Michael Snyder

About

Michael Snyder is a professor in Genetics at Stanford University and is associated with the Center for Artificial Intelligence in Medicine & Imaging (AIMI). His work focuses on the intersection of genetics and artificial intelligence, contributing to advancements in medical imaging and healthcare. As a faculty member at Stanford, he is involved in research that leverages AI to improve medical diagnostics and treatment, and he plays a key role in the AIMI center's initiatives to integrate cutting-edge technology into healthcare applications.

Research topics

• Biology
• Genetics
• Computational biology
• Medicine
• Computer Science
• Internal medicine
• Evolutionary biology
• Bioinformatics
• Cell biology
• Pathology

Selected publications

• The GTEx Consortium atlas of genetic regulatory effects across human tissues

  Science · 2020 · 5682 citations

  The Genotype-Tissue Expression (GTEx) project was established to characterize genetic effects on the transcriptome across human tissues and to link these regulatory mechanisms to trait and disease associations. Here, we present analyses of the version 8 data, examining 15,201 RNA-sequencing samples from 49 tissues of 838 postmortem donors. We comprehensively characterize genetic associations for gene expression and splicing in cis and trans, showing that regulatory associations are found for alm…

  PublisherOA PDFDOI

• Expanded encyclopaedias of DNA elements in the human and mouse genomes

  Nature · 2020 · 2538 citations

  data. We have developed a registry of 926,535 human and 339,815 mouse candidate cis-regulatory elements, covering 7.9 and 3.4% of their respective genomes, by integrating selected datatypes associated with gene regulation, and constructed a web-based server (SCREEN; http://screen.encodeproject.org) to provide flexible, user-defined access to this resource. Collectively, the ENCODE data and registry provide an expansive resource for the scientific community to build a better understanding of the…

  DOI

• Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

  Nature · 2021 · 2261 citations

  . In the first 53,831 TOPMed samples, we detected more than 400 million single-nucleotide and insertion or deletion variants after alignment with the reference genome. Additional previously undescribed variants were detected through assembly of unmapped reads and customized analysis in highly variable loci. Among the more than 400 million detected variants, 97% have frequencies of less than 1% and 46% are singletons that are present in only one individual (53% among unrelated individuals). These…

  DOI

• Inherited causes of clonal haematopoiesis in 97,691 whole genomes

  Nature · 2020 · 726 citations

  DOI

• The impact of sex on gene expression across human tissues

  Science · 2020 · 703 citations

  Many complex human phenotypes exhibit sex-differentiated characteristics. However, the molecular mechanisms underlying these differences remain largely unknown. We generated a catalog of sex differences in gene expression and in the genetic regulation of gene expression across 44 human tissue sources surveyed by the Genotype-Tissue Expression project (GTEx, v8 release). We demonstrate that sex influences gene expression levels and cellular composition of tissue samples across the human body. A t…

  DOI

Recent grants

• Project 4

  NIH · $5.6M · 2019

• NIH Grant U54DE023789

  NIH · $500k · 2016

• Arabidopsis 2010: Development of an Arabidopsis Proteome Chip

  NSF · $1.8M · 2010–2012

Frequent coauthors

• Mark Gerstein

  286 shared

• Kévin Contrepois

  Stanford University

  155 shared

• Joel Rozowsky

  Lieber Institute for Brain Development

  123 shared

• Joseph C. Wu

  103 shared

• Sherman M. Weissman

  Yale University

  99 shared

• Alexander E. Urban

  Stanford University

  88 shared

• Anshul Kundaje

  Stanford University

  85 shared

• Ghia Euskirchen

  Stanford University

  78 shared

Education

• Ph.D., Genetics

  Stanford University

  1990

• M.D., Medicine

  Stanford University

  1985

• B.S., Biochemistry

  University of California, Berkeley

  1981

Similar researchers at Stanford University

• Ronald Davish-183
• Robert Harringtonh-169
• Robert Westh-146