Michael Markl

About

Michael Markl is the Lester B. and Frances T. Knight Professor of Cardiac Imaging and a Professor of Biomedical Engineering at Northwestern University Feinberg School of Medicine. His research program focuses on developing multi-parametric imaging techniques to better understand the physiological mechanisms of heart disease and stroke, as well as the impact of therapy. His work has been instrumental in establishing '4D Flow MRI' for comprehensive assessment of cardiovascular hemodynamics in heart disease and stroke. Additionally, he has contributed to the development, validation, and application of novel imaging tools for evaluating the structure and function of the heart.

Research topics

• Medicine
• Computer Science
• Artificial Intelligence
• Cardiology
• Internal medicine
• Mathematics
• Radiology
• Physics
• Political Science
• Biomedical engineering

Selected publications

• 4D Flow cardiovascular magnetic resonance consensus statement: 2023 update

  Journal of Cardiovascular Magnetic Resonance · 2023 · 242 citations

  Hemodynamic assessment is an integral part of the diagnosis and management of cardiovascular disease. Four-dimensional cardiovascular magnetic resonance flow imaging (4D Flow CMR) allows comprehensive and accurate assessment of flow in a single acquisition. This consensus paper is an update from the 2015 '4D Flow CMR Consensus Statement'. We elaborate on 4D Flow CMR sequence options and imaging considerations. The document aims to assist centers starting out with 4D Flow CMR of the heart and gre…

  DOI

• International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes

  European Journal of Cardio-Thoracic Surgery · 2021 · 198 citations

  This International Consensus Classification and Nomenclature for the congenital bicuspid aortic valve condition recognizes 3 types of bicuspid valves: 1. The fused type (right-left cusp fusion, right-non-coronary cusp fusion and left-non-coronary cusp fusion phenotypes); 2. The 2-sinus type (latero-lateral and antero-posterior phenotypes); and 3. The partial-fusion (forme fruste) type. The presence of raphe and the symmetry of the fused type phenotypes are critical aspects to describe. The Inter…

  DOI

• Fully automated 3D aortic segmentation of 4D flow MRI for hemodynamic analysis using deep learning

  Magnetic Resonance in Medicine · 2020 · 154 citations

  Senior authorCorresponding

  PURPOSE: To generate fully automated and fast 4D-flow MRI-based 3D segmentations of the aorta using deep learning for reproducible quantification of aortic flow, peak velocity, and dimensions. METHODS: A total of 1018 subjects with aortic 4D-flow MRI (528 with bicuspid aortic valve, 376 with tricuspid aortic valve and aortic dilation, 114 healthy controls) comprised the data set. A convolutional neural network was trained to generate 3D aortic segmentations from 4D-flow data. Manual segmentation…

  DOI

• Association of Regional Wall Shear Stress and Progressive Ascending Aorta Dilation in Bicuspid Aortic Valve

  JACC. Cardiovascular imaging · 2021 · 83 citations

  Senior authorCorresponding
  DOI

• Wall Shear Stress Estimation for 4D Flow MRI Using Navier–Stokes Equation Correction

  Annals of Biomedical Engineering · 2022 · 21 citations

  PublisherOA PDFDOI

Recent grants

• Aortic Plaques and Stroke: Cardiovascular Therapy of Retrograde Embolization Risk

  NIH · $425k · 2016–2019

• Non-invasive Evaluation of Intracranial Atherosclerotic Disease Using Hemodynamic Biomarkers

  NIH · $1.9M · 2020–2025

• Graduate Training Program for Magnetic Resonance Imaging

  NIH · $1.4M · 2019–2029

Frequent coauthors

• James Carr

  Environmental Molecular Sciences Laboratory

  338 shared

• Alex J. Barker

  328 shared

• Jeremy D. Collins

  Mayo Clinic in Arizona

  205 shared

• Susanne Schnell

  166 shared

• Cynthia K. Rigsby

  Lurie Children's Hospital

  136 shared

• Joshua D. Robinson

  Lurie Children's Hospital

  123 shared

• Bradley D. Allen

  Toronto General Hospital

  109 shared

• Patrick M. McCarthy

  106 shared

Labs

• Markl LabPI

Similar researchers at Northwestern University

• Milan Mrksichh-100
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• Igor Efimovh-83