About

Minnie Jan, PT, DPT, CSCS, is an Assistant Professor of Clinical Physical Therapy at the USC Division of Biokinesiology and Physical Therapy. Her educational background includes a Bachelor of Science in Kinesiology and a Bachelor of Arts in Neuroscience from the University of Southern California, a Doctor of Physical Therapy degree from New York University, and a residency in Oncologic Physical Therapy at Memorial Sloan Kettering Cancer Center completed in 2017. Her professional interests focus on physical therapy, with a particular emphasis on oncologic physical therapy. She is involved in clinical education and research within the division, contributing to the advancement of physical therapy practices and education.

Research topics

• Emergency medicine
• Internal medicine
• Medicine
• Physical therapy
• Intensive care medicine
• Nursing

Selected publications

• Early physical rehabilitation dosage in the Intensive Care Unit predicts hospital outcomes after critical COVID-19

  Research Square (Research Square) · 2024

  • Medicine
  • Physical therapy
  • Emergency medicine
  PublisherOA PDFDOI

• Early physical rehabilitation dosage in the intensive care unit associates with hospital outcomes after critical COVID-19

  Critical Care · 2024 · 13 citations

  • Medicine
  • Physical therapy
  • Emergency medicine

  OBJECTIVE: To examine the relationship between physical rehabilitation parameters including an approach to quantifying dosage with hospital outcomes for patients with critical COVID-19. DESIGN: Retrospective practice analysis from March 5, 2020, to April 15, 2021. SETTING: Intensive care units (ICU) at four medical institutions. PATIENTS: n = 3780 adults with ICU admission and diagnosis of COVID-19. INTERVENTIONS: We measured the physical rehabilitation treatment delivered in ICU and patient outcomes: (1) mortality; (2) discharge disposition; and (3) physical function at hospital discharge measured by the Activity Measure-Post Acute Care (AM-PAC) "6-Clicks" (6-24, 24 = greater functional independence). Physical rehabilitation dosage was defined as the average mobility level scores in the first three sessions (a surrogate measure of intensity) multiplied by the rehabilitation frequency (PT + OT frequency in hospital). MEASUREMENTS AND MAIN RESULTS: = 0.68, p < 0.001) demonstrates mechanical ventilation (β = - 0.86, p = 0.001), average mobility score in first three sessions (β = 2.6, p < 0.001) and physical rehabilitation dosage (β = 0.22, p = 0.001) were predictive of AM-PAC scores at discharge when controlling for age, sex, BMI, and ICU LOS. CONCLUSIONS: Greater physical rehabilitation exposure early in the ICU is associated with better physical function at hospital discharge.

  PublisherOA PDFDOI

• Genomic Stability of Aggregatibacter actinomycetemcomitans during Persistent Oral Infection in Human

  PLoS ONE · 2013-06-18 · 9 citations

  articleOpen access

  The genome of periodontal pathogen Aggregatibacter actinomycetemcomitans exhibits substantial variations in gene content among unrelated strains primarily due to the presence or absence of genomic islands. This study examined the genomic stability of A. actinomycetemcomitans during its persistent infection in the same host. Four pairs of A. actinomycetemcomitans strains, each pair isolated from an individual over time (0-10 years), were examined for their gains/losses of genes by whole genome sequencing, comparative genomic hybridization by microarray and PCR analysis. Possible effects due to genomic changes were further assessed by comparative transcriptome analysis using microarrays. The results showed that each pair of strains was clonally identical based on phylogenetic analysis of 150 core genes. A novel 24.1-Kb plasmid found in strain S23A was apparently lost in the sibling strain I23C. A 353-bp inversion affecting two essential genes of the serotype-specific gene cluster was found in the serotype antigen-nonexpressing strain I23C, while the same gene cluster was intact in the serotype-expressing sibling strain S23A. A 2,293-bp deletion affecting a gene encoding oxaloacetate decarboxylase and its neighbor region was found in strain SCC2302 but not in the sibling strain AAS4a. However, no evidence of gains or losses of genomic islands was found in the paired strains. Transcriptome profiles showed little or no difference in the paired strains. In conclusion, the genome of A. actinomycetemcomitans appears to be relatively stable during short-term infection. Several types of genomic changes were observed in the paired strains of A. actinomycetemcomitans recovered from the same subjects, including a mutation in serotype-specific gene cluster that may allow the bacteria to evade host immune response.

  PublisherOA PDFDOI

Frequent coauthors

• Clarisa Martinez

  University of Southern California

  5 shared

• Lori M. Ginoza

  University of Southern California

  5 shared

• Lori A. Michener

  University of Southern California

  5 shared

• Evan Haezebrouck

  University of Michigan–Ann Arbor

  3 shared

• Kirby P. Mayer

  University of Kentucky

  3 shared

• Anna G. Kalema

  University of Kentucky

  3 shared

• Michelle Biehl

  Cleveland Clinic

  3 shared

• Amy M. Pastva

  Duke University

  3 shared

Labs

• Health Equity LabPI