 citations

  articleOpen accessSenior author

  BACKGROUND: Neuroinflammation, impaired metabolism, and hypoperfusion are fundamental pathological hallmarks of early Alzheimer's disease (AD). Numerous studies have asserted a close association between neuroinflammation and disrupted cerebral energetics. During AD progression and other neurodegenerative disorders, a persistent state of chronic neuroinflammation reportedly exacerbates cytotoxicity and potentiates neuronal death. Here, we assessed the impact of a neuroinflammatory challenge on me…

  PublisherOA PDFDOI

• Spreading Depolarizations Suppress Hematoma Growth in Hyperacute Intracerebral Hemorrhage in Mice

  Stroke · 2023-08-23 · 10 citations

  articleOpen access

  BACKGROUND: Spreading depolarizations (SDs) occur in all types of brain injury and may be associated with detrimental effects in ischemic stroke and subarachnoid hemorrhage. While rapid hematoma growth during intracerebral hemorrhage triggers SDs, their role in intracerebral hemorrhage is unknown. METHODS: We used intrinsic optical signal and laser speckle imaging, combined with electrocorticography, to investigate the effects of SD on hematoma growth during the hyperacute phase (0–4 hours) afte…

  PublisherOA PDFDOI

• Optogenetic Functional Activation Is Detrimental During Acute Ischemic Stroke in Mice

  Stroke · 2024-09-05 · 6 citations

  articleOpen access

  BACKGROUND: Functional activation of the focal ischemic brain has been reported to improve outcomes by augmenting collateral blood flow. However, functional activation also increases metabolic demand and might thereby worsen outcomes. Indeed, preclinical and clinical reports have been conflicting. Here, we tested the effect of functional activation during acute ischemic stroke using distal middle cerebral artery occlusion in anesthetized mice. METHODS: Using transgenic mice expressing channelrho…

  PublisherOA PDFDOI

• Out-of-focus signal rejection for <i>in vivo</i> pO₂ measurements using two-photon phosphorescence lifetime microscopy

  Biomedical Optics Express · 2024-09-11 · 2 citations

  articleOpen access

  Two-photon phosphorescence lifetime microscopy has been a key tool for studying cerebral oxygenation in mice. However, the accuracy of the partial pressure of oxygen (pO 2 ) measurements is affected by out-of-focus signal. In this work, we applied reconfigurable differential aberration imaging to characterize and correct for out-of-focus signal contamination in intravascular pO 2 imaging. Our results show that signal contamination is higher in more oxygenated vessels and that it could be effecti…

  PublisherDOI

Recent grants

• Exploring preclinical amyloid pathology with optical microscopy

  NIH · $432k · 2019–2022

• In Vivo Imaging Alzheimers Disease Pathology with 2-Photon/Lifetime Microscopy

  NIH · $747k · 2015–2018

• NIH Grant K99AG042026

  NIH · $274k · 2015

Frequent coauthors

• Sava Sakadžić

  409 shared

• David A. Boas

  291 shared

• Anna Devor

  Boston University

  227 shared

• Cenk Ayata

  117 shared

• Vivek J. Srinivasan

  106 shared

• Louis Gagnon

  Université Laval

  104 shared

• Buyin Fu

  102 shared

• Carlos A. Gómez

  91 shared

Labs

• Optical Microscopy & Neuro-Imaging LabPI

Similar researchers at Northeastern University

• Herbert Levineh-119
• Raimond Winslowh-72
• Neel Joshih-60